7710 Results for: "ice+bucket"

Supplier: Cytiva

TempliPhi™ Kits efficiently prepare micrograms of circular DNA from picogram input material. The DNA templates are prepared by rolling circle amplification (RCA) using bacteriophage Phi29 DNA polymerase. TempliPhi™ uses an isothermal method for the exponential amplification of circular DNA. Phi29 DNA polymerase is active at 30 °C, enabling amplification to be performed at this temperature without the need for thermal cycling. The TempliPhi™ protocol requires less than 20 minutes of hands-on time to amplify 96 samples from bacterial colonies.

Supplier: Adipogen

SD169 is an orally available, ATP-competitive, isoenzyme-selective Mitogen-Activated Protein Kinase (MAPK) inhibitor. It is 38 times more potent against p38alpha MAP kinase (IC(50) of 3.2nM) over p38beta MAP kinase (IC(50) of 122nM).

Supplier: Abcam

Selective, reversible DNA-dependent protein kinase and mTOR inhibitor (IC₅₀ values are 0.28 and 5.3 μM respectively). No affinity for PI3K, ATM and ATR (IC₅₀ values are >100 μM). Able to induce apoptosis in vitro. Cell-permeable.

Supplier: HETTICH INSTRUMENTS

The Hettich Lab Technology ROTANTA 460 benchtop centrifuge series processes large sample volumes at high g-forces for high-throughput laboratories.

Supplier: Biosensis

Peripherin is a class-III neuronal intermediate filament protein found in certain classes of neuron, most of which are located in the peripheral nervous system. Peripherin is a ~57kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. The HGNC name for this protein is PRPH. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in rat pheochromacytoma PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin.

Supplier: Sino Biological

Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human DDIT3, and purified by antigen affinity chromatography.

Supplier: Science First

Demonstrate that a charge cannot exist inside a conductor and re-create Faraday’s classic 'Ice pail' experiment with this kit.

Supplier: Abcam

Inhibits Hh signaling downstream of smo and sufu. IC₅₀ = 5 μM for glioma associated oncogene expression in MEFs.

Supplier: Adipogen

GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC(50) of 398nM, p70S6K IC(50) of 1000nM), and a dramatically improved P450 profile (2.2µM at all isozymes tested).

Supplier: Abcam

PRMT1 inhibitor (IC₅₀ =12.75 μM). Achieve your results faster with highly validated, pure and trusted compounds.

Supplier: Aladdin Scientific

Bml-260 is a potent inhibitor of the DUSP22 (dual specificity phosphatase 22, JSP-1) (IC|50|=18 μM).

Supplier: Abcam

Irreversible EGFR inhibitor (IC₅₀ = 38.5 nM). Greater inhibitory activity against EGFR then erbB-2, Src, Cdk4, c-Met, Raf, MEK/ERK (IC₅₀ values are 1255, 282, >20,000, 4100, 3353 and 800 nM respectively). Active in vivo. .

Supplier: Bioss

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.

Supplier: Adipogen

ZSTK474 Inhibits all four PI3K isoforms in an ATP-competitive manner. IC(50) is approximately 37nM.

Supplier: Heathrow Scientific

Ice-free, non-toxic method to extend the working period and preserve integrity for temperature-sensitive reagents.

Supplier: Abcam

Novel ATP-competitive pan-Akt kinase inhibitor (IC₅₀ values are 2, 13 and 9 nM for Akt1, 2 and 3 respectively). Also exhibits some inhibition of AMPK, PKA and PAK and PKC isoforms (IC₅₀ <100 nM). Displays antiproliferative and apoptotic effects in tumor cell lines.

Supplier: Abcam

Potent, selective inhibitor of the reverse mode of the Na⁺/Ca²+ exchanger (IC₅₀ = ~0.32 μM in guinea pig ventricular cells). Also potent blocker of TRPC channels (IC₅₀ values are 0.46, 0.71 and 1.38 μM at TRPC3, TRPC6 and TRPC5, respectively).

