95291 Results for: "Plant+and+Fungi+Genetics+Lab+Activities"

Supplier: Aladdin Scientific

Brigatinib (AP26113) Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits IGF-1R, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy. Targets: ALK (Cell-free assay); ROS1 (Cell-free assay); FLT3 (Cell-free assay); IGF1R (Cell-free assay); EGFR(C797S/del19) (cell-based) 16489,0.37 nM; 1.9 nM; 2.1 nM; 24.9 nM; 39.9 nM in vitro Beyond ALK, IGF1R, and InsR, brigatinib also potently inhibits FLT3 and ROS1 with IC50 values of 2.1 and 1.9 nM, respectively.

Supplier: Aladdin Scientific

RNA phosphoramidites, along with RNA CPG, and analogous to DNA synthesis support the synthesis of sequence-specific RNA oligonucleotides for RNA interference (RNAi) and can be used in target validation and other drug development techniques. Modern phosphoramidite-mediated synthesis has enabled routine high-yielding preparations of RNA oligonucleotides.

Supplier: Aladdin Scientific

Cyclobutane-1,2,3,4-tetracarboxylic dianhydride was used to synthesize polyimide films and poly(amic acid) having liquid crystal alignment layers. Reactant for: ?

Supplier: Aladdin Scientific

Cyclobutane-1,2,3,4-tetracarboxylic dianhydride was used to synthesize polyimide films and poly(amic acid) having liquid crystal alignment layers. Reactant for: ?

Supplier: Aladdin Scientific

C-170 is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING).

Supplier: Aladdin Scientific

RNA phosphoramidites, along with RNA CPG, and analogous to DNA synthesis support the synthesis of sequence-specific RNA oligonucleotides for RNA interference (RNAi) and can be used in target validation and other drug development techniques. Modern phosphoramidite-mediated synthesis has enabled routine high-yielding preparations of RNA oligonucleotides.

Supplier: Aladdin Scientific

C-170 is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING).

Supplier: Aladdin Scientific

Azide-PEG5-Tos (Azido-PEG5-OTs) is a cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).

Supplier: Aladdin Scientific

Product Describtion:Copper(II) phthalocynaine (CuPc) is a metal phthalocyanine dye that acts as a p-type semiconductor. It has a charge mobility of 10 to 4 cm2/Vs.

Supplier: Aladdin Scientific

Brij L23 is an ethoxylated (23) natural fatty alcohol, based on lauryl alcohol. This naturally derived surfactant offers a number of functional benefits including wetting and high foaming to a variety of applications.

Supplier: Aladdin Scientific

Product Describtion:Copper(II) phthalocynaine (CuPc) is a metal phthalocyanine dye that acts as a p-type semiconductor. It has a charge mobility of 10 to 4 cm2/Vs.

Supplier: Aladdin Scientific

Brij L23 is an ethoxylated (23) natural fatty alcohol, based on lauryl alcohol. This naturally derived surfactant offers a number of functional benefits including wetting and high foaming to a variety of applications.

Supplier: Biotix

Designed with Flexfit™ to lower necessary insertion and ejection force by ~70% for a secure seal. Manufactured with pure resin, made of virgin polypropylene.

Supplier: Biotix

Designed with Flexfit™ to lower necessary insertion and ejection force by ~70% for a secure seal. Manufactured with pure resin, made of virgin polypropylene.

Supplier: Aladdin Scientific

Benzamidine and its derivatives serve as inhibitors of serine protease enzymes, namely tryptase, thrombin, and KLK11 (tripsin-like enzymes). The strong affinity of benzamidine for these enzymes has been exploited to crystallize and study spectra of thrombin complexes.

Supplier: Aladdin Scientific

Benzamidine and its derivatives serve as inhibitors of serine protease enzymes, namely tryptase, thrombin, and KLK11 (tripsin-like enzymes). The strong affinity of benzamidine for these enzymes has been exploited to crystallize and study spectra of thrombin complexes.

Supplier: Aladdin Scientific

Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agentA DNA alkylating and cross-linking agent used in the treatment of brain tumors and various other malignant neoplasmsGeneral description：Carmustine is a mustard gas related β-chloro-nitrosourea compound, which is used in chemotherapy. It inhibits DNA replication and DNA transcription.

Supplier: Aladdin Scientific

Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agentA DNA alkylating and cross-linking agent used in the treatment of brain tumors and various other malignant neoplasmsGeneral description：Carmustine is a mustard gas related β-chloro-nitrosourea compound, which is used in chemotherapy. It inhibits DNA replication and DNA transcription.

