162 Results for: "MilliporeSigma TLC"

Supplier: MilliporeSigma

(SDS; sodium dodecyl sulfate; sodium lauryl sulfate). White solid. An ionic detergent useful in electrophoretic separation of proteins and lipids. Purity: >99% by TLC. Soluble in H2O. Aggregation number 62, CMC 7-10 mM, micellar weight 18,000.

Supplier: MilliporeSigma

Sialyl Lewis x, Sodium Salt,Enzymatically prepared tetrasaccharide which acts as a minimal binding ligand for E-selectins.

Supplier: MilliporeSigma

Irreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. Effective concentration: 50µM.

Supplier: MilliporeSigma

A natural dietary compound reported to have anticarcinogenic and anti-inflammatory properties. A selective, non-competitive inhibitor of 5-lipoxygenase (ID50=3.7µM). Inhibits Ca2+-induced LDL oxidation in the initiation phase but acts as a prooxidant in the propagation phase. An irreversible inhibitor of glutathione S-transferases and a non-competitive inhibitor of xanthine oxidase.

Supplier: MilliporeSigma

Inhibitor of calpain I (Ki=190nM), calpain II (Ki=220nM), cathepsin B (Ki=150nM) and cathepsin L (Ki=0.5nM). Inhibits neutral cysteine proteases and the proteasome (Ki=6µM). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Also inhibits retrovirus-induced apoptosis in L929 cells. Inhibits the proteolysis of I[kappa]B-[alpha] and I[kappa]B-[beta] by the ubiquitin-proteasome complex. Inhibits cell cycle progression at G1/S and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.

Supplier: MilliporeSigma

JC-1, a cationic, fluorescent, carbocyanine dye that can be used as a ratiometric indicator of mitochondrial potential δΨm in cells, tissues, and isolated mitochondria.

Supplier: MilliporeSigma

NADPH-diaphorase substrate that competitively inhibits nitric oxide synthase (IC50=3–4µM). A well-known scavenger of superoxide anions. Useful as a substrate for alkaline phosphatase, often in conjunction with BCIP.

Supplier: MilliporeSigma

White solid. Primary bile acid. Purity: >96% by TLC. Soluble in AcOH and EtOH. RTECS FZ9600000, CAS 361-09-1, M.W. 430.6.

Supplier: MilliporeSigma

A phenolic product found in both grape skin and wines. Has antifungal, antitumor and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED50=15µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED50=3.7µM). Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED50=27µM) and acts as an anti-mutagenic agent (ED50=15µM) in TM677 cells treated with DMBA. Also a selective inhibitor of P450 1A1.

Supplier: MilliporeSigma

White solid. PROTECT FROM MOISTURE. Highly purified and intended for use as a detergent to solubilize membrane-bound proteins in their native state. Purity: >99% by TLC. Soluble in H2O. Absorbance (10%, H2O, 290 nm): <0.25. pKa 6.2.

Supplier: MilliporeSigma

An ionic detergent for the solubilization of membrane-bound proteins.

Supplier: MilliporeSigma

A cell-permeable tumor-promoting sesquiterpene lactone that releases Ca2+ by inhibiting endoplasmic reticular Ca2+-ATPase (IC50=4–13nM)