2209 Results for: "Immunology"

Duvelisib (1201438-56-3) is a potent and selective (IC50’s: PI3Kα=1602 nM, PI3Kβ=85 nM, PI3Kδ= 2.5 nM, PI3Kγ=27 nM) dual PI3Kδ/γ inhibitor.1 It inhibits B and T cell proliferation, blocks neutrophil migration, and inhibits basophil activation. Duvelisib antagonizes B-cell receptor crosslinking activated pro-survival signals in primary chronic lymphocytic leukemia cells.2 Duvelisib also shows preclinical/clinical activity against other hematologic malignancies such as Non-Hodgkins lymphoma, T-cell lymphoma, ande others.3,4 Useful clinical agent for the treatment of various blood cancers. Low-dose treatment of T-cell-inflamed tumor models of head and neck cancers with Duvelisib enhanced responses to PD-L1 blockade via suppression of myeloid-derived suppressor cells.5 Higher doses reversed the effect due to suppression of tumor-infiltrating T lymphocytes.

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Green Fluorescent Protein (GFP) Control Protein

Supplier: Rockland Immunochemical

Green Fluorescent Protein (GFP) Control Protein

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Mouse Exodus-2 / CCL21

Supplier: Rockland Immunochemical

Recombinant Mouse Exodus-2 / CCL21 control protein

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Human Recombinant Follistatin (from E. coli)

Supplier: Rockland Immunochemical

Recombinant Human Follistatin control protein

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Human Recombinant Myostatin

Supplier: Rockland Immunochemical

Recombinant Human Myostatin control protein

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Human Recombinant RANTES

Supplier: Rockland Immunochemical

rHuman RANTES (CCL5) control protein

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MAPK1 Blocking Peptide

Supplier: Rockland Immunochemical

ERK2 Internal Blocking Control Peptide

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AZD7762 >98% Checkpoint kinase 1/2 inhibitor

Supplier: G-Biosciences

Potent and selective inhibitor of checkpoint kinases 1 and 2 (IC50 = 5 nM for both).1 It abrogates DNA damage-induced S and G2 checkpoints and enhances the efficacy of DNA damaging agents such as gemcitabine and irinotecan. AZD7762 also enhanced the radiation sensitivity of p53-mutant tumor cell lines.2,3 AZD7762 was able to overcome imatinib resistance in CML cells.4 AZD7762 has also been reported to be a potent inhibitor of MEKK2 (MAP3K2) – IC50 = 20 nM.5 It has also recently been shown to inhibit antigen-stimulated degranulation from RBL-2H3 (IC50 = 28 nM) and BMMCs (IC50 = 99 nM) as well as suppressing degranulation of LAD2 human mast cells (IC50 = 50 nM) via Syk suppression through inactivation of Lyn and Fyn kinases.6 Enhances CRISPR-Cpf1-mediated precise genome editing.

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Rat INF gamma

Supplier: Rockland Immunochemical

Recombinant Rat INF gamma control protein

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Mouse Recombinant IL-2

Supplier: Rockland Immunochemical

Recombinant Mouse IL-2 control protein

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Mouse Sonic Hedgehog

Supplier: Rockland Immunochemical

Recombinant Mouse Sonic Hedgehog control protein

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3,3',5,5'-Tetramethylbenzidine (TMB) solution, standard sensitivity ready-to-use, precipitating

Supplier: Thermo Scientific Chemicals

Excellent colorimetric substrate for detection of horseradish peroxidase labelled probes and is used with peroxidase and peroxidase coupled systems, particularly in ELISA techniques, blue result

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PUMPMATIC® Disposable Serological Pipettes, Polystyrene, Ashton Pumpmatic

Supplier: Ashton Pumpmatic

PUMPMATIC® Disposable Serological Dispensing/Transfer Pipettes are available in sterile or nonsterile formats, with a variety of sizes and quantities to choose from.