1154 Results for: "NMR"

Supplier: Adipogen

Anti-hypercholestrolemic compound. Anti-inflammatory and immune-modulating effects. Anticancer compound. Chemopreventive. Cytostatic. Cell growth inhibitor. Antimutagenic. Potent in vitro antagonist of FXR (farnesoid X receptor). DNA polymerase beta inhibitor. Potent antioxidant, hypoglycemic and thyroid inhibiting agent. Anti-osteoarthritic. Decreases the expression of matrix metalloproteinases. Neuroprotective. Is used as a precursor for synthetic progesterone and vitamin D3 and is an intermediate in the biosynthesis of androgens, estrogens and corticoids.

Supplier: Adipogen

Sulforhodamine 101 sulfonyl chloride (also called Texas Red sulfonyl chloride) is a popular long wavelength amine-reactive rhodamine dye. Because the dye is quite unstable in water, reactions with amines in an aqueous solution must be carried out at low temperature (over ice or at 4°C) and usually at pH 8.5.

Supplier: Adipogen

Smooth muscle relaxant and vasodilator. Phosphodiesterase PDE10A inhibitor. Antiviral. Antipsychotic. Potential inducer of browning in WAT.

Supplier: Adipogen

Carbocyanine dyes, particularly thiacyanines such as DiSC3(3) can inhibit respiration and may therefore be relatively cytotoxic. 3,3'-dipropyl-thiadicarbocyanine iodide is sensitive to membrane potential, fluorescence response to depolarization depends on the staining concentration and detection method. Selected applications are: -Calcium channels and other ion transport systems -Mitochondrial activity -Neurons and brain tissue -Membrane potential in intact yeast cells

Supplier: Promega Corporation

LY 294002 is a potent and specific cell-permeable inhibitor of phosphatidylinositol 3-kinases (PI 3-kinases).

Supplier: Adipogen

Dihydrofluorescein diacetate is a fluorescent probe for detecting intracellular oxidants. It is hydrolyzed by cellular esterases to dihydrofluorescein and is then oxidized to fluorescein primarily by H2O2. Dihydrofluorescein diacetate might be reactive toward a broad range of oxidizing reactions that may be increased during intracellular oxidant stress. Cell-loading studies indicate that dihydrofluorescein achieves higher intracellular concentrations than the other redox sensors such as Dihydrorhodamine 123 (Ex/Em: 490/514nm).

Supplier: Adipogen

Because of its relatively constant and well-known fluorescence quantum yield, quinine is also used in photochemistry as a common fluorescence standard. It has been used for imaging of oxygen evolution and oxide formation. Chloride and bromide have been shown to quench fluorescence. Generally it is famous as potassium channel blocker with antipyretic (fever-reducing), antimalarial, analgesic (painkilling), and anti-inflammatory properties.

Supplier: DWK Life Sciences (KIMBLE)

Polypropylene replacement caps for connecting adapters.

Supplier: Adipogen

Aromatic terminal alkynes. Building block for synthesis. The terminal alkyne functionality has a wide range of applications.

Supplier: Adipogen

A-Type proanthocyanidine. Selective cytotoxic agent. Potent antioxidant. Lipid peroxidation inhibitor. Antidiabetic, with similar effects to insulin activity in adipogenesis. Free radical scavenger. Antithrombotic. Inhibits platelet aggregation. Apoptosis inhibitor. Reduces intracellular Ca(2+) overload and ROS production. Antibacterial. Cyclooxygenase-2 (COX-2) inhibitor in vitro. LDL oxidation inhibitor.

Supplier: MilliporeSigma

A stable, water-soluble nitric oxide (NO) donor (¹/₂=27 hours) with properties similar to those of Glyco-SNAP-1 (80051-924). Dissolve in aqueous buffer immediately after use.

Supplier: Adipogen

Reagent for solid-phase sequencing.

Supplier: Adipogen

This compound is widely used as a substrate for Cytochrome P450. It has also been used as a marker substrate for assessment of Drug-Drug interactions to multiple isoforms of UDP-glucuronosyltransferases. Suitable as pH-indicator. Trifluoromethylumbelliferone is a slightly longer wavelength analog of 4-methylcoumarin (4-MU) with a pKa that more closely matches physiological pH values.

