94905 Results for: "Plant+and+Fungi+Genetics+Lab+Activities"

Supplier: Prosci

Macrophage CSF, also known as CSF1, is produced by monocytes, fibroblasts and endothelial cells. It stimulates the formation of macrophage colonies, enhances antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages, and inhibits bone resorption by osetoclasts. Natural human MCSF is a dimeric glycoprotein of 70-90 kD molecular weight, existing in multiple glycosylation forms. It binds to a 165 kD glycoprotein of the receptor tyrosine kinase subclass III, a family that includes the receptors for platelet derived growth factor (PDGF) and stem cell factor (SCF).

Supplier: Rockland Immunochemical

RIPA (Radio-Immunoprecipitation Assay) Lysis Buffer enables rapid, efficient cell lysis and solubilization of proteins from both adherent and suspension cultured mammalian cells.

Supplier: Aladdin Scientific

Belvarafenib (GDC5573, HM95573, RG6185) is a selective and orally bioavailablepan-RAF kinaseinhibitor with IC50 values of 41 nM, 7 nM and 2 nM for BRAF WT, BRAF(V600E) and CRAF kinases, respectively.Targets: CRAF (Cell-free assay); BRAF V600E (Cell-free assay); BRAF WT (Cell-free assay) 2 nM; 7 nM; 41 nM in vitro Biochemically assayed for over 120 kinases, HM95573 shows the high selectivity toward BRAF mutant and CRAF kinases. The half maximal inhibition concentrations (IC50) of HM95573 against BRAFWT, BRAFV600E and CRAF kinases are 41, 7 and 2 nM, respectively. The strongly inhibited kinases subsequent to RAF kinases appear to be CSF1R (44nM), DDR1 (77nM) and DDR2 (182 nM). HM95573 potently inhibits the growth of mutant BRAF melanoma cell lines such as A375 (IC50: 57 nM) and SK-MEL-28 (69 nM) and of mutant NRAS melanoma cell lines such as SK-MEL-2 (53 nM) and SK-MEL-30 (24 nM).

Supplier: LAMPIRE BIOLOGICAL LAB MS

BOVINE SERUMALBUMIN LYOPHILISED PH-7 1KG

Supplier: RAPID LAB INC MS

RMR6 MINITAGS BUT ONLY EA

Supplier: IBI Scientific

The IBI high throughput 96-Well PCR Clean-Up Kit is designed to recover or concentrate DNA fragments from PCR or other enzymatic reactions using an efficient 96-well binding plate system.

Supplier: Promega Corporation

The ADCC Reporter Bioassay provides a biologically relevant and specific MOA-based measure of ADCC V158 without the complex workflow and variability inherent in primary cell-based assays.

Supplier: Promega Corporation

The ADCC Reporter Bioassay provides a biologically relevant and specific MOA-based measure of ADCC V158 without the complex workflow and variability inherent in primary cell-based assays.

Supplier: Promega Corporation

The ADCC Reporter Bioassay provides a biologically relevant and specific MOA-based measure of ADCC V158 without the complex workflow and variability inherent in primary cell-based assays.

Supplier: BELL BROOK LABS MS

ASSAY TRANSCREENER CGAMP CGAS FP 10000

Supplier: BELL BROOK LABS MS

ASSAY TRANSCREENER ADP2 TR-FRET 10000

Supplier: BELL BROOK LABS MS

ASSAY SYSTEM CD38 1000

Supplier: Prosci

CD36 binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. As a coreceptor for TLR4-TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. [UniProt]

Supplier: Prosci

This mAb reacts with a CD32 (FcgRII) epitope (cluster-4). It displays a stronger reaction with Daudi than with U937 cells. The epitope is located in domain 2 of FcgRIIa. Its Fab'2 fragments block immune complex binding. CD32 (FcgRII) is a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes.

