7710 Results for: "ice+bucket"

Supplier: Eppendorf

The refrigerated Eppendorf Centrifuge 5810 R is the perfect day-to-day centrifuge for laboratories with medium-throughput requirements. It has an extremely compact footprint yet still offers the real versatility of being able to take both tube and plate formats.

Supplier: Abcam

Potent, highly specific inhibitor of Cdk4 (IC₅₀ = 11 nM) and Cdk6 (IC₅₀ = 16 nM). Displays selectivity for Cdk4/6 over a panel of 36 additional protein kinases (IC₅₀ values are >10 μM). Induces G₁ cell cycle arrest and senescence in retinoblastoma protein (Rb)-proficient cell lines. Blocks growth of intracranial glioblastoma multiforme xenografts in mice. Blood-brain barrier permeable.

Supplier: Kemtech America

This Micro Dewar style trap features a dry-ice chamber with the choice of either glass or PTFE stopcock.

Supplier: Unimed-Midwest

The satellite mobile dispensing system offers a low-cost, portable means of accurately diluting concentrated cleaning products for use in mop buckets, sinks, auto scrubbers, tanks, and other containers.

Supplier: MilliporeSigma

A highly selective, competitive, and irreversible inhibitor of caspase-1 and caspase-4

Supplier: Beckman Coulter

The Allegra® X-5 Clinical Benchtop centrifuge at 120V, is specifically designed for routine sample processing of serum, plasma, whole blood and other body fluids, rapid sedimentation of protein precipitates and processing of samples for in-vitro cytotoxicity studies.

Supplier: HETTICH INSTRUMENTS

The Hettich Lab Technology ROTANTA 460 floor-standing centrifuge series processes large sample volumes at high g-forces for high-throughput laboratories.

Supplier: Sartorius

The Vivaspin® Turbo 15 can handle up to 15 ml sample volume in swing bucket rotors and 11 ml in fixed angle rotors accepting 50 ml centrifuge tubes.

Supplier: Abcam

Potent, selective, competitive farnesyltransferase inhibitor (IC₅₀ =55 nM). Inhibits geranylgeranyltransferase I and II and protein prenyltransferase (IC₅₀ values are 92, 34 and 17 μM respectively). Blocks Ha-Ras signalling. Active in vivo.

Supplier: Adipogen

PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600E with an IC(50) of 31nM.

Supplier: Abcam

Inhibits Hh signaling downstream of smo and sufu. IC₅₀ = 5 μM for glioma associated oncogene expression in MEFs.

Supplier: Bioss

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

Supplier: Enzo Life Sciences

Potent lipoxin A₄ agonist, equiactive as LXA₄ in inhibition of LTB₄ induced PMNL chemotaxis (IC₅₀ = 5 nM).

Supplier: Biosensis

Neurofilaments contain three intermediate filament proteins: light (68 kDa), medium (160 kDa) and heavy (200 kDa). Neurofilament heavy (NF200 or NF-H) is phosphorylated and it is thought that this results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.

Supplier: Adipogen

ZSTK474 Inhibits all four PI3K isoforms in an ATP-competitive manner. IC(50) is approximately 37nM.

Supplier: HETTICH INSTRUMENTS

Hettich Lab Technology's UNIVERSAL 320 general-purpose benchtop centrifuge series provides laboratories the performance and flexibility they need to perform a variety of applications.

Supplier: Biosensis

Peripherin is a class-III neuronal intermediate filament protein found in certain classes of neuron, most of which are located in the peripheral nervous system.

Supplier: Hardy Diagnostics

Used in recovering sublethally injured Salmonella and Listeria from food products

Supplier: Chemglass

Condensers are for use with either tap water or a chilled circulator.

Supplier: Electron Microscopy Sciences

Beaker Buddy™ racks are round, anodized aluminum rack for use with beakers, water baths and ice baths

Supplier: Abcam

Monoamine oxidase (MAO) inhibitor (IC₅₀ =0.9 μM). Orally active in vivo.

Supplier: Abcam

Selective TrkA receptor inhibitor. Inhibits NGF-dependent TrkA phosphorylation (IC₅₀ =40 μM). Additionally inhibits ErbB2 and the VEGF receptor FLK-1 (IC₅₀ =~1 μM). Active in vitro and in vivo. Shows antitumor activity.

Supplier: Abcam

Antibiotic agent. DNA helicase inhibitor (IC₅₀ values are 4.3 and 2.5 μM for DNA helicase B and MCM4/6/7 helicase respectively). Inhibits DNA replication (IC₅₀ values are 1 - 4 μM). Weak topoisomerase I and II inhibitor. Inhibits DNA and RNA synthesis. Does not inhibit protein synthesis. Induces G2/M cell cycle arrest. Shows antibacterial effects. Inhibits cancer cell line growth (IC₅₀ values are 1.4 - 4 μM).

Supplier: Abcam

Elvitegravir is an inhibitor of HIV integrase. It inhibits HIV integrase from HIV 1 IIIB (IC₅₀ = 0.7 nM), HIV 2 EHO (IC₅₀ = 2.8 nM) and HIV-2 ROD (IC₅₀ = 1.1 nM) in cell free assays. Elvitegravir blocks integration of HIV cDNA via inhibition of DNA strand transfer. Active against a range of HIV sub-types and against mulit-drug resistant clinical isolates. Potent (IC₅₀ range = 0.21 - 1.15 nM) HIV antiviral activity in various cell-based assays.

Supplier: Abcam

Potent, cell-permeable inhibitor of X-linked inhibitor of apoptosis (XIAP) (IC₅₀ = 4.1 μM). Binds to the XIAP BIR3 protein and interacts with residues crucial for Smac and caspsase-9 binding. Inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells (IC₅₀ = 3.7 - 5.7 μM); minimal effects on normal prostate cells (IC₅₀ = 19.3 - 20.1 μM). Antitumor and anti-inflammatory effects in vivo.

Supplier: Abcam

Competitive cytidine deaminase inhibitor (IC₅₀= 152 μM). Modulates antiproliferative effects. Orally active.

Supplier: Abcam

Potent, selective PLD2 inhibitor (IC₅₀ values are 90 and 500 nM for HEK293 and human cells respectively).

Supplier: Abcam

Potent and selective BACE-1 inhibitor (IC₅₀ =20.3 nM for recombinant hBACE-1). Human BACE2 is inhibited with an IC₅₀ of 10.2 nM. Does not inhibit other aspartyl proteases such as cathepsin D, pepsin, and renin. A potential agent to treat Alzheimer's Disease. Inhibits production of Aβ in HEK-293 Swe cells (IC₅₀ values are 18.5 and 19.7 nM for Aβ1-40 and Aβ1-42 respectively) and in PDAPP neuronal cells (IC₅₀ ~10 nM). Reduces dose-dependently brain levels of Aβ, C99 and sAPPβ in orally administered mouse model and plasma Aβ in dog model. Ppenetrates the blood-brain barrier.

Supplier: Abcam

Potent Hsp90 inhibitor (IC₅₀ of 4nM in OSA 8 cells). Causes cytotoxicity in a variety of hematological and solid tumor cell lines by causing degradation of multiple oncogenic Hsp90 client proteins. Ganetespib inhibits MG63 cell lines with IC₅₀ of 43 nM.

Supplier: Bioss

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.