62290 Results for: "Msynth Plus Pharma Synthesis"

Supplier: G-Biosciences

Adenosine deaminase inhibitor; Anticancer agent.

Supplier: G-Biosciences

A broad-spectrum tetracycline antibiotic1. Inhibits matrix metalloproteases2. Promotes wound repair by inhibiting collagen degradation in rat models3. Displays neuroprotective effects in neurodegenerative diseases4. Frequently used in doxycycline-controlled transcriptional activation systems for regulation of gene expression in cell culture and organisms5,6.

Supplier: G-Biosciences

A broad-spectrum tetracycline antibiotic1. Inhibits matrix metalloproteases2. Promotes wound repair by inhibiting collagen degradation in rat models3. Displays neuroprotective effects in neurodegenerative diseases4. Frequently used in doxycycline-controlled transcriptional activation systems for regulation of gene expression in cell culture and organisms5,6.

Supplier: G-Biosciences

Water-soluble and orally active analog of camptothecin, a DNA topoisomerase I inhibitor1. Inhibits topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells, IC50s=13 and 2 nM respectively2. Downregulates B-Myb and MycN expression in neuroblastoma cells3. A clinically useful anticancer agent.

Supplier: G-Biosciences

Potent and highly selective inhibitor of the mammalian target of rapamycin kinase (mTOR), IC50 = 0.8 nM1,2. mTOR acts as a nutrient/energy/redox sensor and controller of protein synthesis3, making AZD8055 a useful tool in cancer research4. AZD8055 induced mitochondrial dysfunction and stress response in primary human Treg cells5.

Supplier: G-Biosciences

Aphidicolin specifically inhibits DNA polymerase α and δ via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases1. Arrests cell cycle at early S phase while allowing continued cell growth2. Potentiates apoptosis induction induced by other agents3. Increases gene amplification frequency in HeLa S3 cells overexpressing Bcl-2.

Supplier: G-Biosciences

An adenosine analog lacking the hydroxyl at the 3’ position. Inhibits PARP1 and polyadenylation2. Displays anti-inflammatory effects1,3 and neuroprotective effects by inhibiting Aβ-induced apoptosis in hippocampal neurons4. Induces apoptosis in a variety of cancer cell lines5. Displays antiobesity effects.6 Inhibits cell senescence via activation of AMPK.7 Maintains stem cell pluripotency and increases iPS cell generation efficiency.

Supplier: G-Biosciences

ERGi-USU selectively inhibits the growth of ERG-positive VCaP prostate cancer cells, COLO320 colon cancer cells, KG-1 and MOLT-4 leukemia cells with minimal effect on ERG-negative cells or normal prostate or endothelial cells (IC50=169 nM for cell growth and 315 nM for ERG protein in VCaP cells). It selectively inhibits the kinase RIOK2 (Kd=200 nM) causing disruption of ribosomal biogenesis and ribosomal stress.

Supplier: G-Biosciences

Inhibitor of dihydroorotate dehydrogenase (DHODH)1,2 with IC50’s between 0.2 and 5.8 µM in various cell lines3 and 20 nM for isolated enzyme4. Reduced leukemic cell burden, decreased levels of leukemia-initiating cells, and improved survival in human and mouse models of acute myeloid leukemia.4 Displays broad antiviral activity against flaviviruses, positive-strand RNA alphaviruses, negative-strand RNA rhabdoviruses, Influenza A and B viruses, and HIV.

Supplier: G-Biosciences

Favipiravir is an inhibitor of Influenza viruses A, B, and C (IC50s: A = 0.03-0.20 µg/mL H1N1, 0.01-0.30 H2N2, 0.08-0.48 H3N2, 0.14-0.15 H4N2, 0.24-1.60 H7N2, 0.20-0.82 H5N1, 0.35 H1N2; B = 0.04-0.09 µg/mL; C = 0.03-0.06 µg/mL) as well as strains resistant to adamantane-type antivirals, oseltamivir, and zanamivir1-3. It displayed no cytotoxicity in a variety of cells. Favipiravir selectively inhibits viral RNA-dependent RNA polymerase4. Favipiravir has also shown activity against other viruses including arena, phlebo, hanta, flavi, entero, alpha, respiratory syncytial, and noroviruses5. In clinical trials for treatment of SARS-CoV-26,7.