7710 Results for: "ice+bucket"

Supplier: Abcam

Potent, selective, non-ATP competitive MEK1/2 inhibitor (IC₅₀ MEK1 =14 nM). Also inhibits ERK1/2 phosphorylation.

Supplier: Abcam

Competitive melatonin receptor antagonist (IC₅₀ = 1 μM). Shows selectivity towards melatonin 1B (Ki values are 45 and 603 nM for MEL-1B and MEL-1A respectively). Inhibits melatonin-induced pigment aggregation (IC₅₀ = 2.1 μM) and shows neuroprotective effects in vivo.

Supplier: Novus Biologicals

The Gankyrin Antibody [FITC] from Novus Biologicals is a rabbit polyclonal antibody to Gankyrin. This antibody reacts with human. The Gankyrin Antibody [FITC] has been validated for the following applications: Immunocytochemistry / Immunofluorescence, Flow (Intracellular).

Supplier: Abcam

Mitochondrial electron transport chain complex I inhibitor (IC₅₀ values are 1.7 - 2.2 μM). Potent NADH oxidation inhibitor (IC₅₀ = 3.4 nM). Suppresses microtubule assembly. Induces BRL cell apoptosis. Shows antiproliferative effects. Shows central effects. Induces parkinsonian behavior in vivo. .

Supplier: Vileda Professional - FHP

The less time spent on cleanroom cleaning, the less interference with keeping the core business running. The unique CE Duo Mop concept is the perfect answer for the high demands of effective cleaning and disinfection of cleanrooms and controlled environments. It is faster, easier, and twice as efficient as traditional methods. The CE Duo Mops allow users to achieve contact time requirements for common disinfectants, and still reach an excellent cleaning performance, with up to 99.99% bacteria removal. The CleanTech™ and SanTech™ Duo Mops form the most efficient and reliable cleaning concept in the market for contamination control.

Supplier: Abcam

Selective blocker of NaV1.8 channels (IC₅₀ =8 nM for human NaV1.8 ). Shows greater than 100-fold selectivity over human NaV1.2, NaV1.3, NaV1.5, and NaV1.7 (IC₅₀ values =1 μM). Shows no significant activity against TRPV1, P2X₂/₃, CaV2.2 and KCNQ2/3 channels. Antinociceptive.

Supplier: Aladdin Scientific

Bml-260 is a potent inhibitor of the DUSP22 (dual specificity phosphatase 22, JSP-1) (IC|50|=18 μM).

Supplier: Abcam

HDAC inhibitor (IC₅₀ = 100 nM). Shows selectivity for HDAC6. Inhibits growth of various cancer cells. Apoptosis inducer.

Supplier: Sonoco Thermosafe

These nontoxic, reusable gel packs have a blow-molded, durable plastic exterior and are an alternative to water-based ice packs.

Supplier: Abcam

A potent and irreversible inhibitor of human myeloperoxidase (MPO) (IC₅₀ =140 nM). Displays similar potency in mouse and rat enzymes.

Supplier: Bel-Art Products, a Part of SP

Rugged, large capacity 8.5L (9qt.) trays may be used to contain ice, a water bath, glassware, or instruments for autoclaving.

Supplier: MilliporeSigma

E-4031, a potent and selective inhibitor of the rapid type of inactivating inward-rectifying K⁺ current (IK, IR) (IC₅₀ = 10 nM).

Supplier: Abcam

Selective MMP-13 inhibitor (IC₅₀ = 3.2 μM). Displays no activity against MMP-1, MMP-9 or TACE. Active in vivo.

Supplier: Abcam

PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3; IC₅₀ = 137 nM for human recombinant PFKFB3).

