95291 Results for: "Plant+and+Fungi+Genetics+Lab+Activities"

Supplier: Aladdin Scientific

Chenodeoxycholic Acid, Free Acid and its 7β-isomer ursodeoxycholic acid are potent (nanomolar affinity) selective inhibitors of DD2 (AKR1C2). These compounds were non-competitive inhibitors of AKR1D1 yielding Ki values of 3.2 μM for chenodeoxycholic acid. This chemical is a hydrophobic primary bile acid, which increases intracellular Ca2+ in rat hepatocyte couplets. Studies indicate that Chenodeoxycholic Acid induces apoptosis through a PKC dependent pathway.

Supplier: Aladdin Scientific

BMS-911543 is a selective small-molecule inhibitor of JAK2 with IC50 value of 1.1 nM .BMS-911543 is a reversible pyrrolopyridine ATP-competitive JAK2 inhibitor with a high selectivity. In the in vitro assay using human recombinant JAK enzyme, BMS-911543 displays an IC50 value of 1.1 nM against JAK2 and the Ki value is 0.48 nM.

Supplier: Aladdin Scientific

BMS-911543 is a selective small-molecule inhibitor of JAK2 with IC50 value of 1.1 nM .BMS-911543 is a reversible pyrrolopyridine ATP-competitive JAK2 inhibitor with a high selectivity. In the in vitro assay using human recombinant JAK enzyme, BMS-911543 displays an IC50 value of 1.1 nM against JAK2 and the Ki value is 0.48 nM.

Supplier: Aladdin Scientific

Biphenyl-4,4′-dicarboxylic acid (BPDC) belongs to the class of monomers known as aromatic dicarboxylic acids. It is used to prepare BPDC-based polymers, which exhibit excellent thermal stability, making them suitable for applications where high-temperature resistance is required. These polymers also demonstrate high electrical insulation properties due to their low dielectric constant and high breakdown strength. They find applications in the electrical and electronics industry for insulation, encapsulation, and fabrication of high-performance electronic devices.

Supplier: Aladdin Scientific

Biphenyl-4,4′-dicarboxylic acid (BPDC) belongs to the class of monomers known as aromatic dicarboxylic acids. It is used to prepare BPDC-based polymers, which exhibit excellent thermal stability, making them suitable for applications where high-temperature resistance is required. These polymers also demonstrate high electrical insulation properties due to their low dielectric constant and high breakdown strength. They find applications in the electrical and electronics industry for insulation, encapsulation, and fabrication of high-performance electronic devices.

Supplier: Aladdin Scientific

27-hydroxycholesterol (27-HC) is synthesized by cholesterol under the action of sterol 27-hydroxylase in the liver. It is an abundant oxidizing sterol in the cyclic range of 0.15 to 0.73 μM. 27-HC is a substrate for bile synthesis. 27-Hydroxycholesterol, an oxysterol secreted from macrophages, has been shown to be capable of passing through the blood-brain barrier and entering the circulation via the brain. This compound has been shown to be a cholesterol oxidation metabolite that causes an increase in levels of GADD 153 and caspase-12 in ARPE-19 cells In vitro.

Supplier: Aladdin Scientific

27-hydroxycholesterol (27-HC) is synthesized by cholesterol under the action of sterol 27-hydroxylase in the liver. It is an abundant oxidizing sterol in the cyclic range of 0.15 to 0.73 μM. 27-HC is a substrate for bile synthesis. 27-Hydroxycholesterol, an oxysterol secreted from macrophages, has been shown to be capable of passing through the blood-brain barrier and entering the circulation via the brain. This compound has been shown to be a cholesterol oxidation metabolite that causes an increase in levels of GADD 153 and caspase-12 in ARPE-19 cells In vitro.

Supplier: Aladdin Scientific

AM 095 AM095 is an antagonist of the LPA type 1 receptor with IC50 values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively. TargetsLPA1 receptorIn vitroAM095 is a potent LPA1 receptor antagonist because it inhibited GTPγS binding to Chinese hamster ovary (CHO) cell membranes overexpressing recombinant human or mouse LPA1 with IC50 values of 0.98 and 0.73 μM, respectively, and exhibited no LPA1 agonism. In functional assays, AM095 inhibited LPA-driven chemotaxis of CHO cells overexpressing mouse LPA1 (IC50=778 nM) and human A2058 melanoma cells (IC50=233 nM).

Supplier: Aladdin Scientific

AT13148 is an oral, ATP-competitive, multi-AGC kinaseinhibitor withIC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM forAkt1/2/3,p70 S6 K, PKA, andROCKI/II, respectively. Phase 1. TargetsPKA (Cell-free assay); ROCK2 (Cell-free assay); ROCK1 (Cell-free assay); p70 S6 K (Cell-free assay); Akt1 (Cell-free assay) 15565,3 nM; 4 nM; 6 nM; 8 nM; 38 nMIn vitroAT13148, as a multi-AGC kinase inhibitor, potently inhibits proliferation with GI50 values of 1.5 to 3.8 μM across a selected panel of cancer cell lines with deregulation of PI3 K-AKT-mTOR or RAS-RAF pathways.

Supplier: Aladdin Scientific

AT13148 is an oral, ATP-competitive, multi-AGC kinaseinhibitor withIC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM forAkt1/2/3,p70 S6 K, PKA, andROCKI/II, respectively. Phase 1. TargetsPKA (Cell-free assay); ROCK2 (Cell-free assay); ROCK1 (Cell-free assay); p70 S6 K (Cell-free assay); Akt1 (Cell-free assay) 15565,3 nM; 4 nM; 6 nM; 8 nM; 38 nMIn vitroAT13148, as a multi-AGC kinase inhibitor, potently inhibits proliferation with GI50 values of 1.5 to 3.8 μM across a selected panel of cancer cell lines with deregulation of PI3 K-AKT-mTOR or RAS-RAF pathways.

Supplier: Aladdin Scientific

AZD-5153 6-hydroxy-2-naphthoic acid AZD-5153 6-hydroxy-2-naphthoic acid (HNT salt) is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4. AZD-5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes. NSD3, via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes.TargetsFL-BRD4 (Cell-based assay) 5 nMIn vitroUnlike previously described monovalent inhibitors, AZD5153 ligates two bromodomains in BRD4 simultaneously. AZD5153 treatment markedly affects transcriptional programs of MYC, E2F, and mTOR. Of note, mTOR pathway modulation is associated with cell line sensitivity to AZD5153.