21681 Results for: "Ricca Natural Isolates"

Supplier: Biosensis

FUNCTION: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. SUBCELLULAR LOCATION: Cytoplasm; cytosol. Cell membrane. Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components. ALTERNATIVE PRODUCTS: 8 named isoforms produced by alternative splicing. Additional isoforms seem to exist. Isoforms differ from each other by the presence or absence of up to 5 of the 15 exons. One of these optional exons contains the additional tau/MAP repeat. TISSUE SPECIFICITY: Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system. DEVELOPMENTAL STAGE: Four-repeat (type II) tau is expressed in an adult-specific manner and is not found in fetal brain, whereas three-repeat (type I) tau is found in both adult and fetal brain. DOMAIN: The tau/MAP repeat binds to tubulin. In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments and straight filaments, mainly composed of hyperphosphorylated forms of Microtubule-associated protein Tau. Defects in Microtubule-associated protein Tau are a cause of frontotemporal dementia and parkinsonism linked to chromosome 17, as well as a number of other neurodegenerative diseases.

Supplier: Biosensis

The Lamin proteins are members of the intermediate filament protein family but are located inside the nucleus rather than in the cytoplasm (1). The lamins function as skeletal components tightly associated with the inner nuclear membrane. Originally the proteins of the nuclear cytoskeleton were named Lamin A, B and C, from top to bottom as visualized on SDS-PAGE gels. Subsequently it was found that Lamins A and C were coded for by a single gene (2), while the Lamin B band may contain two proteins encoded by two genes now called Lamin B1 and Lamin B2. Lamin A has a mass of about 74kDa while Lamin C is 65kDa. The Lamin A protein includes 98 amino acids missing from Lamin C, while Lamin C has a C-terminal 6 amino acid peptide not present in Lamin A. Apart from these regions Lamin A and C are identical so that antibodies raised against either protein are likely to cross react with the other, as is the case with this monoclonal. Lamin polymerization and depolymerization is regulated by phosphorylation by cyclin dependent protein kinase 1 (CDK1), the key component of "maturation promoting factor", the central regulator of cell division. Activity of this kinase increases during cell division and is responsible for the breakdown of the nuclear lamina. Mutations in the LMNA gene are associated with several serious human diseases, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease type 2B1, and Hutchinson-Gilford progeria syndrome. This family of diseases belong to a larger group which are often referred to as Laminopathies, though some laminopathies are associated in defects in Lamin B1, B2 or one or other of the numerous nuclear lamina binding proteins. A truncated version of lamin A, commonly known as progerin, causes Hutchinson-Gilford progeria syndrome, a form of premature aging (3).

Supplier: Thermo Scientific Chemicals

MDL: MFCD00065606 Beilstein Registry No.: 5158059 Optical Rotation: +5.5°C (c=5 in 5N HCl)

Supplier: Thermo Scientific Chemicals

L(+)-Histidine monohydrochloride monohydrate 99%

Supplier: Biosensis

FUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1/Tip60 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. FUNCTION: Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. Rat and mouse beta-amyloid peptides bind only weakly transient metals and have little reducing activity due to substitutions of transient metal chelating residues. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation (By similarity). FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. SUBUNIT: Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, SHC1, Numb and Dab1. Binding to Dab1 inhibits its serine phosphorylation. Also interacts with GPCR-like protein BPP, FPRL1, APPBP1, IB1, KNS2 (via its TPR domains), APPBP2 (via BaSS) and DDB1. In vitro, it binds MAPT via the MT-binding domains. Associates with microtubules in the presence of ATP and in a kinesin-dependent manner. Interacts, through a C-terminal domain, with GNAO1. Amyloid beta-42 binds CHRNA7 in hippocampal neurons. Beta-amyloid associates with HADH2. TISSUE SPECIFICITY: different isoforms in different tissues: kidney. brain. liver. hippocampus, substania nigra pars compacta and cerebellum. In the cerebellum, all the isoforms are abundantly expressed in Purkinje cells.

Supplier: Thermo Scientific Chemicals

Sodium-L(+)-glutamate monohydrate 98+%

Supplier: LGC Standards

2-METHYL-2 4-PENTANEDIOL 1ML

Supplier: CELLTREAT Scientific Products

Oak ridge centrifuge tubes for high-speed centrifugation. Applications include separating liquid from cells, sedimenting particles, or extracting nucleic acids.

Supplier: CELLTREAT Scientific Products

Oak ridge centrifuge tubes for high-speed centrifugation. Applications include separating liquid from cells, sedimenting particles, or extracting nucleic acids.

Supplier: CELLTREAT Scientific Products

Micro centrifuge tubes for tasks in tissue culture, molecular biology, or biochemistry where small sample volumes are needed, such as processing cell cultures or preparing samples.

Supplier: CELLTREAT Scientific Products

Centrifuge filters use centrifugal force to separate different components within a liquid or liquid mixture.

Supplier: CELLTREAT Scientific Products

Micro centrifuge tubes for tasks in tissue culture, molecular biology, or biochemistry where small sample volumes are needed, such as processing cell cultures or preparing samples.

Supplier: CELLTREAT Scientific Products

Centrifuge filters use centrifugal force to separate different components within a liquid or liquid mixture.

Supplier: CELLTREAT Scientific Products

Multiple and single cavity reagent reservoirs for efficient and organized liquid handling, particularly in repetitive or robotic liquid transfer tasks.

Supplier: CELLTREAT Scientific Products

Multiple and single cavity reagent reservoirs for efficient and organized liquid handling, particularly in repetitive or robotic liquid transfer tasks.

Supplier: CELLTREAT Scientific Products

Metal-free tubes are great for analytical testing such as water, environment, and food/beverage.

Supplier: CELLTREAT Scientific Products

Metal-free tubes are great for analytical testing such as water, environment, and food/beverage.

Supplier: CELLTREAT Scientific Products

Centrifuge tubes for scientific research and medical laboratories to separate materials based on their density by spinning the tube at high speeds, causing the heavier components to settle at the bottom of the tube.

Supplier: CELLTREAT Scientific Products

Centrifuge tubes for scientific research and medical laboratories to separate materials based on their density by spinning the tube at high speeds, causing the heavier components to settle at the bottom of the tube.

Supplier: CELLTREAT Scientific Products

Bio-reaction tubes are suitable for use in the high-throughput condition optimization process for suspension cell culture, including research and clonal selection of cell lines, culture medium optimization, and recombinant protein development.

Supplier: CELLTREAT Scientific Products

Bio-reaction tubes are suitable for use in the high-throughput condition optimization process for suspension cell culture, including research and clonal selection of cell lines, culture medium optimization, and recombinant protein development.