Supplier: Adipogen

Multipotent flavonoid antioxidant. Potent free radical scavenger. Neuroprotective. Anticancer compound with chemosensitizing activity. Cell cycle arrest, apoptosis and autophagy inducer. Proteasome inhibitor. Pleiotropic kinase inhibitor, including tyrosine protein kinase (Trk), mitochondrial ATPase, cAMP- and cGMP-phosphodiesterases, PI3-kinase activity, phospholipase A2 and protein kinase C (PKC). DNA topoisomerases inhibitor. SIRT1 activator. Heat shock proteins inhibitor. Reversible fatty acid synthase inhibitor. Antithrombotic, antihistaminic and anti-inflammatory agent. Monoamine oxidase inhibitor. Vasodilatory compound. anti-diabetic compound.

Supplier: Adipogen

Mycotoxin. Phytotoxic and cytotoxic agent. Immunosuppressive activity. Affects chromosome congression and spindle microtubule organization in PtK1 cells. Actin and myosin inhibitor.

Supplier: Adipogen

Florescent probe that is commonly used as a building block to synthesize coumarin-type fluorescent probes. Spectral data: lambdaex 320 nm, lambdaem 380 nm in methanol. It is used as a fluorescent label for peptides. It is widely used for developing FRET peptide substrates for analyzing protease activities and for HPLC derivatization by fluorescence detection.

Supplier: Adipogen

Potent competitive gamma-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist. Weak nicotinic acetylcholine receptor agonist. Muscle relaxant. Anti-inflammatory. Has analgesic properties. Shows strong epileptogenic and convulsant activity. Anticancer compound through inhibition of NF-kappaB and NF-kappaB-regulated gene products Apoptosis inducer. Suppressed osteoclastogenesis induced by RANKL and tumor cells via the NF-kappaB signaling pathway. Therapeutic option for the management of bone metastatic disease.

Supplier: Adipogen

Cell permeable potent inhibitor of protein kinase C. Does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase or calcium/calmodulin-dependent protein kinase. Antiplatelet, anti-inflammatory, antibacterial and antitumor compound. Apoptosis inducer in cancer cells in vitro and in vivo. Activates MAPK and JUNK signaling pathways. Affects translocation of PKC from cytosol to plasma membrane. Neurite outgrowth stimulator. Inhibits binding of BclXL to Bak (IC50 = 1.5 µM) or Bad proteins and stimulates apoptosis in several cancer cell lines. Blocks human P2X7 receptor. Induces cell cycle arrest in G1 phase. Specific cyclooxygenase-2 inhibitor.

Supplier: Adipogen

Cytotoxic hydrophobic primary bile acid. Activator of farnesoid X receptor (FXR), a nuclear receptor that is hepatoprotective and regulates bile acid synthesis (cholesterol 7alpha-hydroxylase (CYP7A1) suppression), conjugation and transport, as well as genes involved in lipid and glucose metabolism and. Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, insulin resistance, hyperlipidemia and atherosclerosis. Inhibitor of 5beta-reductase (AKR1D1). Potent selective inhibitor of DD2 (AKR1C2). Potent inhibitor of 11beta-HSD1 dehydrogenase. Changes tumor cell viability via IL-6 pathway. Anticancer compound. Apoptosis inducer. Immunosuppressive and anti-inflammatory compound. Modulates oxidative stress. Differentiation regulator of mouse embryonic stem cells. Used for dissolution of cholesterol gallstones.

Supplier: Adipogen

Potent mycotoxin. Phytotoxin. Actin polymerization inhibitor. Used in actin polymerization and cytoskeletal reorganization studies. Antibacterial, antifungal, nematocidal and antitumor compound. Apoptosis inducer. Anti-angiogenic agent. Shows immunosuppressive activity. Shown to modulate the CNS with potential anti-parkinson activity.

Supplier: Adipogen

Fluorescent probe in biology used to detect protein location and activation, identify protein complex formation and conformational changes and monitor biological processes in vitro or in vivo.