Supplier: Promega Corporation

The ADCC Bioassay F Variant Effector Cells, Propagation Model provides a biologically relevant and specific MOA-based measure of ADCC without the complex workflow and variability inherent in primary cell-based assays.

Supplier: Aladdin Scientific

AZD-5153 6-hydroxy-2-naphthoic acid AZD-5153 6-hydroxy-2-naphthoic acid (HNT salt) is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4. AZD-5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes. NSD3, via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes.TargetsFL-BRD4 (Cell-based assay) 5 nMIn vitroUnlike previously described monovalent inhibitors, AZD5153 ligates two bromodomains in BRD4 simultaneously. AZD5153 treatment markedly affects transcriptional programs of MYC, E2F, and mTOR. Of note, mTOR pathway modulation is associated with cell line sensitivity to AZD5153.

Supplier: Promega Corporation

The ADCC Reporter Bioassay provides a biologically relevant and specific MOA-based measure of ADCC V158 without the complex workflow and variability inherent in primary cell-based assays.

Supplier: BELL BROOK LABS MS

ASSAY TRANSCREENER ADP2 FI 10000ASSAY

Supplier: BELL BROOK LABS MS

ASSAY TRANSCREENER DAMP FP 1000ASSAY

Supplier: Electron Microscopy Sciences

Until now, LR White has been the most commonly used embedding media for materials due to the block hardness it offered, but there are difficulties associated with LR White

Supplier: BELL BROOK LABS MS

ASSAY TRANSCREENER UDP2 FP FAR RED 1000

Supplier: UNCHAINED LABS MS

PLATES HIGH LUNATIC OD 275 PK10

Supplier: UNCHAINED LABS MS

STRIPS HIGH LUNA PLATE FRAME OD 275 PK30

Supplier: UNCHAINED LABS MS

PLATES HIGH LUNATIC OD 275 PK40

Supplier: BELL BROOK LABS MS

TRANSCREENER CGAMP CGAS TR-FRET BUNDLE

Supplier: BELL BROOK LABS MS

ASSAY TRANSCREENER AMP2/GMP2 FP 10000

Supplier: BELL BROOK LABS MS

ASSAY TRANSCREENER UDP2 FP FAR 10000RED

Supplier: Stemcell Technologies

Heregulin-beta 1 also known as neuregulin-1 (NRG-1) is a member of the epidermal growth factor (EGF) family of growth factors and acts as a ligand for ErbB family receptor tyrosine kinases (Britsch et al.). Heregulin/neuregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3, and NRG4). Heregulin-beta 1 plays an important role during the development of the nervous system, heart, and mammary glands (Britsch). Heregulin-beta 1 is expressed in neuronal cells, and modulates cell growth and differentiation of the cells during development and wound healing (Mei and Xiong). It has been implicated through in vivo and in vitro studies that heregulin-beta 1/ErbB signaling is crucial for multiple aspects of cardiovascular development and protects the heart from ischemic injury (Odiete et al.). Heregulin-beta 1 also promotes invasiveness and metastasis of breast cancer cells (Hutcheson et al.). It has also been shown that heregulin-beta 1 has a role in the growth and maintenance of human embryonic stem cells (Wang et al.).

Supplier: Sartorius

These MCE series essential user interface balance was a large, high-contrast touch display with factory-installed essential weighing applications for easy operation.

Supplier: Cytiva

rProtein A Sepharose™ 4 Fast Flow is a well established antibody affinity medium is designed for the purification of monoclonal and polyclonal antibodies based on Sepharose™ Fast Flow platform. The recombinant protein A is produced in E.coli and engineered for an oriented coupling to giving a matrix with enhanced binding capacity. The epoxy-based coupling ensures low ligand leakage. The specificity of the recombinant protein A for the Fc region of IgG is similar to native protein A and provides excellent purification in one step. The high capacity, low ligand leakage and a well established base matrix makes rProtein A Sepharose™ Fast Flow ideal for purification of monoclonal antibodies at both laboratory and process scale.