4196 Results for: "polymerase"

Supplier: Genetex

Mouse monoclonal to DNA polymerase epsilon

Supplier: Abcam

Phospho RNA polymerase II CTD repeat YSPTSPS antibody pS5 [4H8] ab5408 is a mouse monoclonal antibody that is used in RNA polymerase II CTD repeat YSPTSPS western blotting, immunofluorescence and flow cytometry. Suitable for human, mouse and rat samples. - Antibody clone 4H8 has been tried and trusted by researchers since 2003.

Supplier: Bioss

DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci.

Supplier: Tonbo Biosciences

VerityMAX DNA Polymerase Master Mix contains a proprietary blend of our VerityPfu and Classic++ Hot Start Taq DNA polymerases, engineered and optimized specifically for generating amplicons of up to 35 kb in length with 2.5x higher fidelity than standard Taq polymerase

Supplier: Bioss

DNA polymerase lambda (pol Kappa), also designated DNA polymerase Kappa or Pol Beta2, is a low-fidelity polymerase which plays a role in both spontaneous and DNA damage-induced mutagenesis. Encoded by the POLL gene, pol Kappa is a member of the DNA polymerase type-X family. Pol Kappa extends primer-terminal mispairs opposite nondamaged DNA templates, suggesting that it may assist in extending mismatched base pairs during normal DNA replication. In addition, pol Kappa may play a role in the mutagenic bypass of T-T dimers. Proliferating cell nuclear antigen (PCNA), a protein essential to DNA replication, interacts with pol Kappa and thus influences the ability of pol Kappa to synthesize DNA.

Supplier: Abcam

Rat Recombinant Monoclonal RNA polymerase II RPB1 phospho S5 antibody. BSA and Azide free. Suitable for ICC/IF, ChIP, Dot, WB, I-ELISA and reacts with Mouse, Human, Rat, Synthetic peptide samples. Cited in 2 publications.

Supplier: Bioss

DNA polymerase activity is essential for replication, repair, recombination and mutagenesis. DNA polymerases can often bypass DNA lesions that block DNA replication, thereby allowing the replication of damaged DNA. One such DNA polymerase is the distributive enzyme DNA Pol i, which is encoded by the POLI gene. POLI is located on human chromosome 18q21.2, a region often implicated in the etiology of many human cancers. At thymine templates, DNA Pol i is highly error-prone when replicating undamaged DNA in that it favors the misincorporation of guanine over the correct nucleotide, adenosine. DNA Pol i also promotes the replication of damaged DNA by misincorporating deoxynucleotides opposite DNA lesions. DNA Pol i acts sequentially with DNA Pol Ω, which is essential for damage-induced mutagenesis, to complete the DNA lesion bypass. Therefore, replication involving DNA Pol i is likely to be highly mutagenic.

Supplier: Novus Biologicals

The RNA Polymerase II / POLR2A Antibody from Novus Biologicals is a rabbit polyclonal antibody to RNA Polymerase II / POLR2A. This antibody reacts with human. The RNA Polymerase II / POLR2A Antibody has been validated for the following applications: Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.

Supplier: Bioss

DNA polymerase lambda (pol Kappa), also designated DNA polymerase Kappa or Pol Beta2, is a low-fidelity polymerase which plays a role in both spontaneous and DNA damage-induced mutagenesis. Encoded by the POLL gene, pol Kappa is a member of the DNA polymerase type-X family. Pol Kappa extends primer-terminal mispairs opposite nondamaged DNA templates, suggesting that it may assist in extending mismatched base pairs during normal DNA replication. In addition, pol Kappa may play a role in the mutagenic bypass of T-T dimers. Proliferating cell nuclear antigen (PCNA), a protein essential to DNA replication, interacts with pol Kappa and thus influences the ability of pol Kappa to synthesize DNA.

Supplier: Abcam

Rabbit Recombinant Monoclonal RNA polymerase II RPB1 antibody. Suitable for ChIP, IP, Flow Cyt (Intra), ICC/IF, IHC-P, Dot, WB and reacts with Human, Mouse, Rat, Synthetic peptide - Human samples. Cited in 1 publication.

Supplier: Abcam

Rat Recombinant Monoclonal RNA polymerase II RPB1 phospho T4 antibody. BSA and Azide free. Suitable for Dot, WB, I-ELISA and reacts with Synthetic peptide, Rat, Human samples. Cited in 1 publication.

Supplier: Bioss

DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases (1). In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches (2). These exonucleases include the family of DNA polymerases (3). DNA pol α, β, ∂, and e are involved in DNA replication and repair (4). DNA pol ∂ and DNA pol e are multisubunit enzymes, with DNA pol ∂ consisting of two subunits p125, which interacts with the sliding DNA clamp protein PCNA, and p50 (5). The nuclear-encoded DNA pol © is the only DNA polymerase required for the replication of the mitochondrial DNA (6). DNA pol Ω is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis (7). DNA pol œ is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks (8).

Supplier: Bioss

DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci.

Supplier: Abcam

Rat Recombinant Monoclonal RNA polymerase II RPB1 phospho T4 antibody. Suitable for Dot, WB, I-ELISA and reacts with Human, Rat samples. Cited in 1 publication.

Supplier: Genetex

Rabbit Polyclonal antibody to DNA Polymerase epsilon p59 (polymerase (DNA directed), epsilon 2 (p59 subunit))

Supplier: Abcam

Anti-RNA polymerase II CTD repeat YSPTSPS (phospho S2) antibody is a rabbit polyclonal antibody used for detecting phosphorylated serine 2 (pS2) on the C-terminal domain (CTD) repeat YSPTSPS of RNA polymerase II. Suitable for ICC/IF, western blot and IHC. Reacts with human, mouse, and rat samples. - Cited in over 540 publications - Tried and trusted by researchers since 2004.