Supplier: Biosensis

Microtubules are 25nm diameter protein rods found in most kinds of eukarytic cells. They are polymerized from a dimeric subunit made of one a subunit and one b tubulin subunit. Microtubules are associated with a family of proteins called microtubule associated proteins (MAPs), which includes the protein t (tau) and a group of proteins referred to as MAP1, MAP2, MAP3, MAP4 and MAP5. MAP2 is made up of two ~280kDa apparent molecular weight bands referred to as MAP2a and MAP2b. A third lower molecular weight form, usually called MAP2c, corresponds to a pair of protein bands running at ~70kDa on SDS-PAGE gels. All these MAP2 forms are derived from a single gene by alternate transcription, and all share a C-terminal sequence which includes either three or four microtubule binding peptide sequences, which are very similar to those found in the related microtubule binding protein t (tau). MAP2 isoforms are expressed only in neuronal cells and specifically in the perikarya and dendrites of these cells. Antibodies to MAP2 are therefore excellent markers on neuronal cells, their perikarya and neuronal dendrites.

Supplier: Texwipe

BetaMop™II features 100% knitted polyester head constructed of tubular polyester.

Supplier: MilliporeSigma

Fluorogenic caspase-3 substrate

Supplier: Abcam

Novel ATP-competitive pan-Akt kinase inhibitor (IC₅₀ values are 2, 13 and 9 nM for Akt1, 2 and 3 respectively). Also exhibits some inhibition of AMPK, PKA and PAK and PKC isoforms (IC₅₀ <100 nM). Displays antiproliferative and apoptotic effects in tumor cell lines.

Supplier: Adipogen

Cabozantinib is very potent inhibitor, with an IC(50) of less than 10nM for VEGFR2, MET, Kit and FLT3-ITD.

Supplier: Abcam

Potent non-selective HDAC inhibitor (IC₅₀ values are 10 and 20 nM for HDAC1 and HDAC3, respectively). Induces apoptosis and shows antiproliferative effects against cancer cell lines (IC₅₀ = 3 - 8 μM). Antitumor effects in vivo. No effect on class III HDACs. Orally active.

Supplier: Adipogen

PI-103 is an isoform-selective class I PI3K and mTOR inhibitor. It has activity on p110alpha-delta with IC(50) values of 2nM, 3nM, 3nM, 15nM respectively. It is less potent against mTOR and DNA-PK with IC(50) values of 30nM and 23nM respectively.

Supplier: Abcam

Potent and selective FAK inhibitor (IC₅₀ =4 nM versus recombunant catalytic fragent). Blocks FAK Tyr397phosphorylation in cultured cells (IC₅₀ =30 to 100 nM). Shows 50 - 250-fold selectivity for FAK aginst a panel of 40 recombinant kinases. Inhibits chemotactic and haptotactic cell migration.

Supplier: Sartorius

Vivaspin® 6 centrifugal concentrators have been developed to offer increased volume flexibility and performance. Vivaspin® 6 can process 6 ml in either swing bucket or fixed angle rotors accepting standard 15 ml conical bottom test tubes.

Supplier: Abcam

PD-1/PD-L1 inhibitor 1 blocks the PD-1/PD-L1 interaction with an IC₅₀ of 6 nM in a cell-free HTRF assay.

Supplier: Pope Scientific

Shallow-form Dewars permit cooling operations not practical with standard cylindrical or spherical Dewars

Supplier: Abcam

Selective, cell-permeable p300/CBP histone acetyltranserase inhibitor (IC₅₀ = 5 μM). Antitumor agent. Active in vitro.

Supplier: Abcam

p53-MDM2 binding inhibitor (IC₅₀ = 13 μM). Less potent enantiomer of (-)-Nutlin-3 (Asc-4428 ). Shows antiproliferative effects (IC₅₀ values are 2.2 and 1.3 μM for human skin and murine fibroblasts respectively). Shows antitumor effects in vivo. Orally active.

Supplier: Abcam

Topoisomerase I and II inhibitor (IC₅₀ = 100 μM). Potent DNA gyrase inhibitor. Antibiotic agent. Inhibits topoisomerase II without inducing DNA strands breaks. Shows antiproliferative effects against cancer cell lines (IC₅₀ values are 75-125 μM for NSCLC cells).

Supplier: Rockland Immunochemical

ULK4 control protein-GST fusion

Supplier: Abcam

Topoisomerase II inhibitor (IC₅₀ = 12 μM). Steroisomer of Doxorubicin. Shows antitumor and antiangiogenic activity in vivo. Cell-permeable.