5527 Results for: "Signal Transduction"

Supplier: MP Biomedicals

Protein kinase C inhibitor (IC50 = 50-200 µM depending on assay conditions in MCF-7 cells or IC50 = 100 µM in rat brain). The PKC inhibition is also dependent on the phosopholipid concentration. Also inhibits both calmodulin-dependent and calmodulin-independent Ca2+-, Mg2+-ATPase. Tamoxifen is a selective estrogen response modifier (SERM), anti-angiogenetic factor. It is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells.
Tamoxifen has been used to facilitate the recombination of ect2flox allele in mouse organs. It has also been used to study its effect on lipopolysaccharide (LPS)-induced microglial activation
Tamoxifen is a Protein kinase C inhibitor. It induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.

Supplier: Biotium

CD3e (Clone SK7) is a mouse monoclonal antibody derived from the extracellular domain of the CD3 epsilon chain. This antibody belongs to the Biotium Choice list of select antibodies that have been validated and optimized in-house for optimal performance. The antibody is available conjugated to either a CF® Dye or Astral™ tandem dye. They are supplied in PBS, 0.1% BSA, 0.05% azide.

Supplier: ReVacc Scientific

This pseudotyped virus uses recombinant Vesicular Stomatitis Virus (rVSV) to carry the S protein mutated from D (Asp) to G (Gly) at site of 614 of SARS-CoV-2 (GenBank: MN908947), with 18-aa cytoplasmic tail truncation for optimal infection.

Supplier: Biotium

CD284 / TLR4 Monoclonal antibody, Clone: TLR4/230, Host: Mouse, Conjugate: CF405S, Species reactivity: Guinea Pig, Monkey, Pig, Dog, Rat, Human, Immunogen: Recom human TLR4 protein, Isotype: IgG2a, kappa, Synonyms:ARMD10, Application: IF, Size: 100uL

Supplier: Boster Biological Technology

Rabbit IgG polyclonal antibody for SHC-transforming protein 1(SHC1) detection. Tested with WB, IHC-P, IHC-F in Human;Mouse;Rat.

Supplier: Stemcell Technologies

Mouse monoclonal IgG2a antibody against human CD51 (integrin αV), PE­conjugated.

Supplier: ReVacc Scientific

This pseudotyped virus uses recombinant vesicular stomatitis virus (rVSV) to carry the S protein of SARS-CoV-2 (GenBank: MN908947) with multiple mutations initially identified in variant of B.1.617.2 (Delta strain), and 18-aa cytoplasmic tail truncation for optimal infection.

Supplier: ReVacc Scientific

This pseudotyped virus uses recombinant Vesicular Stomatitis Virus (rVSV) to carry the S protein of SARS-CoV-2 (GenBank: MN908947) (Wuhan strain or Wild type strain), with 18-aa cytoplasmic tail truncation for optimal infection.

Supplier: Biotium

CD37 Monoclonal antibody, Clone: IPO-24, Host: Mouse, Conjugate: CF405S, Species reactivity: Human, Immunogen: Spleen cells of a patient with hairy cell leukemia, Isotype: IgG2b, kappa, Synonyms:Cell differentiation antigen 37, Application: IF, FC, Size: 100uL

Supplier: Stemcell Technologies

Mouse monoclonal IgG2a antibody against human CD51 (integrin αV), FITC­conjugated.

Supplier: Biotium

CD21 Monoclonal antibody, Clone: FR5A10, Host: Mouse, Conjugate: CF405S, Species reactivity: Human, Isotype: IgG3, kappa, Synonyms:CD21; Complement C3d receptor (C3DR); Complement Receptor type 2 (CR2); CVID7, Application: IF, IHC (frozen), FC, Size: 100uL

Supplier: BioVendor

Uromodulin (Tamm-Horsfall protein, UMOD) is approx. 85 kDa glycoprotein that is produced in the thick ascending limb of Henle's loop and early distal convoluted tubules of the nephron.

Supplier: Stemcell Technologies

Rat monoclonal IgG2b antibody against mouse CD25, unconjugated.

