381442 Results for: "single-use assemblies"

Supplier: Prosci

Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1.

Supplier: Biosensis

FUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1/Tip60 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. FUNCTION: Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. Rat and mouse beta-amyloid peptides bind only weakly transient metals and have little reducing activity due to substitutions of transient metal chelating residues. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation (By similarity). FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. SUBUNIT: Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, SHC1, Numb and Dab1. Binding to Dab1 inhibits its serine phosphorylation. Also interacts with GPCR-like protein BPP, FPRL1, APPBP1, IB1, KNS2 (via its TPR domains), APPBP2 (via BaSS) and DDB1. In vitro, it binds MAPT via the MT-binding domains. Associates with microtubules in the presence of ATP and in a kinesin-dependent manner. Interacts, through a C-terminal domain, with GNAO1. Amyloid beta-42 binds CHRNA7 in hippocampal neurons. Beta-amyloid associates with HADH2. TISSUE SPECIFICITY: different isoforms in different tissues: kidney. brain. liver. hippocampus, substania nigra pars compacta and cerebellum. In the cerebellum, all the isoforms are abundantly expressed in Purkinje cells.

Supplier: Ambeed

Sodium-L(+)-glutamate monohydrate 99%

Supplier: MP Biomedicals

L-Glutamic Acid is a non-essential amino acid for human development; referred to as an excitatory amino acid (EAA) due to its role in neurotransmission. Acts as a neurotransmitter at fast synapses; agonist at kainate, NMDA and quisqualate receptors. L-Glutamic acid is one of the two amino acids that contains a carboxylic acid group in its side chains.

Supplier: Novus Biologicals

Durable, nickel-plated magnetic clips are great for hanging notes, calendars, schedules, receipts, or photos on fridges, file cabinets, and other metal surfaces.

Supplier: LGC Standards

Sulphur Standard, Sulfur-Free Yttrium Standard: Y @ 5000 µg/g in Hydrocarbon Oil, 5000 µg/g, VHG, Application: Petroleum Oils & Fuels

Supplier: LGC Standards

Sulphur Standard, Sulfur-Free Zinc Standard: Zn @ 5000 µg/g in Hydrocarbon Oil, 5000 µg/g, VHG, Application: Petroleum Oils & Fuels

Supplier: LGC Standards

Sulphur Standard, Sulfur-Free Lead Standard: Pb @ 5000 µg/g in Hydrocarbon Oil, 5000 µg/g, VHG, Application: Petroleum Oils & Fuels

Supplier: LGC Standards

Sulphur Standard, Sulfur-Free Yttrium Standard: Y @ 1000 µg/g in Hydrocarbon Oil, 1000 µg/g, VHG, Application: Petroleum Oils & Fuels, X-Ray Standards

Supplier: Abcam

Ionotropic Agonists Kit (ab120323) is part of the multiplex kits range. Abcam offers high-quality biological reagents and tools including antibodies, proteins, assays, cell lines and lysates.

Supplier: Abcam

PRC Pathway Modulator Set (ab284177) is part of the multiplex kits range. Abcam offers high-quality biological reagents and tools including antibodies, proteins, assays, cell lines and lysates.

Supplier: Abcam

Protease Inhibitor Cocktail II (ab201116) is part of the multiplex kits range. Abcam offers high-quality biological reagents and tools including antibodies, proteins, assays, cell lines and lysates.

Supplier: AOBChem USA

Basic bulbs provide direct, unfiltered light for utility lighting and bare lamp sockets.

Supplier: Janitorial Supplies

LED light bulbs offer outstanding energy efficiency, long-lasting performance, and just-right brightness, all in one package.

Supplier: AOBChem USA

Premoistened cloths for 10" swiffer sweeper.

Supplier: ARCO

Demonstrates water's maximum density at 4 °C.

Supplier: MEDCHEMEXPRESS LLC MS

Designed to impress, these utensils elevate dining experiences with superior strength and style, while reducing costs and time-consuming cleanup.

Supplier: AOBChem USA

Eco-Products® award-winning new line, vanguard, is a collection of groundbreaking molded fiber containers.

Supplier: AOBChem USA

Design meets versatility with this Keurig® K2550 brewing system that brings versatility and flexibility to any business.

Supplier: MilliporeSigma

Methanol tested for EPA533 and EPA537.1 PFAS Methods LiChrosolv®

Supplier: Berkshire

MicroPolx® 1900 is a knitted polyester/nylon microfiber sealed edge cleanroom wiper.

Supplier: KIDDER MFG. CO. LTD

Students build their own plant center!