1150 Results for: "NMR"

Supplier: Adipogen

beta-Naphthocyclinone is an Isochromane quinone antibiotic.

Supplier: Adipogen

Necroptosis inhibitor. Indirect RIP1 kinase inhibitor. Cardioprotective

Supplier: Adipogen

Potent cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Myosin light chain kinase (MLCK) inhibitor. Tool to study protein crystal structure-inhibitor interactions.

Supplier: Adipogen

3-Hydroxy-hexanoyl-DL-homoserine lactone is a small diffusible signaling molecule and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones (AHL) are involved in quorum sensing, controlling gene expression, and cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention, and formation of biofilms.

Supplier: Chem-Impex International

N-Methylbenzylamine (CAS 103-67-3) is a versatile organic compound used in pharmaceuticals, agrochemicals, and specialty chemicals. Its unique properties make it ideal for organic synthesis, surfactants, and corrosion inhibitors, providing essential solutions for researchers and industry professionals.

Supplier: Adipogen

Tumor promoter. Protein kinase C (PKC) inducer. Mitogenesis activator. Differentiation inducer.

Supplier: Adipogen

Cell permeable and reversible kinesin-specific MKLP-2 (mitotic kinesin-like protein 2) inhibitor. Inhibits the recruitment of the chromosome passenger proteins survivin and aurora B to the central spindle during anaphase chromosome segregation. Moderate DYRK1A inhibitor (IC50= 5.5 µM). Lead compound.

Supplier: Adipogen

Sonic hedgehog (Shh) signaling pathway modulator. Cell permeable potent smoothened (Smo) antagonist. Inhibits wt and oncogenic Smo. SAG activity (Prod. Nr. AG-CR1-3506) inhibitor. Gli1 reporter gene expression inhibitor. Suppresses the Shh-dependent translocation of Smo to the primary cilium. Potential tumor growth blocker.

Supplier: Adipogen

Nuclear protein pirin inhibitor. Inhibits the interaction between Bcl3 oncoprotein and the nuclear protein pirin. Melanoma cell migration inhibitor.

Supplier: TCI America

[NMR Shift Reagent] CAS Number: 15492-48-5 MDL Number: MFCD00000027 Molecular Formula: C33H57O6Pr Molecular Weight: 690.72 Form: Crystal Color: Slightly Pale Yellow Melting point (°C): 220

Supplier: Chem-Impex International

3-Cyclopentylpropanal is a versatile aldehyde used in pharmaceuticals, agrochemicals, and flavoring agents. Its unique structure enhances reactivity, making it ideal for innovative synthetic pathways in chemical research.

Supplier: Adipogen

Potent and subtype-selective (1'000-fold) PPARgamma agonist. Angiogenesis inhibitor. Apoptosis inhibitor. Anti-inflammatory. Anti-hyperglycemic and anti-hyperlipidemic agent. Antidiabetic. The glucose-lowering effect in rats is 100-fold more potent than that of troglitazone.

Supplier: Adipogen

Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competetive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Promotes osteoblastogenesis in human mesenchymal stem cells.

Supplier: Adipogen

Enhancer of myocardial regenerative repair by stem cells. Potent inducer of Nkx2.5 and a subset of other cardiac markers, including myocardin, and sarcomeric-tropomyosin (SalphaTM) in a variety of different stem/progenitor cells.

Supplier: Adipogen

Dynamin-1, -2 (DNM1, DNM2) and Dynamin-related protein 1 (DRP1) inhibitor. Endocytosis inhibitor. Viral infection inhibitor. Destabilizes actin filaments. Inhibits entry of Trypanosoma into macrophages. Inhibitor of mitophagy. Inhibitor of hepatocyte lipophagy

Supplier: Adipogen

Phytotoxin (inhibits root growth of seeding). Specific inhibitor of eukaryotic DNA polymerase alpha and DNA synthesis (competition with dCTP).

Supplier: Adipogen

Cytotoxic and anti-inflammatory compound (weak). Antioxidant. Lipid peroxidation inhibitor. Free radical scavenger. Inhibitor of myeloperoxidase activity. Hypoglycemic. Decreases blood glucose levels in diabetic and normal rats. Insulinomimetic. Modulates glucose homeostasis. Decreases blood glucose levels and stimulates glucose uptake in muscle. Inhibits GLUT4 mediated glucose uptake in differentiated 3T3-L1 cells. Improves insulin resistance by the activation of the classical insulin transduction pathway. Increases adiponectin secretion in 3T3-L1 adipocytes. Antinoniceptive. May have antidyslipidemic activity.

