7709 Results for: "ice+bucket"

Supplier: Hardy Diagnostics

CRITERION™ Azide Blood Agar Base for the isolation of staphylococci and streptococci

Supplier: Bioss

Caspases are a family of intracellular proteases that mediate cell death and are the principal effectors of apoptosis. Caspase 10 (Mch4, ICE-LAP4, FLICE2) plays an important role in apoptosis induced by a variety of inducers such as TNF alpha and Anti-Fas antibody. It is a large prodomain caspase classified together with caspases 2, 8, and 9 as a signaling caspase. Four isoforms of caspase 10 (caspase 10a, 10b, 10c, and 10d) having the same prodomain but different mature large and small subdomain, have been described. Caspase 10 contains two death domains (DED) involved in linking to the death effector domain of the adapter protein FADD and recruiting the complex to TNFR1 and Fas. The inactive procaspase 10 is variably expressed in many tissues and cell lines as a cytosolic protein. The mature form of caspase 10 comprises two subunits, p23/p17 (splice isoforms) and p12. Interestingly, a caspase 9- dependent processing of caspase 10 by caspase 6 in cell-free extracts has recently been suggested. Caspase 10 can cleave and activate caspases 3, 4, 6, 7, 8, and 9. This is followed by cleavage of numerous key proteins, including the nuclear protein PARP.

Supplier: Abcam

Potent and selective CCR5 antagonist. Blocks binding of MIP-1 alpha (IC₅₀ = 3.3 nM), MIP-1 beta (IC₅₀= 7.2 nM) and RANTES (IC₅₀ = 5.2 nM) to CCR5 in radioligand binding competition assays. Potent anti-HIV activity. Blocks HIV-1 gp120 binding to CCR5 (IC₅₀ = 6.4 nM) preventing cell-cell fusion. Induces macrophage repolarization with anti-tumor effects.

Supplier: Eppendorf

Eppendorf rotor for centrifuges 5418 R, precision redefined. Tailor your centrifugation with varied capacities and speeds. Accessorise with adaptors and buckets for versatility in molecular biology and life science applications.

Supplier: Bioss

Caspases are a family of intracellular proteases that mediate cell death and are the principal effectors of apoptosis. Caspase 10 (Mch4, ICE-LAP4, FLICE2) plays an important role in apoptosis induced by a variety of inducers such as TNF alpha and Anti-Fas antibody. It is a large prodomain caspase classified together with caspases 2, 8, and 9 as a signaling caspase. Four isoforms of caspase 10 (caspase 10a, 10b, 10c, and 10d) having the same prodomain but different mature large and small subdomain, have been described. Caspase 10 contains two death domains (DED) involved in linking to the death effector domain of the adapter protein FADD and recruiting the complex to TNFR1 and Fas. The inactive procaspase 10 is variably expressed in many tissues and cell lines as a cytosolic protein. The mature form of caspase 10 comprises two subunits, p23/p17 (splice isoforms) and p12. Interestingly, a caspase 9- dependent processing of caspase 10 by caspase 6 in cell-free extracts has recently been suggested. Caspase 10 can cleave and activate caspases 3, 4, 6, 7, 8, and 9. This is followed by cleavage of numerous key proteins, including the nuclear protein PARP.

Supplier: Bioss

Caspases are a family of intracellular proteases that mediate cell death and are the principal effectors of apoptosis. Caspase 10 (Mch4, ICE-LAP4, FLICE2) plays an important role in apoptosis induced by a variety of inducers such as TNF alpha and Anti-Fas antibody. It is a large prodomain caspase classified together with caspases 2, 8, and 9 as a signaling caspase. Four isoforms of caspase 10 (caspase 10a, 10b, 10c, and 10d) having the same prodomain but different mature large and small subdomain, have been described. Caspase 10 contains two death domains (DED) involved in linking to the death effector domain of the adapter protein FADD and recruiting the complex to TNFR1 and Fas. The inactive procaspase 10 is variably expressed in many tissues and cell lines as a cytosolic protein. The mature form of caspase 10 comprises two subunits, p23/p17 (splice isoforms) and p12. Interestingly, a caspase 9- dependent processing of caspase 10 by caspase 6 in cell-free extracts has recently been suggested. Caspase 10 can cleave and activate caspases 3, 4, 6, 7, 8, and 9. This is followed by cleavage of numerous key proteins, including the nuclear protein PARP.

