7710 Results for: "ice+bucket"

Supplier: Adipogen

PI-103 is an isoform-selective class I PI3K and mTOR inhibitor. It has activity on p110alpha-delta with IC(50) values of 2nM, 3nM, 3nM, 15nM respectively. It is less potent against mTOR and DNA-PK with IC(50) values of 30nM and 23nM respectively.

Supplier: Adipogen

TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC(50) of 2.4nM.

Supplier: Abcam

Novel, potent, selective cyclin-dependent kinase (CDK) inhibitor displaying selectivity for CDK1, CDK2, CDK5 and CDK9 (IC₅₀ values are 3, 1, 1 and 4 nM respectively). Potent DNA replication inhibitor that blocks thymidine incorporation in A2780 ovarian cancer cells (IC₅₀ = 4 nM).

Supplier: Abcam

Potent, orally active phosphodiesterase 5 (PDE5) inhibitor (IC₅₀ =4 nM). Various pharmacological effects in vivo.

Supplier: Electron Microscopy Sciences

Effectively heat and cool samples in most water and dry baths.

Supplier: Adipogen

BMS-3 is a potent inhibitor of the LIM kinase. It has IC(50)'s of 5nM and 6nM for LIMK1 and LIMK2 respectively.

Supplier: Adipogen

GNE 477 is a potent and efficacious dual PI3K/mTOR inhibitor with an IC(50) value of 4nM and 21nM respectively.

Supplier: Abcam

CDK/cyclin inhibitor (IC₅₀ values are 7.6 (CDK1/cyclin B), 0.1 (CDK2/cyclin E), 19.8 (CDK4/cyclin D1), 0.45 (CDK7/cyclin H) and 0.06 (CDK9/cyclin T) μM). Shows an IC₅₀ of >100 μM for 10 other kinases. Antiproliferative and anticancer activity in vitro.

Supplier: Bioss

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

Supplier: Abcam

p53-MDM2 binding inhibitor (IC₅₀ = 13 μM). Less potent enantiomer of (-)-Nutlin-3 (Asc-4428 ). Shows antiproliferative effects (IC₅₀ values are 2.2 and 1.3 μM for human skin and murine fibroblasts respectively). Shows antitumor effects in vivo. Orally active.

Supplier: 3M Healthcare

3M™ High Flow Series Manifold Expansion Filter Head, Model SH-EXP is an add-on expansion head capable of increasing the system capacity by allowing the addition of High Flow Series water filtration cartridges.

Supplier: Rockland Immunochemical

Vimentin control protein-HIS Epitope

Supplier: Bachem Americas

Ac-DEVD-CHO is a potent inhibitor of the poly(ADP-ribose) polymerase (PARP) cleavage by caspase-3 (IC₅₀ = 0.2 nM). PARP cleavage occurs at the onset of apoptosis. The peptide aldehyde was able to attenuate apoptotic events in vitro (IC₅₀ = 10 to 100 nM).

Supplier: Biosensis

Nestin is a member of the class IV intermediate filament protein family which is expressed in neuronal stem cells. The molecular weight of human Nestin as determined by SDS-PAGE mobility is about 240kDa. However the real molecular weight is considerably less than this, at 177kDa, the disparity being likely due to the highly charged region of the C-terminal segment. Nestin is relatively poorly conserved in protein sequence across species boundaries, so that the mouse and human proteins have an overall identity of only 62%. As a result antibodies to the human protein often fail to recognize the rodent homologue and vice versa. However this antibody stains both rodent and human Nestin. Antibodies to Nestin are widely used to identify neural stem cells.

Supplier: Abcam

Potent chloride channel blocker (IC₅₀ = 80 nM). GPR35 agonist. Able to uncouple mitochondria. Active in vivo.

Supplier: Texwipe

BetaMop™II features 100% knitted polyester head constructed of tubular polyester.

Supplier: Abcam

Negative control for the Src kinase inhibitor PP2 (ab120308). Inhibits EGFR kinase (IC₅₀ = 2.7 μM).

Supplier: MilliporeSigma

Fluorogenic caspase-3 substrate

Supplier: Abcam

Potent mTOR inhibitor (IC₅₀ = 1.6 - 2.4 nM). Immunosupressant and anticancer activity in vivo. Orally active.

Supplier: Abcam

Selective protease-activated receptor 2 (PAR2) antagonist (IC₅₀ = 1.2 mM). Anti-inflamatory agent. Active in vivo and in vitro.

Supplier: MilliporeSigma

A nonsteroidal anti-inflammatory drug (NSAID) acts as a reversible and competitive inhibitor of cyclooxygenase 1 (COX-1) (IC₅₀=4.85 µm).

Supplier: Bel-Art Products, a Part of SP

Hot Hand® Mitts provide superior protection when handling hot or cold objects, including dry ice.

Supplier: Abcam

A potent, selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor (IC₅₀ =9.4 μM). Displays selectivity over PRMT5, PRMT6 and CARM1 (IC₅₀ values are 166, 283 and >400 μM respectively). Inhibits cell proliferation in leukemia cell lines.

Supplier: Adipogen

SCH900776 is a selective Chk1 inhibitor with an IC(50) of 3nM. It shows 50-fold selectivity for Chk1 versus Chk2.

Supplier: Adipogen

Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC(50) values of 0.6µM, 0.1µM and 0.1µM, respectively.

Supplier: Abcam

Selective and irreversible MAO-B inhibitor (IC₅₀ = 6.8 nM). Elicits neuroprotective and neuronal rescue activity. Alleviates oxidative stress.

Supplier: Abcam

Selective TRPA1 agonist (EC₅₀ = 400 nM). Antinociceptive in vivo. Inhibits mitochondrial ATPase (IC₅₀ = 15 μM). Antifungal.

Supplier: Adipogen

CH4987655 (RO4987655) is an orally active and highly selective small-molecule MEK inhibitor with an in vitro IC(50) of 5.2nM.

Supplier: Adipogen

JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with an IC(50) of 40nM. It also inhibits closely related tyrosine kinases such as Ret (IC(50) of 180nM) and Kit (C50 of 500nM). It has no significant activity (1µM) against VEGFR-1 and VEGFR-3.

Supplier: Learning Resources

Combine students’ favorite dinosaur shapes with counting for hours of learning fun. Use them to sort and classify. Made of soft durable rubber, each is 2" tall. Six dinosaur shapes and colors come packaged in a storage bucket.