47164 Results for: "Stainers and Equipment, Electron Microscopy Sciences"

Supplier: Adipogen

Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also Involved in tumorigenesis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b.

Supplier: Adipogen

The human CD3/T cell receptor (TcR) complex is made up of the CD3 proteins (gamma, delta, 2 epsilon) and teh zeta-chain in association with either alpha/beta or gamma/delta proteins of the TcR. The TcR recognizes antigens in association with MHC molecules after which protein chains of the CD3 complex mediate activation signals triggered by TcR antigen binding. CD3 is expressed on greater than 95% of circulating human peripheral T cells.

Supplier: Adipogen

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.

Supplier: Cayman Chemical Company

For the quantification of 2’3’-cGAMP in cell lysates.

Supplier: Adipogen

CTRP5 (C1qTNF-related protein 5; C1QTNF5) belongs to a highly conserved family of adiponectin paralogs. CTRP5 mediates activation of AMP-activated protein kinase (AMPK) in muscle and liver cells, thereby regulating glucose and lipid metabolism. Serum levels of CTRP5 are significantly higher in obese/diabetic animal models compared to normal controls. Furthermore, CTRP5 may be a putative biomarker for mitochondrial dysfunction. Defects in C1QTNF5 are a cause of late-onset retinal degeneration (LORD).

Supplier: Adipogen

CD271 (p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR; NGFR) is a type I transmembrane protein, expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells and melanocytes. The extracellular portion contains four TNFR-Cys repeats that form the binding domain for its ligands, (NGF, BDNF, NTF3 and NTF4). The intracellular portion of CD271 contains a death domain, which interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9, to promote cell apoptosis and to regulate cell differentiation and neurogenesis.

Supplier: Adipogen

Annexin V is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Annexin V competes for phosphatidylserine binding sites (e.g. platelets) with prothrombin or coagulation factors and inhibis the activity of phospholipase A1. Antibodies directed against annexin V are found in patients with a disease called the antiphospholipid syndrome(APS), a thrombophilic disease associated with autoantibodies against phospholipid compounds. Annexin V is used as a probe in the "annexin V affinity assay" to detect cells that have expressed phosphatidylserine on the cell surface, a feature found in apoptosis and other forms of cell death.

Supplier: Adipogen

Annexin V is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Annexin V competes for phosphatidylserine binding sites (e.g. platelets) with prothrombin or coagulation factors and inhibis the activity of phospholipase A1. Antibodies directed against annexin V are found in patients with a disease called the antiphospholipid syndrome(APS), a thrombophilic disease associated with autoantibodies against phospholipid compounds. Annexin V is used as a probe in the "annexin V affinity assay" to detect cells that have expressed phosphatidylserine on the cell surface, a feature found in apoptosis and other forms of cell death.

Supplier: Adipogen

The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines, and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

Supplier: Adipogen

The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines, and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

Supplier: Adipogen

Expression of PROX1 in blood endothelial cells induces expression of other lymphatic marker genes. Together with podoplanin, PROX1 can be used to reliably distinguish lympathic vessels from blood vessels. PROX1 is expressed in CNS, eye, pancreas, liver and heart, and it is one of the most specific and reliable markers for lymphatic endothelial cells.

Supplier: Adipogen

The human CD1 genetic locus consists of five closely related genes. Three of the gene products (CD1a, CD1b and CD1c) have been officially clustered using antibodies and are expressed on cortical thymocytes, a subset of B cells, and on most professional antigen presenting cells. CD1 molecules have a specialized lipid antigen-presenting function and it is unlikely that they present conventional peptide antigens. CD1 may also be involved in costimulation.

Supplier: AZENTA US, INC

The gas permeable heat seal is made from a woven material and is designed for use in cell culture, due to its porous nature. Suitable for cell culture, overnight incubations, as well as insect and seed storage.

Supplier: BIOASSAY SYSTEMS

A reagent kit that allows our customers to develop their own cell-based ELISA. All that is required is a primary rabbit antibody (Ab1).

Supplier: Diversified Woodcrafts

An instructor's desk constructed of solid oak, oak and hardwood veneers, this unit serves as a complete demonstration center offering a spacious work surface.

Supplier: Rockland Immunochemical

Green Fluorescent Protein (GFP) is a 27 kDa protein produced from the jellyfish Aequorea victoria, which emits green light (emission peak at a wavelength of 509nm) when excited by blue light. GFP is an important tool in cell biology research. GFP is widely used enabling researchers to visualize and localize GFP-tagged proteins within living cells without the need for chemical staining. GFP Antibody is ideal for Cell Biology, Neuroscience and Cancer research.

