81644 Results for: "Staining Sets and Apparatus, Electron Microscopy Sciences"

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ANTIBODY HOXA9 PAB RABBIT 100UL

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Gentest® Supersomes® Human Control P450 Reductase + b5 0.5ml

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Gentest® Universal Cryopreservation Recovery Medium-A (UCRM-A) 50 ml

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Gentest® Human Hepatocytes Cryopreserved Plateable Inducible 5.0x10e6 cells

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Gentest® Rat Liver Microsomes Sprague Dawley Female Pool

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Gentest® TransportoCells™ HEK Human BSEP Vesicles 0.5 ml

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Gentest® Beagle Dog Hepatocytes Cryopreserved Female Pooled Suspension

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Gentest® Universal Cryopreservation Recovery Medium-B (UCRM-B) 50 ml

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Gentest® Human Hepatocytes Cryopreserved Plateable Inducible 2.5x10e6 cells

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Gentest® TransportoCells™ HEK Human MRP3 Vesicles 0.5 ml

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Gentest® S9 Dog Liver Male Pool 1.0 ml

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HEMOSTAT STRGT STUDNT ROCHESTR-PEAN 14CM

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Gentest® Human Hepatocytes Cryopreserved Suspension SLC Transporter-Qualified 5x10e6

Supplier: Biosensis

High-mobility group proteins were named originally since they are abundand relatively low molecular weight proteins which run quickly on SDS-PAGE gels. High-mobility group protein box 1 (HMGB1, Amphoterin) is one of these. The "bx" in the name refers to the so-called high mobility group (HMG) box, a compact domain involved in DNA binding and protein-protein interactions. the HMGB1 molecule has two of these HMG domains. The protein is alslo called amphoterin, this name being derived from the presence of two highly charged regions in the molecule, a relatively neutrally charged N-terminus and a very negatively charged C-terminus. In fact the molecule is very unusually charged throughout, the human sequence consisting of 16.7% Glutamic acid, 9.3% Aspartic acid, 20% lysine and 9.3% Arginine. HMGB1 can bind Toll like receptor 4 (TLR4) and the Receptor for Advanced Glycation End products (RAGE). TLRs are components of the innate immune system, first recognized as a family of receptors which recognize "Pathogen Associated Molecular Pattern molecules (PAMPs). PAMPs are common components of bacteria and when TLRs bind these a strong inflammatory response is activated. More recently it has been recognized that TLRs can also be activated by Damage Associated Molecular Pattern molecules (DAMPs), which are endogenous substances released from damaged and diseased cells which also bind to TLR family receptors and also activate inflammation. HMGB1 is such a DAMP, binding to TLR4, and much evidence suggests that HMGB1 is a strong activator of inflammation. Interestingly, HMGB1 is released by necrotic cells but not by apoptotic cells (1).

Supplier: Prosci

Cytokeratin 17 (CK17) is a member of the Cytokeratin subfamily of intermediate filament proteins (IF's). It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. CK17 is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands such as mammary, sweat and salivary. CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered an epithelial stem cell marker because CK17 Ab marks basal cell differentiation. CK17 can be useful when included in a panel of antibodies against TTF-1, napsin A, CK5&6, p63, and SOX-2 for diagnostic differentiation between lung adenocarcinoma (LADC) and lung squamous cell carcinoma (SCLC), especially for poorly-differentiated lung carcinoma. CK17 is expressed in SCLC much higher than in LADC. In breast carcinomas, approximately 20% of patients show no expression of ER, PR and Her2, which are defined as triple negative tumor. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. The histologic differentiation of ampullary cancer, intestinal vs. pancreatobiliary, is very important for treatment. Usually anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.

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Gentest® TransportoCells™ HEK Human MDR1/P-gp Vesicles 0.5 ml

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Gentest® Mouse Liver S9 CD-1 Male Pool 1.0 ml

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MHX MetMax®, Complete; High Performance Mouse Hepatocytes, 2.5ml, 5 million cells

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Gentest® Supersome® Ultra Human Aldehyde Oxidase (AOX1) 0.5 ml

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Gentest® Human Hepatocyte Cryopreserved 3D Spheroid-Qualified 5.0x10e6 cells

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KIT SELECT-A-BEAD SPA BEAD 5X100MG

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COLUMN HPLC INERTSIL ODS-4 3UM 50X4.6MM

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Gentest® Rat Liver S9 Sprague Dawley Male Pool 1.0 ml

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DHX MetMax®, Complete; High Performance Dog Hepatocytes, 2.5ml, 5 millions cells

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RHX MetMax®, Complete; High Performance Rat Hepatocytes, 2.5ml, 5 million cells

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Gentest® Beagle Dog Hepatocytes Cryopreserved Mixed Gender Pooled Plateable Inducible

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LAMINAR AIR FLOW LF SERIES STS/XT UNITS

Supplier: MilliporeSigma

100kg

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Gentest® PHHX MetMax®, Complete; High Performance Pooled Human Hepatocytes, 2.5ml, 5.0 million cells, Mixed Gender

Supplier: Biosensis

Myelin is a membrane characteristic of the nervous tissue and functions as an insulator to increase the velocity of the stimuli being transmitted between a nerve cell body and its target. Myelin isolated from human and bovine nervous tissue is composed of approximately 80% lipid and 20% protein, and 30% of the protein fraction constitutes myelin basic protein (MBP). MBP is an 'intrinsically unstructured' protein with a high proportion (approximately 75%) of random coil, but postulated to have core elements of beta-sheet and alpha-helix. MBP is a major protein in CNS myelin and is expressed specifically in the nervous system. A detailed immunochemical examination of monoclonal and polyclonal antibody responses to MBP and its peptides has revealed the existence of as many as 27 antigenic determinants, many of them conformational. Topological mapping of the potential antigenic determinants onto a model of MBP secondary structure places these determinants within 11 separate regions of the molecule, including those portions that have been found to be encephalitogenic. The message for myelin basic protein is selectively translocated to the ends of the cell processes. Immunization with myelin-associated antigens including MBP significantly promotes recovery after spinal cord contusion injury in the rat model. FUNCTION: Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). SUBUNIT: Homodimer (By similarity). SUBCELLULAR LOCATION: Myelin membrane; peripheral membrane protein; cytoplasmic side. Cytoplasmic side of myelin. TISSUE SPECIFICITY: Found in both the central and the peripheral nervous system.