1150 Results for: "NMR"

Supplier: Adipogen

Nitric oxide (NO) independent, superoxide-sensitive soluble guanylyl cyclase (sGC) activator. Induces concentration-dependent increase in cGMP levels. Inhibits platelet adhesion to collagen. Thombosis inhibitor. Non-specific phosphodiesterase inhibitor. Na+ channel blocker. Anticancer compound. HIF-alpha inhibitor. Blocks angiogenesis. Tumor growth inhibitor. Apoptosis inducer. NK cell differentiation enhancer. TRAIL sensitizer.

Supplier: Adipogen

Potent cell permeable and selective inhibitor of yeast NAD+-dependent histone deacetylase (HDAC) Sir2p. Displays higher activity in vivo than in vitro. Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket. Shown to have diverse effects also in mammalian cells.

Supplier: Adipogen

Potent and selective inhibitor of CDKs. More potent than olomoucine. Inhibits CDK1/cyclin B kinase (IC50 = 450 nM), CDK2 (IC50 = 700 nM) and CDK5/p35 (IC50 = 160 nM). Inhibits M phase promoting factor (MPF) kinase activity. Arrests human fibroblasts in G1 phase. Antitumor compound. Activates the mitogen-activated protein kinase pathway. Targets both the p53 and NF-kappaB pathways[10]. Has effects on calcium channel gating. Prevents DNA damage-induced cyclin A1 upregulation. Apoptosis inducer. As CYC202 in phase I clinical trials. Reviews.

Supplier: TCI America

CAS Number: 5394-63-8 MDL Number: MFCD00040468 Molecular Formula: C7H10O3 Molecular Weight: 142.15 Purity/Analysis Method: 95.0% (NMR) Form: Liquid Color: Yellow Boiling point (°C): 77 Flash Point (°C): 86 Specific Gravity (20/20): 1.08

Supplier: Adipogen

Cell permeable gamma-secretase inhibitor (IC50 = 115 nM for total beta-amyloid, IC50 = 200 nM for beta-amyloid 1-42). Reduces Abeta levels in vivo. Blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD). Does not inhibit persenilinase. Notch processing inhibitor. Enhances neuronal differentiation independent of sonic hedgehog (Shh) signaling. CDK5 activity inhibitor. Apoptosis enhancer.

Supplier: Adipogen

Derivative of Aphidicolin (BVT-0307) http://www.adipogen.com/bvt-0307/-aphidicolin.html. Mycotoxin. So far no comparison to aphidicolin's biological activity (DNA polymerase alpha antiviral and antitumor activity) has been performed.

Supplier: Adipogen

Adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 less potent than AdipoRon http://www.adipogen.com/ag-cr1-0154/adiporon.html . Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms.

Supplier: Adipogen

Activated ester of ruthenium complex for acylation of amino acid side chain amines. This label is perfectly suitable for 1D- or 2D-protein gel staining. A simple pre-electrophoresis procedure provides a sensitivity better than SYPRO Ruby and a similar dynamic range. In contrast to SYPRO Ruby, this staining exhibits a logarithmic dependency on the amount of protein.

Supplier: TCI America

[NMR Shift Reagent] CAS Number: 15522-71-1 MDL Number: MFCD00000019 Molecular Formula: C33H57EuO6 Molecular Weight: 701.78 Purity/Analysis Method: 95.0% (T) Form: Crystal Color: Pale Yellow Melting point (°C): 190

Supplier: Chem-Impex International

5-Dibenzosuberone is a versatile organic compound with applications in organic synthesis and materials science. Its unique structure makes it ideal for advanced materials and pharmaceuticals, offering stability and reactivity for innovative chemical transformations.

Supplier: Adipogen

Stable pyridinium salt of o-iodoxybenzoic acid (PIBX) is a convenient substitute of o-iodoxybenzoic acid (IBX) as an oxidant. PIBX is safer, has neutral properties behaves as an equivalent to IBX in the oxidation of alcohols to ketones or aldehydes in polar solvents and provides higher oxidation rate in THF due to better solubility.

Supplier: Adipogen

Potent CDK1/cyclin B (IC50 = 35 nM) inhibitor. Anti-tumor compound Potent inhibitor of CDK2/cyclin A, CDK2/cyclin E (IC50 = 200 nM), CDK5/p25 (IC50 = 40 nM), CDK5/p35 (IC50 = 40 nM). GSK-3beta (glycogen synthase kinase-3beta) inhibitor. Apoptosis inhibitor. Apoptosis inducer. Angiogenesis inhibitor.

Supplier: Adipogen

Cell permeable low toxicity Sonic hedgehog (Shh) agonist. Cell permeable smoothened (Smo) agonist. Potent activator of VEGF expression in vitro.

