27728 Results for: "affinity chromatography"

Supplier: Prosci

Interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells.

Supplier: Prosci

PPAPDC1B is a multi-pass membrane protein and it belongs to the PA-phosphatase related phosphoesterase family. It may be a metastatic suppressor for hepatocellular carcinoma.

Supplier: Prosci

The ELF2 gene encodes a protein that physically interacts with AML1 and mediates opposing effects on AML1-mediated transcription of the B cell-specific blk gene.

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KCNK13 encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming domains. The product of this gene is an open channel that can be stimulated by arachidonic acid.

Supplier: Prosci

SERPINE1 acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.

Supplier: Prosci

ZFPL1 is expressed strongly in the exocrine pancreas as a 1.4-kb polyadenylated RNA encoding a putative protein of 310 amino acids.

Supplier: Prosci

KLHL1 contains 6 Kelch repeats and 1 BTB (POZ) domain..It is highly expressed in brain. KLHL1 may play a role in organizing the actin cytoskeleton of the brain cells.

Supplier: Prosci

Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN

Supplier: Prosci

Inhibits NF-κ-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-κ-B p50-p65 and p50-c-Rel complexes.

Supplier: Prosci

Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.

Supplier: Prosci

DULLARD is a serine/threonine phosphatase which may be required for proper nuclear membrane morphology. DULLARD was involved in LPIN1 dephosphorylation. It may antagonize BMP signaling.

Supplier: Prosci

KCMF1 belongs to the KCMF1 family. It contains 1 C2H2-type zinc finger and 1 ZZ-type zinc finger. It has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.

Supplier: Prosci

GYS2 transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. Defects in GYS2 are the cause of glycogen storage disease type 0 (GSD0).

Supplier: Prosci

TMCO3 belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. It is a multi-pass membrane protein. TMCO3 is a probable Na (+)/H (+) antiporter.

Supplier: Prosci

ATP10D is a multi-pass membrane protein. It belongs to the cation transport ATPase (P-type) family, type IV subfamily. The exact function of ATP10D remains unknown.

Supplier: Prosci

ENTPD7 is a multi-pass membrane protein.It belongs to the GDA1/CD39 NTPase family. It preferentially hydrolyzes nucleoside 5'-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP.

Supplier: Prosci

GCNT4 is a glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. It does not have core 4 O-glycan or I-branching enzyme activity.

Supplier: Prosci

IGSF9 belongs to the immunoglobulin superfamily, turtle family. It contains 2 fibronectin type-III domains and 5 Ig-like (immunoglobulin-like) domains. It functions in dendrite outgrowth and synapse maturation.

Supplier: Prosci

Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1).

Supplier: Prosci

MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.

Supplier: Prosci

Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway.

Supplier: Prosci

ZNF415 is involved in transcriptional regulation. The transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppress the transcriptional activities of AP-1 and p53.

Supplier: Prosci

Macrophage CSF, also known as CSF1, is produced by monocytes, fibroblasts and endothelial cells. It stimulates the formation of macrophage colonies, enhances antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages, and inhibits bone resorption by osetoclasts. Natural human MCSF is a dimeric glycoprotein of 70-90 kD molecular weight, existing in multiple glycosylation forms. It binds to a 165 kD glycoprotein of the receptor tyrosine kinase subclass III, a family that includes the receptors for platelet derived growth factor (PDGF) and stem cell factor (SCF).

Supplier: Prosci

MESP1 is a transcription factor. MESP1 plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. MESP1 defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways.

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MTA3 plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels.

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Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.

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Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level

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Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral. Spontaneous regression ('cure') occurs in some cases.

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ZNF555 belongs to the krueppel C2H2-type zinc-finger protein family. It contains 15 C2H2-type zinc fingers and 1 KRAB domain. ZNF555 may be involved in transcriptional regulation.

Supplier: Prosci

Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.