Supplier: Remco Products

This unique brush has split fiber bristles to absorb liquid so that the user is able to efficiently carry soapy water from bucket to the surface to be cleaned.

Supplier: 3M Healthcare

Water filtration system designed for hot beverage and ice applications.

Supplier: SAF-T-PAK INC MS

Ideal for use with Saf-T-Temp™ products or Dry ice for thermal control.

Supplier: Adipogen

BX912 is a PDK1 (3-Phosphoinositide-dependent Kinase-1) inhibitor, with an IC(50) of 26nM.

Supplier: Abcam

Potent dopamine reuptake inhibitor (IC₅₀ = 40 nM). Inhibits noradrenaline reuptake (IC₅₀ = 800 nM). Stimulates locomotor activity and shows central effects in vivo.

Supplier: Ward's

Setting new standards in this centrifuge class.

Supplier: Ace Glass

This Dewar condenser is for use with dry ice and other solid cooling agents

Supplier: Rockland Immunochemical

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFa, TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues.

Supplier: Adipogen

S6K-18 is a highly selective inhibitor of S6K1, with an IC(50) of 52nM.

Supplier: Abcam

Non-selective ACAT1 and ACAT2 inhibitor (IC₅₀ values are 10 and 10 μM respectively). Terpendole E analog. Potently inhibits cholesteryl ester formation (IC₅₀ =0.46 μM).

Supplier: Electron Microscopy Sciences

The 20 m to 1 L sizes are supplied with tight-fitting screw caps and warning labels for 10% Formalin with extra space for writing

Supplier: Adipogen

A-674563 is a potent, orally available Akt1 inhibitor with an IC(50) of 11nM. It also displays activity against PKA and CDK2 with IC(50) values of 16 and 46nM respectively.

Supplier: Abcam

Potent inhibitor of TRPV1 (IC₅₀ values are 35 and 6 nM for capsaicin and acid-induced activation respectively). Inhibits TRPM8 (IC₅₀ = 0.8 μM). Reduces hyperalgesia in vivo.

Supplier: Abcam

Highly potent and selective HDAC inhibitor. Greater potency for HDAC4 and HDAC5 (IC₅₀ =11.9 and 4.2 nM, respectively) than other HDAC family members (IC₅₀ values =HDAC1 320 nM, HDAC2 881 nM, HDAC6 55.7 nM, and HDAC8 1278 nM. Demonstrates inhibitor activity in human ovarian cell lines (IC₅₀ =0.49 μM) and cisplatin resistant cell lines (IC₅₀ =0.32 μM).

Supplier: Pel-Freeze Biologicals

Fresh frozen pituitaries are obtained from normal healthy bovine cattle.

Supplier: Shamrock Scientific

Ideal for cryogenic procedures that use dry ice, liquid nitrogen, or deep freezing.

Supplier: ECOLAB LIFE SCIENCES

Compatible with Ecolab Klercide™ mop wipe frames and the triple bucket system, Ecolab Klercide™ sterile disposable flat mopheads are available in 100% polyester material.

Supplier: Abcam

A highly selective inhibitor of phosphatidylinositol 3-kinase (IC₅₀ = 1.4 μM). Selective over a range of other kinases including protein kinase C, protein kinase A, MAPK and PI4- kinase (IC₅₀ >50 μM).

Supplier: Selleck Chemicals

Tadalafil is a PDE-5 inhibitor with IC₅₀ of 1.8 nM.

Supplier: Abcam

A highly selective inhibitor of phosphatidylinositol 3-kinase (IC₅₀ = 1.4 μM). Selective over a range of other kinases including protein kinase C, protein kinase A, MAPK and PI4- kinase (IC₅₀ >50 μM).

Supplier: Abcam

Potent α-glucosidase inhibitor (IC₅₀ = 11 nM). Orally active. Antidiabetic.

Supplier: Ace Glass

Dewar type condenser for use with dry ice or other solid cooling agents

Supplier: Abcam

Potent, competitive EAAT2, EAAT4 and EAAT5 inhibitor (IC₅₀ = 129.2 mM).

Supplier: Biosensis

Neurofilaments are composed of three intermediate filament proteins: light (~68 kDa), medium (~160 kDa) and heavy (~200 kDa), which are involved in the maintenance of the neuronal caliber. Neurofilament light (NF68 or NF-L) is the most abundant of the three proteins.