Supplier: Stemcell Technologies

Mouse monoclonal IgG1, kappa isotype control antibody, APC-conjugated.

Supplier: Stemcell Technologies

Mouse monoclonal IgG3, kappa isotype control antibody, PE-conjugated.

Supplier: Stemcell Technologies

Mouse monoclonal IgG3, kappa isotype control antibody, Alexa Fluor® 488-conjugated.

Supplier: Stemcell Technologies

Mouse monoclonal IgG2b, kappa isotype control antibody, biotin-conjugated.

Supplier: Stemcell Technologies

Rat monoclonal IgG1, kappa isotype control antibody, APC-conjugated.

Supplier: Biotium

The DiO/DPA system detects cytoplasmic membrane potential changes using the principle of fluorescence resonance energy transfer (FRET), where DiO is a “stationary” FRET donor while DPA acts as a potentiometric FRET acceptor. The DiO/DPA system has been reported to produce a fluorescence signal change of >56% in HEK-293 cells and >25% in neuronal cultures and brain slices per 100 mV membrane potential change.

Supplier: Biotium

CD9 (clone HI9a) is a validated mouse monoclonal antibody that recognizes the human tetraspanin protein CD9. The antibody belongs to the Biotium Choice list of select antibodies that have been validated and optimized in-house for optimal performance.

Supplier: 3M Healthcare

3M™ Aqua–Pure™ Whole House Sanitary Quick–Change Replacement Water Filter Cartridge AP917HD for the AP903 system as an activated carbon filter with a nominal heavy duty particulate reduction rating of 5 µm and a 100000 gallon capacity. This cartridge design is suitable for use on both chlorinated (municipal) and non–chlorinated (well water) systems.

Supplier: 3M Healthcare

3M™ Aqua–Pure™ Under Sink Reverse Osmosis Replacement Water Filter Cartridge AP5527 is a multi–stage reverse osmosis replacement water filter set of two cartridges that is for use with the NSF certified AP–RO5500 reverse osmosis system. This set of cartridges, as part of the system, is the pre–filter and post filter which reduces particulate, chlorine taste and odor.

Supplier: 3M Healthcare

3M™ Aqua–Pure™ Under Sink Full Flow Replacement Water Filter Cartridge AP Easy C–Cyst–FF is one option in a complete product portfolio delivering cleaner, clearer drinking water. This replacement water filter cartridge is NSF listed to reduce particulate, chlorine taste, odor and parasitic protozoan cysts. The C–Cyst–FF cartridge is for use with the AP Easy Cyst–FF water filtration system.

Supplier: Cloud-Clone

This assay has high sensitivity and excellent specificity for detecting Human TMEM173 (Transmembrane Protein 173). The assay range is from 0.156 to 10 ng/ml (Sandwich kit) with a sensitivity of 0.055 ng/ml. There is no detectable cross-reactivity with other relevant proteins. Activity loss rate and accelerated stability test ect have been conducted to guarantee the best performance of the products after long storage and delivery.

Supplier: TCI America

CAS Number: 72-57-1 MDL Number: MFCD00003969 Molecular Formula: C34H28N6O14S4 Molecular Weight: 960.79 Form: Crystal Color: Deep Green

Supplier: Rockland Immunochemical

DRGX, also known as DRG11 or PRRXL1, is a paired homeodomain transcription factor, and was initially cloned from a differential hybridization screen aimed at identifying dorsal root ganglia (DRG)-specific genes. DRGX is a key regulator of the differentiation of the spinal cord neuronal circuit dedicated to the processing of nociceptive information. DRGX is also important for the formation of the whisker-related somatosensory maps in the principal sensory nucleus of the trigeminal nerve, thalamus and somatosensory cortex.

Supplier: Rockland Immunochemical

The guanylate-binding proteins (GBPs) are a family of interferon-induced GTP-binding proteins function in innate immunity against microbial and viral pathogens. In humans, there are seven GBPs from hGBP1 to hGBP7. Human GBP1 and GBP2 have been shown to exhibit antiviral activity as well as being able to regulate the inhibition of proliferation and invasion of endothelial cells in response to interferon (IFN). GBP5 promotes selective NALP3 inflammasome responses to pathogenic bacteria and soluble but not crystalline inflammasome priming agents.