Supplier: Stemcell Technologies

Mouse monoclonal IgG2a antibody against human CD51 (integrin αV), biotin-conjugated.

Supplier: Stemcell Technologies

Mouse monoclonal IgG2a antibody against human CD51 (integrin αV), unconjugated.

Supplier: BioVendor

This assay will help to clarify the possible diagnostic and prognostic value of circulating sTNF-R (60 kDa) in various neoplastic and inflammatory diseases.

Supplier: Stemcell Technologies

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD90 (Thy-1), PE-conjugated.

Supplier: Biotium

CD16 (Clone 3G8) is a mouse monoclonal antibody that recognizes IgG receptor CD16, also known as FC gamma receptor III. This antibody belongs to the Biotium Choice list of select antibodies that have been validated and optimized in-house for optimal performance. The antibody is available conjugated to CF® Dyes and Astral™ tandem dyes. They are supplied in PBS, 0.1% BSA, 0.05% azide.

Supplier: Cayman Chemical Company

Interferon regulatory factor 3 (IRF3) is a member of the IRF family. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection, functioning as a molecular switch for antiviral activity. Double-stranded RNA generated during a viral infection leads to IRF3 activation by serine/threonine phosphorylation by TBK1 or IKBKE kinases, which induces a conformational change leading to its dimerization, nuclear localization, and association with CREBBP. The complex, known as DRAF1, activates transcription interferons alpha and beta, as well as other interferon-induced genes. These genes play a critical role in type 1 interferon (IFN)-dependent immune response. A recent study shows phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF recruits and specifies IRF3 phosphorylation and activation by the serine/threonine-protein kinase TBK1, thereby inducing the production of type-1 interferons.

Supplier: Stemcell Technologies

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD90 (Thy-1), PerCP-Cy5.5-conjugated.

Supplier: Biotium

CD16 (Clone 3G8) is a mouse monoclonal antibody that recognizes IgG receptor CD16, also known as FC gamma receptor III. This antibody belongs to the Biotium Choice list of select antibodies that have been validated and optimized in-house for optimal performance. The antibody is available conjugated to CF® Dyes and Astral™ tandem dyes. They are supplied in PBS, 0.1% BSA, 0.05% azide.

Supplier: Stemcell Technologies

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD90 (Thy-1), APC-conjugated.

Supplier: Prosci

As a RNA-binding protein, KHDRBS3 plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. KHDRBS3 may play a role as a negative regulator of cell growth. It inhibits cell proliferation and involved in splice site selection of vascular endothelial growth factor. It induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. It also involved in post-transcriptional regulation of HIV-1 gene expression.

Supplier: Stemcell Technologies

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD90 (Thy-1), FITC-conjugated.

Supplier: Stemcell Technologies

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD90 (Thy-1), biotin-conjugated.

Supplier: Biotium

CD16 (Clone 3G8) is a mouse monoclonal antibody that recognizes IgG receptor CD16, also known as FC gamma receptor III. This antibody belongs to the Biotium Choice list of select antibodies that have been validated and optimized in-house for optimal performance. The antibody is available conjugated to CF® Dyes and Astral™ tandem dyes. They are supplied in PBS, 0.1% BSA, 0.05% azide.

Supplier: ReVacc Scientific

This pseudotyped virus uses recombinant Vesicular Stomatitis Virus (rVSV) to carry spike protein of SARS-CoV-2 (GenBank: MN908947) with multiple mutations identified in Beta variant: L18F, D80A, D215G, L242-244del, R246I, K417N, E484K, N501Y, D614G, and A701V. The spike protein has a 18-aa cytoplasmic tail truncation for optimal infection.

Supplier: Stemcell Technologies

Mouse monoclonal IgG2a antibody against human, rhesus, cynomolgus CD14, unconjugated.

Supplier: Stemcell Technologies

Mouse monoclonal IgG2a antibody against human, rhesus, cynomolgus CD14, biotin-conjugated.

Supplier: Stemcell Technologies

Mouse monoclonal IgG2a antibody against human, rhesus, cynomolgus CD14, FITC-conjugated.