49513 Results for: "Lasers and Light Sources&amp"

Supplier: ESI Source

PEPSEP SPRAYER 2- F/THERMO SCIENTIFIC

Supplier: Waldmann Lighting

LED CLAMP-ON LED CLAMP-ON 35 IN REACH

Supplier: Waldmann Lighting

CONVERTOR MAGNIFIER LED 35IN REACH

Supplier: LGC Standards

TRC Paraffin Wax

Supplier: Proteintech

NFkB is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFkB is activated by various intra- and extracellular stimuli such as cytokines, oxidant free radicals, ultraviolet irradiation, and bacterial or viral products. NFkB is a family of transcription factors that consists of homo- and heterodimers of NFkB1/p50 and RelA/p65 subunits, and controls a variety of cellular events including development and immune responses. All members share a conserved amino terminus domain that includes dimerization, nuclear localization, and DNA binding regions, and a carboxy terminal transactivation domain. Serines 529 and 536 in the transactivation domain of RelA/p65 are phosphorylated in response to several stimuli including phorbol ester, IL1 alpha and TNF alpha as mediated by IkB kinase and p38 MAPK. Phosphorylation of serines 529 and 536 is critical for RelA/p65 transcriptional activity. Activated NFkB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFkB has been associated with a number of inflammatory diseases while persistent inhibition of NFkB leads to inappropriate immune cell development or delayed cell growth. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. This antibody can bind both p105 and p50 isoforms of NFKB1.

Supplier: LEONARD LIGHT INDUSTRIES (PTY)

CUPEL BLOCK 10 PLACE 50/CS

Supplier: ESI Source

MAGRESYN STREPTAVIDIN ULTRA-CAPACITY 5ML

Supplier: ESI Source

MAGRESYN SAX-MICROPARTICLE MAGNETIC 5ML

Supplier: ESI Source

MAGRESYN TRYPSIN ULTRA-CAPACITY HIGH PER

Supplier: ESI Source

COLUMN AURORA ELITE 15CMX75UM ID PK5

Supplier: ESI Source

COLUMN ANALYTICL ULTRA/EXTREME 25CMX75UM

Supplier: ESI Source

SERIES PEPSEP C18 4CMX150UM W/1.9UM

Supplier: ESI Source

CABLE HIGH VOLTAGE 50CM

Supplier: ESI Source

COLUMN AURORA ELITE 15CMX75UM ID 1.7UM

Supplier: ESI Source

COLUMN C18 RAPID AURORA 5CMX150UM/ID

Supplier: ESI Source

NANOCOLUMN XT C18 COMPATBL W EASY SPRAY

Supplier: ESI Source

SLEEVE HIGH PRESSURE 1/16IN 10MM PK10

Supplier: ESI Source

COLUMN ANALTIC PEPSEPC18 25CMX75UM 1.9UM

Supplier: ESI Source

MAGRESYN STREPTAVIDIN MAGNETIC MICR 10ML

Supplier: Proteintech

NFkB is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFkB is activated by various intra- and extracellular stimuli such as cytokines, oxidant free radicals, ultraviolet irradiation, and bacterial or viral products. NFkB is a family of transcription factors that consists of homo- and heterodimers of NFkB1/p50 and RelA/p65 subunits, and controls a variety of cellular events including development and immune responses. All members share a conserved amino terminus domain that includes dimerization, nuclear localization, and DNA binding regions, and a carboxy terminal transactivation domain. Serines 529 and 536 in the transactivation domain of RelA/p65 are phosphorylated in response to several stimuli including phorbol ester, IL1 alpha and TNF alpha as mediated by IkB kinase and p38 MAPK. Phosphorylation of serines 529 and 536 is critical for RelA/p65 transcriptional activity. Activated NFkB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFkB has been associated with a number of inflammatory diseases while persistent inhibition of NFkB leads to inappropriate immune cell development or delayed cell growth. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. This antibody can bind p105 isoforms of NFKB1.

Supplier: MP Biomedicals

Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate has been reported to arrest the cell cycle in late G1/S thus leading to the inhibition of the synthesis of DNA, RNA, thymidylates, and proteins. The main mechanism of action is reported to involve the inhibition of enzymes involved in purine metabolism which leads to the accumulation of adenosine or the suppression of intercellular adhesion molecule expression by T cells. Additionally, this compound has been observed to inhibit DHFR.
Methotrexate is used for chemotherapy either alone or in combination with other agents. It is effective for the treatment of a number of cancers including: breast, head and neck, leukemia, lymphoma, lung, osteosarcoma, bladder, and trophoblastic neoplasms. It is also used in treatment of autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It is used to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.
Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Methotrexate is an allosteric inhibititor of dihydrofolate reductase (DHFR), the enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. Since tetrahydrolfolate is required for purine and pyrimidine synthesis, methotrexate treatment results in the inhibition of DNA and RNA synthesis.

Supplier: ESI Source

COLUMN REPROSIL-PUR 120 C18-AQ 3UM

Supplier: ESI Source

COLUMN UHPLC PACKED 1.7UM C18 25CMX75UM

Supplier: TOTAL SOURCE MANUFACTURING

SHOE COVER PP BL SKID FREE SOLE XL CS300

Supplier: ESI Source

MAGRESYN STREPTAVIDIN MAGNTC MICROPARTIC

Supplier: ESI Source

REAGENT STREPTAVIDIN MAGRESYN MS 2ML

Supplier: ESI Source

LOTUS TIP W/HYDROPHOBIC COATING PK6

Supplier: ESI Source

EMITTER FUSED SILICA/STEEL 10UM/ID

Supplier: ESI Source

FERRULE PEEK NUT 365UM 1/64IN PK10

Supplier: ESI Source

COLUMN ULTIMATE 1.7UM C18 25CMX75UM PK5