1149 Results for: "NMR"

Supplier: Adipogen

Fluorescent reagent with high selectivity.

Supplier: Adipogen

Eremophilane sesquiterpene. Nontoxic secondary metabolite from Penicillium roqueforti.

Supplier: Adipogen

Highly sensitive and selective fluorogenic H2S probe. The aromatic azide moiety of AzMC is selectively reduced in the presence of H2S, producing the fluorescent 7-amino-4-methylcoumarin (AMC) with a concomitant increase in fluorescence with lambdaex = 365 nm and lambdaem = 450 nm. Photoaffinity labeling probe for the substrate binding site of human sulfotransferase 1A1 (SULT1A1). Probe to monitor the enzymatic production of H2S in vitro and to visualize H2S in living cells. Tool for monitoring the activity of pyridoxal-5'-phosphate (PLP)-dependent enzymes (e.g. cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CGL) and tryptophan synthase (TS)). Tool to identify novel cystathionine beta-synthase (CBS) inhibitors and activators. Suitable for high-throughput screening. Caution: Use of this product with DTT, TCEP and/or biological thiols at concentrations of 25 mM should be avoided for maximum efficiency.

Supplier: Thermo Scientific Chemicals

MDL: MFCD00044637

Supplier: Thermo Scientific Chemicals

MDL: MFCD00044635 Notes: Minimum isotopic purity 99.96%

Supplier: Adipogen

Anticancer compound. Shown to inhibit progression of prostate cancer cells. Anti-obesity agent. 3T3-L1 adipocyte differentiation and FAS expression inhibitor.

Supplier: Adipogen

Polarity fluorescent probe.

Supplier: Adipogen

Cytochalasan mycotoxin, derivative of chaetoglobosin A . Phytotoxic. Cytotoxic against HCT116 (human colon cancer cells). Antibacterial (Ps. aeruginosa). Anti-inflammatory and immunomodulatory compound.

Supplier: Adipogen

Mycotoxin. Derivative of sterigmatocystin. Carcinogenic activity. Anticancer compound. Cytotoxic and genotoxic.

Supplier: Adipogen

Reference compound for the fluorescent (nitric oxide) NO probe DAR-4.

Supplier: Adipogen

Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low µm concentration. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice.

Supplier: Adipogen

Photo-stable fluorescent probe for the detection of nitric oxide (NO).

Supplier: Thermo Scientific Chemicals

MDL: MFCD00044239

Supplier: Adipogen

Indole alkaloid. Monoamine oxidase inhibitor (MAOI). Antiepileptic (anticonvulsant) compound. Inhibitor of platelet aggregation and thromboxane A2 synthesis. Weak antifungal and antituberculosis activity. Useful as lead structure for potent antifungal substances.

Supplier: Adipogen

Anticancer colchicine analog. Microtubule polymerization inhibitor. Prevents cell division.

Supplier: Adipogen

Cell permeable, potent and selective cyclin-dependent kinase CDK-1 (CDC2), -2 and -5 inhibitor. Apoptosis inducer. Antitumor agent. Inhibits cell cycle progression at the G1/S and G2/M transitions. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Important probe for understanding the cellular roles of CDKs. Inhibitor of alpha-glucosidases. Maturation inhibitor of sheep oocytes.

Supplier: Adipogen

Specific histone acetyltransferase Gcn5 inhibitor. Anticancer compound. Pre-mRNA splicing inhibitor. Blocks splicing before the first catalytic steps. Potential anti-inflammatory compound.

Supplier: Adipogen

Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII. Anti-inflammatory. Anti-gastric ulcer. Mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) inhibitor. Apoptosis inducer in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy. Anxiolytic. Antidepressant-like activity. Hepatoprotective effects. CYP2C19 and CYP3A4 inhibitor. Neuroprotective. Antileishmanial activity. cPLA2 and sPLA2 inhibitor.

Supplier: Adipogen

Bombesin receptor subtype-3 (BRS-3) agonist. Energy homeostasis regulator.

Supplier: Adipogen

Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane permeable Smoothened (Smo) antagonist. Acts on extra- and intracellular exposed Smo. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.

Supplier: Adipogen

Eremophilane sesquiterpene. Nontoxic secondary metabolite from Penicillium roqueforti.

Supplier: Adipogen

Potent inhibitor of DYRKs and CLKs. Interacts also with GSK-3alpha/beta, CK2 and PIM1. Interacts with the complex PIKfyve/Vac14/Fig4. Modulates alternative splicing of pre-mRNA in various cellular systems. Neuroprotective against APP-induced cell death. Tools to study and modulate pre-RNA splicing. Potential compound for Alzheimer's disease and diseases involving abnormal pre-mRNA splicing. Potential compound to study Down syndrome (inhibition of DYRK1A). Neuroprotective against glutamate-induced cell death. Autophagy activator.

Supplier: Mettler Toledo

Electrode is a part of INGOLD tradition, there is no pH application for which there is not an optimal technical solution.

Supplier: Adipogen

Some cationic mitochondrial dyes such as 4-Di-1-ASP and 4-Di-2-ASP stain presynaptic nerve terminals independent of neuronal activity. The photostable 4-Di-2-ASP dye, which is nontoxic to cells, has been employed to stain living nerve terminals in rabbit corneal epithelium, in rat epidermis and at mouse, snake and frog neuromuscular junctions, as well as to visualize the innervation of the human choroid and whole mounts of the gastrointestinal tract. Methods for using 4-Di-2-ASP to image neuronal cells in live animals have been described (Ex/Em = 488/607 nm).

Supplier: Adipogen

Fluorescent probe for detection of H2S2 and hydrogen polysulfides in aqueous buffers.

Supplier: Adipogen

Antioxidant. Free radical scavenger. Nitric oxide (NO) scavenger. Anticancer compound. Antiproliferative. Apoptosis inducer. Reduces induced DNA damage. Protective against carcinogenesis. Hypolipidaemic. Reduces triacylglycerol levels. Anti-inflammatory. Platelet aggregation inhibitor. Anti-hyperglycaemic. Anti-adipogenic. Insulin-mimetic. Activates synthesis of glucose transporter GLUT4. Neuroprotective. Cardioprotective. Reduces lipid peroxidation. Weak alpha-glucosidase inhibitor. Vasodilatory compound.

Supplier: Thermo Scientific Chemicals

MDL: MFCD00044639 Beilstein Registry No.: 114377

Supplier: Thermo Scientific Chemicals

Deuterium oxide 100.0 atom % D, AcroSeal™ for NMR spectroscopy

Supplier: Thermo Scientific Chemicals

Deuterium chloride 20% (w/w) in D₂O 99.5 atom % D for NMR spectroscopy

Supplier: Adipogen

Mild amine-group derivatizing reagent. Non-acidic by-product prevents decomposition and reduces GC column degradation.