Supplier: Bioss

DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci.

Supplier: Bioss

DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci.

Supplier: Bioss

DNA polymerase activity is essential for replication, repair, recombination and mutagenesis. DNA polymerases can often bypass DNA lesions that block DNA replication, thereby allowing the replication of damaged DNA. One such DNA polymerase is the distributive enzyme DNA Pol i, which is encoded by the POLI gene. POLI is located on human chromosome 18q21.2, a region often implicated in the etiology of many human cancers. At thymine templates, DNA Pol i is highly error-prone when replicating undamaged DNA in that it favors the misincorporation of guanine over the correct nucleotide, adenosine. DNA Pol i also promotes the replication of damaged DNA by misincorporating deoxynucleotides opposite DNA lesions. DNA Pol i acts sequentially with DNA Pol Ω, which is essential for damage-induced mutagenesis, to complete the DNA lesion bypass. Therefore, replication involving DNA Pol i is likely to be highly mutagenic.

Supplier: G-Biosciences

Hot Start Taq DNA polymerase 2X master mix contains chemically modified hot start Taq DNA Polymerase, dNTPs and optimized buffer with stabilizers.

Supplier: Bioss

DNA polymerase activity is essential for replication, repair, recombination and mutagenesis. DNA polymerases can often bypass DNA lesions that block DNA replication, thereby allowing the replication of damaged DNA. One such DNA polymerase is the distributive enzyme DNA Pol i, which is encoded by the POLI gene. POLI is located on human chromosome 18q21.2, a region often implicated in the etiology of many human cancers. At thymine templates, DNA Pol i is highly error-prone when replicating undamaged DNA in that it favors the misincorporation of guanine over the correct nucleotide, adenosine. DNA Pol i also promotes the replication of damaged DNA by misincorporating deoxynucleotides opposite DNA lesions. DNA Pol i acts sequentially with DNA Pol Ω, which is essential for damage-induced mutagenesis, to complete the DNA lesion bypass. Therefore, replication involving DNA Pol i is likely to be highly mutagenic.

Supplier: Abcam

Rat Recombinant Monoclonal RNA polymerase II RPB1 phospho S7 antibody. Suitable for IP, ChIP, WB, I-ELISA, ICC/IF and reacts with Human, Mouse, Rat, Synthetic peptide - Human samples.

Supplier: Abcam

Anti-RNA polymerase II CTD repeat YSPTSPS (phospho S5) antibody is a rabbit polyclonal antibody used for detecting phosphorylated serine 5 (pS5) on the C-terminal domain (CTD) repeat YSPTSPS of RNA polymerase II. Validated for ICC/IF, western blotting, ChIP, IP and IHC. Suitable for human, mouse, and rat samples. - Cited in over 440 publications - Tried and trusted by researchers since 2005.

Supplier: Abcam

Rabbit Recombinant Monoclonal RNA polymerase II RPB1 phospho S2 antibody. Suitable for IP, ChIP, Dot, WB, ICC/IF, ChIP-seq, Flow Cyt (Intra), IHC-P and reacts with Human, Mouse, Rat samples. Cited in 5 publications.

Supplier: Abcam

Rabbit recombinant monoclonal RNA polymerase II RPB1 antibody. BSA and azide free. Suitable for WB, Dot, ChIP, IP, Flow Cyt (Intra), ICC/IF, IHC-P and reacts with Rat, Mouse, Human, Synthetic peptide - Human samples.

Supplier: Agilent Technologies

This DNA polymerase is ideal for a variety of techniques requiring high-fidelity DNA synthesis by the polymerase chain reaction (PCR).

Supplier: Abcam

Rabbit recombinant monoclonal RNA polymerase II RPB1 phospho S5 antibody. Suitable for IHC-P, Dot, WB, ICC/IF and reacts with Human, Mouse, Rat, Synthetic peptide samples. Cited in 1 publication.

Supplier: Abcam

Rabbit Recombinant Monoclonal RNA polymerase II RPB1 phospho S5 antibody. BSA and Azide free. Suitable for IHC-P, ICC/IF, Dot, WB and reacts with Human, Mouse, Rat, Synthetic peptide samples.

Supplier: Abcam

Rabbit Recombinant Monoclonal RNA polymerase II RPB1 phospho S2 antibody. Suitable for IP, ChIP, Dot, WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Human, Mouse, Rat, Synthetic peptide samples. Cited in 24 publications.

Supplier: Bioss

DNA polymerase activity is essential for replication, repair, recombination and mutagenesis. DNA polymerases can often bypass DNA lesions that block DNA replication, thereby allowing the replication of damaged DNA. One such DNA polymerase is the distributive enzyme DNA Pol i, which is encoded by the POLI gene. POLI is located on human chromosome 18q21.2, a region often implicated in the etiology of many human cancers. At thymine templates, DNA Pol i is highly error-prone when replicating undamaged DNA in that it favors the misincorporation of guanine over the correct nucleotide, adenosine. DNA Pol i also promotes the replication of damaged DNA by misincorporating deoxynucleotides opposite DNA lesions. DNA Pol i acts sequentially with DNA Pol Ω, which is essential for damage-induced mutagenesis, to complete the DNA lesion bypass. Therefore, replication involving DNA Pol i is likely to be highly mutagenic.