Supplier: Adipogen

Cell-permeable non-fluorescent reactive oxygen species (ROS) indicator. Passively diffuses across membranes where it is oxidized by peroxynitrite to rhodamine 123 which localizes in the mitochondria and exhibits green fluorescence (Ex/Em wavelengths of 500 and 536 nm). Used to investigate reactive oxygen intermediates produced by human and murine phagocytes, activated rat mast cells and cultured endothelial cells. In addition, it has been used together with Fura Red calcium indicator to simultaneously measure oxidative bursts and Ca2+ fluxes in monocytes and granulocytes. Dihydrorhodamine 123 has been shown to be a more sensitive probe than H2DCFDA for detecting granulocyte respiratory bursts.

Supplier: Adipogen

Building block for synthesis.

Supplier: Adipogen

Widely used fluorophore well-known for preparing fluorogenic 7-Amido-4-methylcoumarin (AMC) substrates for cystine aminopeptidase and other hydrolases. Used as reference compound in enzyme assays.

Supplier: Adipogen

Apoptosis inducer. Cell cycle arrest inducer. Anticancer compound Antioxidant. Hepatoprotective. Inhibits TGF-beta/Smad-mediated fibrogenesis. Stimulates wound healing. Anti-diabetic. Glycogen phosphorylase inhibitor. Neuroprotective. Modulates multiple targets associated with amyloid-beta precursor protein processing and amyloid-beta protein clearance. Down regulates BACE1 and increases ADAM10 maturation. Anti-hyperglycemic compound. Anti-inflammatory and antinociceptive compound. Antiangiogenic. Acetylcholinesterase (AChE) inhibitor. PPARgamma inhibitor through a C/EBPbeta-independent mechanisms. Anti-osteoporotic. Inhibits adipogenic differentiation of bone marrow stromal cells (BMSC).

Supplier: Adipogen

Sulfonephthalein dye. Acid-base pH indicator dye with pH ranges of pH 1.2 (Red) - pH 2.8 (Yellow), and pH 8.0 (Yellow) - pH 9.6 (Blue). Spectral data: Absorption, lambdamax 424nm. Has been used as pH sensor, indicator, in cosmetics and drug applications, microbiological assays and determining lipases.

Supplier: Aladdin Scientific

3-Buten-1-ol is a homoallyl alcohol that can be prepared by the dehydration of 1,4-butanediol using cerium catalyst. The intramolecular hydrogen bonding of 3-buten-1-ol has been studied using FT-IR and 1 H NMR spectroscopic data. Its microwave spectrum has been recorded and analyzed.

Supplier: Adipogen

Steroidal prohormone of the major insect molting hormone 20-hydroxyecdysone. A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. Induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes. Plays a key role in insect development, cell proliferaton, growth and apoptosis by controlling gene expression involved in moulting and metamorphosis. It acts through a heterodimeric receptor comprising the ecdysone receptor and the ultraspiracle proteins (USP). Appears in many plants mostly as a protection agent (toxins or antifeedants) against herbivorous insects. Used for controlled gene expression in scientific research, agriculture and medicine. Used for the development of selective insect growth regulators for use as environmentally benign insecticides.

Supplier: Adipogen

Mycotoxin. Chelation agent with polyfunctional skeleton for development of biologically active compounds. Moderate antibacterial agent. Tyrosinase inhibitor. Inhibits catecholase activity of tyrosinase. Anti-melanogenic. Skin whitening agent. Antioxidant. Reactive oxygen species (ROS) scavenger. D-Amino acid oxidase (DAAO) inhibitor. Shown to inhibit NF-kB activation. Inducer of macrophage activation. Radioprotectant activity. Antileishmanial agent. Insecticidal. Antifungal chemosensitizer. Used in cosmetics and as food additive.

Supplier: Aladdin Scientific

Complexation of the amino- and carboxyl-protected tripeptide with 3-amino-5-methylpyrazole was studied by low-temperature NMR experiments in a freonic solvent.application:3-Amino-5-methylpyrazole was employed as beta-sheet template to investigate its interaction with ferrocenoyl-dipeptides. It was also used in the synthesis of 4-aryl-3,7,7-trimethyl-2,4,6,7,8,9-hexahydropyrazolo[3,4-b]quinolin-5-ones.