81644 Results for: "Staining Sets and Apparatus, Electron Microscopy Sciences"

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VANE MFX MAGNET STIR 0.3ML PK6

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ANTIBODY SRSF6 RABBIT PAB 100UL

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ANTIBODY DCAF11 RABBIT PAB 20UL

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VIAL STORAGE 4DR 1DBC TW 21X70MM CS1000

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Gentest® TransportoCells™ Human OATP1B1*1a 10e7 cells

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Gentest® Supersomes® Human UGT Control 0.5ml

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Gentest® TransportoCells™ Human PEPT1 10e7 cells

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Gentest® Insect Cell Control Supersomes® 0.5ml

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Gentest® Supersomes® Human CYP4F3B+ OR+b5 0.5ml

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Gentest® TransportoCellsTM Human PEPT2 10e7 cells

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HUMAN SERUM ALBUMIN LYOPHILIZ POWDER 50G

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CAP 48-400 PP WHT POLY-VINYL LNR CS72

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Gentest® Rat Liver Cytosol Sprague Dawley Male 1.0 ml

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SCISSOR SPRING VANNAS 4MM CUT EDGE

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STIRBAR COLOR MICRO RED L 13X1.5MM PK10

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ANTIBODY SRSF6 PAB RABBIT 200UL

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Gentest® Human Liver Microsomes 150 Donor UltraPool™

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Gentest® Supersome® Ultra Human Control Cytosol 0.5 ml

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Gentest® Human Liver S9 150 Donor UltraPool™ 1ml

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VIAL TYPE 1 CLEAR 50 ML CASE 288

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Gentest® Human MRP/BCRP Vesicle Assay Kit

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HUMAN SERUM ALBUMIN LYOPH FATTY FREE 10G

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TUBING TYGON 2001 1/16IDX3/16IN OD 50FT

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Gentest® TransportoCells™ HEK Human BCRP Vesicles 0.5ml

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Gentest® Human Liver Cytosol 150 Donor UltraPool™

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VIAL STORAGE 21X70MM 4DR 1DBC TW CS1000

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Gentest® TransportoCells™ HEK Human MRP2 Vesicles 0.5ml

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Gentest® Supersomes® Human Control P450 Reductase + b5 0.5ml

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ANTIBODY DCAF11 PAB RABBIT 100UL

Supplier: Biosensis

High-mobility group proteins were named originally since they are abundand relatively low molecular weight proteins which run quickly on SDS-PAGE gels. High-mobility group protein box 1 (HMGB1, Amphoterin) is one of these. The "bx" in the name refers to the so-called high mobility group (HMG) box, a compact domain involved in DNA binding and protein-protein interactions. the HMGB1 molecule has two of these HMG domains. The protein is alslo called amphoterin, this name being derived from the presence of two highly charged regions in the molecule, a relatively neutrally charged N-terminus and a very negatively charged C-terminus. In fact the molecule is very unusually charged throughout, the human sequence consisting of 16.7% Glutamic acid, 9.3% Aspartic acid, 20% lysine and 9.3% Arginine. HMGB1 can bind Toll like receptor 4 (TLR4) and the Receptor for Advanced Glycation End products (RAGE). TLRs are components of the innate immune system, first recognized as a family of receptors which recognize "Pathogen Associated Molecular Pattern molecules (PAMPs). PAMPs are common components of bacteria and when TLRs bind these a strong inflammatory response is activated. More recently it has been recognized that TLRs can also be activated by Damage Associated Molecular Pattern molecules (DAMPs), which are endogenous substances released from damaged and diseased cells which also bind to TLR family receptors and also activate inflammation. HMGB1 is such a DAMP, binding to TLR4, and much evidence suggests that HMGB1 is a strong activator of inflammation. Interestingly, HMGB1 is released by necrotic cells but not by apoptotic cells (1).