46849 Results for: "Stainers and Equipment, Electron Microscopy Sciences"

Supplier: Adipogen

NMNAT2 catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form nicotinic acid mononucleotide (NaMN) as a substrate but with lower efficiency. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans. Has been shown to correlate with Alzheimer's disease in APPswe/PS1dE9 transgenic mice and delayed wallerian degeneration in cultured superior cervical ganglia (SCGs) from morphological changes, microtubule destruction and neurofilament degradation.

Supplier: Adipogen

Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells and numerous tumors, including colorectal tumors, squamous cell carcinomas, testicular seminoma and brain tumors. Podoplanin is the ligand for C-type lectin-like receptor 2 (CLEC-2). Their association is dependent on sialic acid on O-glycans of podoplanin. Through its association with CLEC-2, podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.

Supplier: Adipogen

The inflammatory actions of IL-1alpha and beta depend on their interaction with its receptor, IL-1R1, and can be negatively controlled by several inhibitors such as IL-1Ra, IL-1R type 2 (IL-1R2), SIGIRR and the soluble form of IL-1 receptor accessory protein (IL-1RAcP). IL-1R2 neutralizes IL-1 either as a surface decoy receptor or in a cleaved and secreted form. IL-1R2 is expressed on B cells, on neutrophils and on in vitro expanded human Tregs.

Supplier: Adipogen

Reactive oxygen species (ROS) are involved in lipid peroxidation inside the living bodies, and membrane lipids are one of the major targets of ROS. During the peroxidation process, a variery of aldehydes are formed. 4-hydroxy-2-nonenal (4-HNE) is an alpha, beta unsaturated aldehyde that can be formed by peroxidation of omega-6 unsaturated fatty acids such as linoleic acid and arachidonic acid. Especially, 4-HNE formed inside living body is reported to originate from phospholipid-bound arachidonic acid. 4-HNE may be one of the most reliable biomarker of lipid peroxidation.

Supplier: Adipogen

Reactive oxygen species (ROS) are involved in lipid peroxidation inside the living bodies, and membrane lipids are one of the major targets of ROS. During the peroxidation process, a variery of aldehydes are formed. 4-hydroxy-2-nonenal (4-HNE) is an alpha, beta unsaturated aldehyde that can be formed by peroxidation of omega-6 unsaturated fatty acids such as linoleic acid and arachidonic acid. Especially, 4-HNE formed inside living body is reported to originate from phospholipid-bound arachidonic acid. 4-HNE may be one of the most reliable biomarker of lipid peroxidation.

Supplier: Adipogen

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Supplier: Adipogen

Human CD28 is an important costimulatory molecule found on all CD4+ T cells and on about half of the CD8+ T cells. T cell activities attributed to CD28 include prevention of anergy, induction of cytokine gene transcription, stabilization of cytokine mRNA and activation of CD8+ cytotoxic T lymphocytes. The ligands for CD28 identified as CD80 (B7-1) and CD86 (B7-2) are immunglobulin superfamily monomeric transmembrane glycoproteins of 60kDa and 80kDa respectively. Anti-CD28 antibodies have been shown to have a strong adjuvant effect when conjugated to an immunogen. Monovalency of the CD28 receptor for its natural ligands is essential to provide costimulation without inducing responses in the absense of TCR engagement.

Supplier: Adipogen

FLIP is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. FLIP lacks enzymatic (caspase) activity. FLIP is highly expressed in skeletal muscle, pancreas, heart, kidney, placenta and peripheral blood leukocytes.

Supplier: AZENTA US, INC

FreezerPro® is a web-based sample management inventory system designed to support organizations of all sizes with simple and quick installation, from lower throughput labs to central biorepositories handling millions of records.

Supplier: MP Biomedicals

Fibronectins are adhesive glycoproteins and are found both as cell surface proteins and in plasma.

Supplier: Adipogen

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-1 (T cell-immunoglobulinmucin; also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. There are two cytoplasmic alternate splice forms of TIM1. One is a long (359 aa) kidney form termed TIM-1b, and one is a short (334 aa) liver form termed TIM-1a. TIM-1, important for asthma and allergy, is preferentially expressed on T-helper 2 (Th2) cells and functions as a potent costimulatory molecule for T cell activation.

Supplier: Adipogen

Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.

Supplier: AZENTA US, INC

The clear weld heat seal is an optically clear polymer film forms a permanent complete seal to polypropylene plates, enabling both low and very high temperature uses, including low temperature storage and high temperature incubations.

Supplier: MEDMIRA

Reveal® G4 Rapid HIV-1/2 Antibody Test uses MedMira Rapid Vertical Flow Technology to deliver instant results in three easy steps.

Supplier: Labconco

Chairs feature a durable, scratch-resistant seat mold, a welded frame with an elevated 25” chair height, and an ergonomically designed padded arm specifically contoured and angled at 10° to support the patient’s arm in a fully extended position for easier venipuncture

Supplier: Ansell Healthcare

BioClean-C™ Non sterile chemotherapy protective apron with sleeves offers comfort and protection.

Supplier: BioFit

MVMT™ stands for Movement, for ergonomic seating. The chairs are developed to address the unique ergonomic needs and working postures of users in technical environments specifically for healthcare, laboratory, cleanroom and standing-desk applications.

Supplier: BioFit

Bridgeport Series chairs boast a number of features and benefits that make them a popular choice for laboratory, healthcare, education, technical, industrial and office workspaces. The ergonomic design enhances user comfort and productivity when sitting for prolonged periods.

Supplier: Texwipe

Revolve™ sustainable wipes are made for the cleanroom industry and are composed of 100% upcycled polyester material with a sealed edge, processed on Texwipe’s fully automated manufacturing system. Revolve™ wipes contribute to sustainability goals, reducing the amount of post-consumer water bottles going into landfills and reducing the level of carbon emissions.

Supplier: bioMerieux

General purpose medium for the cultivation of a wide variety of microorganisms.

Supplier: MICROBIOLOGICS, INC.

All the required QC strains for the lab’s microbial detection/identification system, already combined in one convenient panel.

Supplier: Ansell Healthcare

Advanced mechanical protection economical light duty cut resistant sleeve.

Supplier: Bel-Art Products, a Part of SP

Protects against exposure to bodily fluids and infectious materials.

Supplier: EMI - Emergency Medical International

The Pro Response™ Basic bag is a downsized version of the Pro Response™ 2 bag.

Supplier: Caron Products

Caron's extra large capacity Refrigerated Incubators precisely control temperature conditions.

Supplier: CHEMetrics

Ceric sulfate is the titrant and ferroin is the end point indicator. The method is free from glycol interference in samples that contain up to 75% glycol, making it particularly applicable to systems that contain nitrite corrosion inhibitors. Results are expressed as ppm (mg/L) NaNO2.

Supplier: Scientific Industries

The FSC is an advanced precision torque tester ideal for accurate verification or adjustment of virtually any manual or electric wrench, and screwdriver. Easily adaptable to almost any working environment and processes.

Supplier: Ansell Healthcare

BioClean-D™ disposable sleeve covers provides comfort and protection.

Supplier: AMPLYUS LLC

Get hands-on experience with the principles of qPCR diagnostics.

Supplier: HANNA INSTRUMENTS

Use our simple handheld colorimeter to get higher accuracy water testing results. Forget about the struggle of matching your sample to a color chart, our total chlorine colorimeter eliminates the struggle and provides you a digital total chlorine result directly. Our ammonia colorimeter brings you more precise technology than your typical chemical test kit giving you accurate and consistent results.