Supplier: Selleck Chemicals

MG-132 is a potent cell-permeable inhibitor of proteasome and calpain with an IC₅₀ of 100 nM.

Supplier: Abcam

Potent and selective ATR kinase inhibitor (IC₅₀ = 5 nM in vitro; IC₅₀ = 50 nM in carcinoma cell lines). Selective versus mTOR (8-fold). Displayed selectivity versus a panel of 442 kinases.Inhibits LoVo colorectal adenocarcinoma tumor cell growth.

Supplier: Adipogen

PI-103 is an isoform-selective class I PI3K and mTOR inhibitor. It has activity on p110alpha-delta with IC(50) values of 2nM, 3nM, 3nM, 15nM respectively. It is less potent against mTOR and DNA-PK with IC(50) values of 30nM and 23nM respectively.

Supplier: Abcam

Potent and selective inihbitor of the tyrosine kinases Lck and Src with IC₅₀ values of 2 nM for Lck and 6 nM for Src.

Supplier: Abcam

Antibiotic agent. DNA helicase inhibitor (IC₅₀ values are 4.3 and 2.5 μM for DNA helicase B and MCM4/6/7 helicase respectively). Inhibits DNA replication (IC₅₀ values are 1 - 4 μM). Weak topoisomerase I and II inhibitor. Inhibits DNA and RNA synthesis. Does not inhibit protein synthesis. Induces G2/M cell cycle arrest. Shows antibacterial effects. Inhibits cancer cell line growth (IC₅₀ values are 1.4 - 4 μM).

Supplier: Eppendorf

Eppendorf Rotors for Centrifuge 5420, precision for diverse applications. Choose from various capacities and speeds to tailor your centrifuge setup. Accessorize with adaptors and buckets, ensuring optimal sample processing in molecular biology and beyond.

Supplier: New Pig

This innovative design transfers weight to load bearing channels to maximize capacity.

Supplier: Abcam

Potent and selective BACE-1 inhibitor (IC₅₀ =20.3 nM for recombinant hBACE-1). Human BACE2 is inhibited with an IC₅₀ of 10.2 nM. Does not inhibit other aspartyl proteases such as cathepsin D, pepsin, and renin. A potential agent to treat Alzheimer's Disease. Inhibits production of Aβ in HEK-293 Swe cells (IC₅₀ values are 18.5 and 19.7 nM for Aβ1-40 and Aβ1-42 respectively) and in PDAPP neuronal cells (IC₅₀ ~10 nM). Reduces dose-dependently brain levels of Aβ, C99 and sAPPβ in orally administered mouse model and plasma Aβ in dog model. Ppenetrates the blood-brain barrier.

Supplier: Adipogen

BMS-3 is a potent inhibitor of the LIM kinase. It has IC(50)'s of 5nM and 6nM for LIMK1 and LIMK2 respectively.

Supplier: Abcam

p53-MDM2 binding inhibitor (IC₅₀ = 13 μM). Less potent enantiomer of (-)-Nutlin-3 (Asc-4428 ). Shows antiproliferative effects (IC₅₀ values are 2.2 and 1.3 μM for human skin and murine fibroblasts respectively). Shows antitumor effects in vivo. Orally active.

Supplier: Bachem Americas

Ac-DEVD-CHO is a potent inhibitor of the poly(ADP-ribose) polymerase (PARP) cleavage by caspase-3 (IC₅₀ = 0.2 nM). PARP cleavage occurs at the onset of apoptosis. The peptide aldehyde was able to attenuate apoptotic events in vitro (IC₅₀ = 10 to 100 nM).

Supplier: Abcam

Potent chloride channel blocker (IC₅₀ = 80 nM). GPR35 agonist. Able to uncouple mitochondria. Active in vivo.

Supplier: Genetex

Rabbit polyclonal antibody to MYO1C (N-terminal)