Supplier: Aladdin Scientific

Beryllium fluoride (BeF2) has a variety of applications across different fields. In the study of thermodynamic analysis of batteries, it is used to determine the energy density. In protein crystallography, it is used as a substitute for phosphate and in conjunction with ADP to inhibit protein action and crystallize proteins in the bound state.

Supplier: Aladdin Scientific

Calcium hydroxide can be used to prepare nanocrystalline hydroxyapatite by sonochemical technology. Ca (OH) 2 can be used as a catalyst for pine pyrolysis in a fixed bed reactor.Application: Mortar, plasters, cements, gas manufacturing to remove ammonia, in lubricants, water softening, petrochemicals, soil conditioner, paving materialsCalcium hydroxide is used as a flocculant in water and sewage treatment.

Supplier: Aladdin Scientific

Calcium hydroxide can be used to prepare nanocrystalline hydroxyapatite by sonochemical technology. Ca (OH) 2 can be used as a catalyst for pine pyrolysis in a fixed bed reactor.Application: Mortar, plasters, cements, gas manufacturing to remove ammonia, in lubricants, water softening, petrochemicals, soil conditioner, paving materialsCalcium hydroxide is used as a flocculant in water and sewage treatment.

Supplier: Aladdin Scientific

AZD3965 AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 ( MCT1 ) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1. TargetsMCT1in vitroin lymphoma cell lines that preferentially express MCT1, AZD3965 potently inhibits lactate transport and cell growth.

Supplier: Aladdin Scientific

AZD3965 AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 ( MCT1 ) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1. TargetsMCT1in vitroin lymphoma cell lines that preferentially express MCT1, AZD3965 potently inhibits lactate transport and cell growth.

Supplier: Aladdin Scientific

Curcumin is a yellow-colored polyphenol obtained from the rhizome ofCurcuma longaL.

Supplier: Aladdin Scientific

Curcumin is a yellow-colored polyphenol obtained from the rhizome ofCurcuma longaL.

Supplier: FUJIFILM IRVINE SCIENTIFIC WAKO CHE

Y-27632 is reagent for cell culture applications, including human ES/iPS cell culture. It enhances cell viability and reduces cell death during passaging and cryopreservation.

Supplier: FUJIFILM IRVINE SCIENTIFIC WAKO CHE

Y-27632 is reagent for cell culture applications, including human ES/iPS cell culture. It enhances cell viability and reduces cell death during passaging and cryopreservation.

Supplier: Aladdin Scientific

ARN-3236 ARN-3236 is a potent, orally available and selective inhibitor of salt-inducible kinase 2 (SIK2) with IC50 of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. ARN-3236 induces apoptosis in cancer cells. TargetsSIK2 (Cell-free assay); SIK3 (Cell-free assay); SIK1 (Cell-free assay) 1 nM; 6.63 nM; 21.63 nMIn vitroSIK2 is overexpressed in approximately 30% of high grade serous ovarian cancers. ARN-3236 inhibits growth of 10 ovarian cancer cell lines at an IC50 of 0.8 to 2.6 μM, where the IC50 of ARN-3236 is inversely correlated with endogenous SIK2 expression (Pearson’s r = −0.642, P = 0.03). ARN-3236 enhances sensitivity to paclitaxel in 8 of 10 cell lines. In at least three cell lines a synergistic interaction is observed.

Supplier: Aladdin Scientific

ARN-3236 ARN-3236 is a potent, orally available and selective inhibitor of salt-inducible kinase 2 (SIK2) with IC50 of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. ARN-3236 induces apoptosis in cancer cells. TargetsSIK2 (Cell-free assay); SIK3 (Cell-free assay); SIK1 (Cell-free assay) 1 nM; 6.63 nM; 21.63 nMIn vitroSIK2 is overexpressed in approximately 30% of high grade serous ovarian cancers. ARN-3236 inhibits growth of 10 ovarian cancer cell lines at an IC50 of 0.8 to 2.6 μM, where the IC50 of ARN-3236 is inversely correlated with endogenous SIK2 expression (Pearson’s r = −0.642, P = 0.03). ARN-3236 enhances sensitivity to paclitaxel in 8 of 10 cell lines. In at least three cell lines a synergistic interaction is observed.

Supplier: Aladdin Scientific

Chenodeoxycholic Acid, Free Acid and its 7β-isomer ursodeoxycholic acid are potent (nanomolar affinity) selective inhibitors of DD2 (AKR1C2). These compounds were non-competitive inhibitors of AKR1D1 yielding Ki values of 3.2 μM for chenodeoxycholic acid. This chemical is a hydrophobic primary bile acid, which increases intracellular Ca2+ in rat hepatocyte couplets. Studies indicate that Chenodeoxycholic Acid induces apoptosis through a PKC dependent pathway.