7709 Results for: "ice+bucket"

Supplier: Abcam

Highly potent, selective VEGFR-2 tyrosine kinase inhibitor (IC₅₀ = 0.9 nM). Shows some inhibition to c-Kit, PDGFRα and FGFR-2 signaling (IC₅₀ = 40-170 nM). Shows antiangiogenic and antitumor effects in vivo.

Supplier: Adipogen

PIK-90 is a potent PI3K inhibitor with IC(50) values of 11, 18, and 58nM for p110alpha, gamma and delta isoforms respectively. It has an IC(50) of 350nM for the p110beta isoform. It also has low mTOR activity.

Supplier: Adipogen

AMG-Tie2-1 is a highly potent, non-selective inhibitor of Tie-2 (IC(50) 1nM).

Supplier: Abcam

TRPV1 vanilloid receptor antagonist (IC₅₀ =562 nM). Analgesic in vivo.

Supplier: Adipogen

SB203580 is a specific, ATP competitive, cell-permeable inhibitor of p38 MAPK with IC(50) of 0.3-0.5µM. It is 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC(50) of 3-5µM.

Supplier: Abcam

Competitive cytidine deaminase inhibitor (IC₅₀=152 μM). Modulates antiproliferative effects. Orally active.

Supplier: Adipogen

CX6258 is a potent inhibitor of Pim-1, Pim-2 and Pim-3 with IC(50) values of 5, 25 and 16nM, respectively.

Supplier: Abcam

Potent, selective and cell-permeable inhibitor of phosphatidylinositol-3-kinase (PI3-kinase) (IC₅₀ ~3 nM).

Supplier: Beckman Coulter

The Allegra® X-5 Clinical Benchtop centrifuge at 120V, is specifically designed for routine sample processing of serum, plasma, whole blood and other body fluids, rapid sedimentation of protein precipitates and processing of samples for in-vitro cytotoxicity studies.

Supplier: HETTICH INSTRUMENTS

The Hettich Lab Technology ROTANTA 460 floor-standing centrifuge series processes large sample volumes at high g-forces for high-throughput laboratories.

Supplier: Abcam

Cell-permeable, ATP-competitive p90 ribosomal S6 kinase (RSK) inhibitor (RSK1 IC₅₀ =31 nM; RSK2 IC₅₀ =24 nM; RSK3 IC₅₀ =18 nM; RSK4 IC₅₀ =15 nM). Selective (10 to 100-fold) over MST2, GSK-3 beta, MARK3, CK1 and Aurora B. Inhibits RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in cell models. May have RSK-independent effects on mTORC1-p70S6K and p21WAF1/CIP1 pathways.

Supplier: Janitorial Supplies

Minimize the potential for contamination by dedicating a color-coded system for floor finishing tasks. Kit includes everything needed to get started: finish pads, mop head frame, and bucket.

Supplier: MilliporeSigma

A highly selective, competitive, and irreversible inhibitor of caspase-1 and caspase-4

Supplier: Bachem Americas

DPDMB, bombesin receptor antagonist with IC₅₀ values for cellular secretion and growth approaching the picomolar region.

Supplier: Janitorial Supplies

Enjoy a break from work and have a hot tea or a refreshing glass of iced tea

Supplier: Abcam

Potent Hedgehog (Hh) signaling inhibitor. Inhibits alcohol dehydrogenase 7 (Adh7) (IC₅₀ = 210 nM) and prevents Gli-dependent transcriptional activity (IC₅₀ = 30 nM). Potently inhibits microtubule assembly. Additionally displays antitumor activity.

Supplier: Abcam

An allosteric inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform (IC₅₀ = 420 nM). PF-9366 inhibits cellular S-Adenosyl-L-methionine (SAM) production with an IC₅₀ of 1.2 μM in H520 lung carcinoma cells.

Supplier: Abcam

Soluble guanylyl cyclase (sGC) activator. Induces cGMP synthesis independent of NO. Potent platelet aggregation inhibitor (IC₅₀ = 36 nM). Shows antivasoconstrictive effects (IC₅₀ = 0.30 μM). Induces phagocytosis. Shows vasodilatory effects in vivo. .

Supplier: Heidolph NA, LLC

Hei-VAP Industrial Safety Rotary Evaporators offer the highest safety and integrated vacuum control.

Supplier: Enzo Life Sciences

Potent lipoxin A₄ agonist, equiactive as LXA₄ in inhibition of LTB₄ induced PMNL chemotaxis (IC₅₀ = 5 nM).

Supplier: Hardy Diagnostics

Used in recovering sublethally injured Salmonella and Listeria from food products

Supplier: Abcam

Potent, selective Met inhibitor (IC₅₀ = 20 nM). Anticancer activity in vivo. Cell-permeable.

Supplier: Chemglass

Condensers are for use with either tap water or a chilled circulator.

Supplier: Adipogen

PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600E with an IC(50) of 31nM.

Supplier: Abcam

Potent, selective inhibitor phosphodiesterase PDE-11 inhibitor (IC₅₀ =0.28 μM). IC₅₀s for PDE1-10 are greater than 100 μM. Significantly elevates cAMP levels and cortisol production in H295R human adenocarcinoma cells.

Supplier: Abcam

Cell permeable COX-2 inhibitor (IC₅₀ = 46 μM). Also inhibits CDK7 and CDK9 activity (IC₅₀ values are 12.3 and 0.19 μM for CDK7 and CDK9 respectively). Anti-inflammatory reagent and apoptosis inducer. Active in vivo.

Supplier: Abcam

Potent, highly specific inhibitor of Cdk4 (IC₅₀ = 11 nM) and Cdk6 (IC₅₀ = 16 nM). Displays selectivity for Cdk4/6 over a panel of 36 additional protein kinases (IC₅₀ values are >10 μM). Induces G₁ cell cycle arrest and senescence in retinoblastoma protein (Rb)-proficient cell lines. Blocks growth of intracranial glioblastoma multiforme xenografts in mice. Blood-brain barrier permeable.

Supplier: Abcam

Potent FLT3 receptor tyrosine kinase inhibitor (IC₅₀ =42 nM). Selective over 22 other kinases. Shows antiproliferative effects (IC₅₀ =340 nM for Human acute myelocytic leukemia MV4-11 cells).

Supplier: Micronova

A series of elasticized slipcovers, with urethane foam interiors, that are ideal for fine cleaning and sanitizing all surfaces and equipment in the cleanroom. Available without a foam interior or gamma irradiated for aseptic environments.

Supplier: Bioss

The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome. [provided by RefSeq, Jul 2008].