Supplier: TCI America

[e.e. Determination Reagent by NMR] CAS Number: 60646-30-2 MDL Number: MFCD00062968 Molecular Formula: C16H11F3O Molecular Weight: 276.26 Purity/Analysis Method: 99.0% (GC) Form: Crystal Color: Very Pale Yellow Melting point (°C): 135 Specific rotation [a]20/D: 30.5 deg (C=1, CHCl3)

Supplier: Adipogen

Potent and selective FXR agonist (EC50= 99nM). Induces SHP in HSCs to suppress TIMP-1 expression. Apoptosis inducer. Protects against liver fibrosis development in rat in vivo. Displays anticholeretic activity in rat in vivo. Promotes preadipocyte differentiation. Regulates adipogenesis and insulin signaling in vivo. Inhibits vascular smooth muscle cell inflammation and migration.

Supplier: Adipogen

Microtubule inhibitor. Antitumor compound. Mitosis inhibitor. Arrests the cell cycle at G2/M phase. Promotes tubulin depolymerization. Induces fragmentation of the Golgi complex. Inhibits the T cell antigen receptor. Stimulates the intrinsic GTPase activity of tubulin. Activates the JNK/SAPK signaling pathway. Apoptosis inducer. Autophagy inhibition through prevention of autophagosome-lysosome fusion.

Supplier: Adipogen

Salt for the generation of cationic transition metal complexes.

Supplier: Adipogen

Potent and selective inhibitor of CDKs. More potent than olomoucine. Inhibits CDK1/cyclin B kinase (IC50 = 450 nM), CDK2 (IC50 = 700 nM) and CDK5/p35 (IC50 = 160 nM). Inhibits M phase promoting factor (MPF) kinase activity. Arrests human fibroblasts in G1 phase. Antitumor compound. Activates the mitogen-activated protein kinase pathway. Targets both the p53 and NF-kappaB pathways[10]. Has effects on calcium channel gating. Prevents DNA damage-induced cyclin A1 upregulation. Apoptosis inducer. As CYC202 in phase I clinical trials. Reviews.

Supplier: Chem-Impex International

4-Toluoylacetonitrile is a key compound in organic synthesis and pharmaceutical research, valued for its reactivity and stability. Ideal for producing specialty chemicals and intermediates, it streamlines synthesis pathways and enhances yields, making it essential for researchers and industry professionals.

Supplier: Adipogen

Cell permeable highly active Sonic hedgehog (Shh) agonist. Cell permeable smoothened (Smo) agonist.

Supplier: Chem-Impex International

3'-Benzyloxyacetophenone is a key organic compound used in pharmaceuticals and fine chemicals. Its unique structure allows for versatile applications in drug synthesis and photochemical processes, making it essential for researchers and industry professionals.

Supplier: Adipogen

Derivative of Aphidicolin (BVT-0307) http://www.adipogen.com/bvt-0307/-aphidicolin.html. Mycotoxin. So far no comparison to aphidicolin's biological activity (DNA polymerase alpha antiviral and antitumor activity) has been performed.

Supplier: Adipogen

Potent and selective cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor. Apoptosis inducer. Potent glycogen synthase kinase (GSK-3alpha/beta) inhibitor.

Supplier: Chem-Impex International

Diethylglycine is a valuable amino acid derivative used in pharmaceutical research and drug formulation. Its unique properties enhance solubility and bioavailability, making it essential for innovative therapeutic applications. Ideal for researchers in drug development and biochemistry, it supports metabolic studies and enzyme assessments with a favorable safety profile.

Supplier: Adipogen

Potent CDK1/cyclin B (IC50 = 9.5 nM) and CDK2/cyclin A3 (IC50 = 5.4 nM) inhibitor. 1'000-fold more potent than NU2058. Selective for CDK1 and CDK2 compared to CDK4/D1 (IC50 = 1.6 µM), DYRK1A (IC50 = 0.9 µM), PDK1 (IC50 = 0.8 µM) and ROCK-II (IC50 = 0.6 µM). Inhibits cell growth.

Supplier: Chem-Impex International

Trichlorovinylsilane is a key silane compound used in the synthesis of silicone polymers, coatings, and adhesives. Its unique reactivity enhances adhesion and durability, making it essential for advanced materials in various industries. Explore its applications and benefits for improved product performance.