Supplier: Adipogen

Cell/membrane permeable, non-toxic, pH-sensitive fluorescent dye (blue-green range) for live imaging of pH alteration in acidic organelles, lysosomes, autophagolysosomes, vesicles, cells, tissue and even small, transparent whole animals without side effects. Useful as intracellular pH indicator with a wide range of fluorescence (pH 3 to pH 13). pH-dependent dual-emission peaks, can be used for ratiometric evaluation of pH (F400/440). No esterases are involved, therefore no toxic by-products occur. Long-term stable; is barely metabolized. Fluorescence co-localizes with LysoTracker® Red DND-99. (LysoTracker® is a registered trademark of Molecular Probes, Inc.)

Supplier: Chem-Impex International

3-Chloro-2-nitropyridine is a key intermediate in pharmaceutical and agrochemical synthesis, valued for its stability and reactivity. Ideal for researchers and industry professionals seeking efficient synthetic pathways.

Supplier: Chem-Impex International

3-(Methylthio)benzaldehyde is a key aromatic compound used in pharmaceuticals, agrochemicals, and fragrances. Its unique properties make it ideal for organic synthesis and materials science applications, providing innovative solutions for researchers and industry professionals.

Supplier: Chem-Impex International

Discover the versatile applications of 5-Methyl-2-pyrazinecarbaldehyde in flavoring, fragrance, and chemical synthesis. This aromatic aldehyde enhances culinary products and serves as a building block in pharmaceuticals, making it essential for industry professionals.

Supplier: Chem-Impex International

2,4-Thiazolidinedione is a key compound in diabetes management, enhancing insulin sensitivity and improving glucose metabolism. Explore its pharmaceutical applications and research potential in metabolic disorders. Ideal for drug development and innovative treatments.

Supplier: Chem-Impex International

3'-Fluoro-4'-hydroxyacetophenone is a versatile compound used in pharmaceuticals and organic synthesis. Its unique properties enhance drug discovery and development, making it essential for researchers and industry professionals. Explore its applications in dyes and agrochemicals for innovative solutions.

Supplier: Chem-Impex International

3-(4'-Pyridyl)-D-alanine is a key amino acid derivative used in pharmaceutical and agricultural applications. Its unique structure aids in drug development and enhances herbicide efficacy, making it essential for researchers and industry professionals.

Supplier: Adipogen

Cell permeable, highly potent inhibitor of gamma-secretase (IC50 = 0.06 nM).

Supplier: Adipogen

Selective inhibitor of Pim-1 and Pim-2 protein kinases. Inducer of G1 phase cell cycle arrest. Inducer of p27Kip1. Inducer of apoptosis through the mitochondrial pathway. Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway. Downregulates c-myc. Inhibitor of PRAS40 phosphorylation and mTOR activity. Potential anti-cancer compound. Blocks prostate cancer growth.

Supplier: Adipogen

A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd 7 nM). Weak and reversible inhibition of nNOS (neuronal nitric oxide synthase/NOS I) (Ki 2) and eNOS (endothelial nitric oxide synthase/NOS III) (Ki 50 µM). Inhibits tumor growth. Increases vasoconstriction to noradrenaline. Improves contractile function. Improves stroke outcome and decreases glutamate release. Anti-inflammatory. Review.

Supplier: Adipogen

Protein kinase C (PKC) inhibitor. Binds with reversed orientation to protein kinase A (PKA).

Supplier: Chem-Impex International

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Supplier: Adipogen

Fluorogenic substrate used to measure sensitively enzymatic neuraminidase activity in fluorometric assays in mammalian and viral sources. Neuraminidase is catalyzed by the hydrolysation to form N-acetylneuraminic acid and the blue fluorescent soluble compound 4-Methylumbelliferone, which can be detected fluorometrically. Spectral data: lambdaex 315 nm| lambdaem 374 nm (pH.7.0) or lambdaex 365 nm| lambdaem 445 nm (after cleavage by neuraminidase). Used for fluorescent staining of sialidases in PAGE.

Supplier: Chem-Impex International

3-(Hydroxymethyl)-4-isopropoxybenzaldehyde is a key intermediate in organic synthesis, valuable for pharmaceuticals and agrochemicals. Its unique structure enhances fragrance formulations, making it essential for researchers and industry professionals seeking innovative solutions.

Supplier: Adipogen

Selective N- and P/Q-type Ca2+-channel agonist. These Ca2+-channels regulate transmitter release in synapses. Potential lead compound for a variety of disorders that result in neuromuscular weakness.

Supplier: Adipogen

Potent fluorescent inhibitor of choline acetyltransferase. CMKLR1 antagonist. Inhibits chemerin-stimulated beta-arrestin2 association with CMKLR1, as well as chemerin-triggered CMKLR1+ cell migration. Aldehyde dehydrogenase 1 (ALDH1A1) antagonist.

Supplier: Chem-Impex International

3-Chloro-4-ethoxybenzaldehyde is a key aromatic aldehyde used in organic synthesis, pharmaceuticals, and agrochemicals. Its unique structure enhances reactivity, making it ideal for developing novel compounds and formulations. Explore its versatile applications in research and industry.