2209 Results for: "Immunology"

Supplier: AFG Bioscience

Bovine monocyte Chemotactic Protein 1/monocyte Chemotactic and Activating Factor, (MCP-1/CCL2/MCAF) ELISA Kit, AFG Bioscience

Supplier: Thermo Scientific Chemicals

Blocking reagent for immunohistochemistry experiments.

Supplier: AFG Bioscience

Human Interleukin-12 Receptor Subunit ß-1 (IL-12Rß1/IL-12R/IL-12Rß) ELISA Kit, AFG Bioscience

Supplier: G-Biosciences

Tranilast is an anti-allergy agent (inhibition of mast cell degranulation) that has been shown to have potent immunomodulatory effects (via inhibition of endotoxin induced: PGE2, IC50 = 1 to 20 µM; TXB2, IC50 = 10 to 50 µM; TGFβ1, IC50 = 100 to 200 µM; IL-8, IC50 = 100 µM). Tranilast also displays anti-angiogenic properties.

Supplier: G-Biosciences

Aprepitant is a potent human neurokinin-1 (NK-1) antagonist.1 It is an FDA approved medication for the treatment of chemotherapy-induced and postoperative nausea and vomiting.2 Aprepitant is also a selective activator of the K2P channel TRAAK.3 It also has been shown to have multiple anticancer effects.

Supplier: G-Biosciences

LFM-A13 is a selective inhibitor of Bruton’s tyrosine kinase (BTK) – IC50’s = 2.5 µM (recombinant BTK) and 17.2 µM (human BTK).1,2 It has also been shown to inhibit Polo-ilke kinase (PLK) – IC50 = 61 µM for human PLK3.3 It displayed no activity (concentrations up to 278 µM) at JAK1, JAK3, HCK, EGFRK and IRK2 or CDK1-3, CHK1, IKK, MAPK1, SAPK2a and ten tyrosine kinases3.

Supplier: G-Biosciences

NLG919 (1402836-58-1) is a potent IDO-pathway inhibitor (Ki = 7 nM; EC50 = 75 nM).1 It synergizes with chemo-radiation therapy to promote T cell dependent complement deposition in a murine model of glioblastoma.2 In combination with paclitaxel in a mouse B16-F10 melanoma model, NLG919 increased the percentage of CD3+, CD8+, and CD4+ T cells and secretion of IFN-γ and interleukin-2 while decreasing the percentage of CD4+CD25+ regulatory T cells.

Supplier: Thermo Scientific Chemicals

For the hybridization of probes to nucleic acids in Nothern and Southern blotting.

Supplier: Rockland Immunochemical

1X Tris buffered saline (TBS) pH 7.8

Supplier: G-Biosciences

Indoximod is a modulator of indoleamine 2,3-dioxygenase (IDO) activity.1 IDO can be used by tumors to avoid elimination by the host immune response2,3, thus inhibition of IDO is an interesting cancer therapeutic option. Indoximod is not a direct inhibitor of IDO, but instead targets the IDO gene leading to downstream effects.3 IDO-mediated catabolism of tryptophan inhibits the immunoregulatory kinases mTOR and PKC5. This is relieved by Indoximod acting as a potent tryptophan mimetic restoring mTOR and PKC signaling.

Supplier: G-Biosciences

Thalidomide analog which, like thalidomide,1 binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity2. Induces degradation of T-cell repressors Ikaros (IKZF1) and Aiolos (IKZF3) leading to T cell activation2. Selective inhibition of IKZF1 and IKZF3 in multiple myeloma cells results in cell death3,4. Cell permeable. Caution: Teratogenic.

Supplier: MP Biomedicals

Soluble in normal saline solution (25 mg/mL, 0.9%NaCl).

Supplier: Thermo Scientific Chemicals

Saponin permeating solution, is used as a cell permeabilizing agent.

Supplier: Thermo Scientific Chemicals

A high-osmolality radiocontrast agent

Supplier: Enzo Life Sciences

Selective agonist of TLR1/TLR2 complex

Supplier: G-Biosciences

JAK3 inhibitor. Inhibits human glioblastoma cell adhesion and invasion.1 Increases survival in a mouse ALS model.2 Delays or prevents autoimmune type 1 diabetes in NOD mice.3 Exhibits potent anti-inflammatory activity in mouse models of peritonitis, colitis, cellulitis and systemic inflammatory response syndrome.4 Displays protective effects against myocardial ischemia and reperfusion injury in mouse models.

Supplier: G-Biosciences

A cationized form of BSA that is taken into antigen presenting cells quicker and more efficiently that other carrier proteins, generating a quicker and greater immune response.

Supplier: G-Biosciences

FK-506 induces immunosuppression by inhibiting T cell proliferation. Inhibits FKBP12 and calcineurin (IC50 ~1 nM). Cell permeable.

Supplier: G-Biosciences

Analog of FK-506. Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Displays antiinflammatory effects in skin diseases3. Cell permeable and active in vivo.

Supplier: G-Biosciences

Improves obesity-related metabolic dysfunction in mouse models1. Increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity. Inhibits TANK-binding kinase 1 (TBK1) and IKKε (IC50=1.2 µM)2. Clinically useful in the treatment of aphthus ulcers3. Inhibits prostate tumor metastasis by targeting IKKε/TBK1/NFκB signaling.

Supplier: G-Biosciences

A indoloquinazoline alkaloid found in various plant species and possessing intriguing pharmacological activities.1 Suppresses activation of BV2 microglia cells following LPS treatment and reduces production of proinflammatory cytokines via Nrf2, HO-1 and NFκB signaling.2 Displays antiinflammatory activity targeting IL-17.3 Inhibits indoleamine 2,3-dioxygenase 2 (IDO2) with an IC50 of 5-17 μM.4 Induces growth inhibition and neuronal differentiation in human neuroblastoma LA-N-1 cells.

Supplier: Rockland Immunochemical

Lyophilized Non-Sterile Serum

Supplier: G-Biosciences

Antifibrotic agent. Prevents lung fibrosis in bleomycin-induced animal models.1 Down-regulates bleomycin-induced overexpression of lung procollagen I and III genes.2 Up-regulates RGS2 (Regulator of G-protein Signaling 2) which represents a new mechanism of pirfenidone action.3 Inhibits fibroblast proliferation.4 Suppresses TNFα production at the translational level.5 Scavenges hydroxyl radicals and inhibits lipid peroxidation in a dose-dependent manner.6 Recently approved therapeutic agent for idiopathic pulmonary fibrosis.7 Orally active.

Supplier: G-Biosciences

NLRP3 inflammasome inhibitor which likely acts via interfering with the formation of the NLRP3 inflammasome complex and which exhibits promising in vivo protective activities in mouse acute myocardial infarction models. It blocks ASC aggregation, blocks the release of IL-1β and the activation of caspase-1 in macrophages expressing constitutively active NLRP3 but does not directly inhibit caspase-1.1,2 Limits infarct size after myocardial ischemia-reperfusion as well as leukocyte infiltration in a peritonitis model in mice.

Supplier: G-Biosciences

GPR142 is highly expressed in the pancreas and immune system and shares 33% homology with GPR1391. Endogenous agonists identified to date include aromatic amino acids such as tryptophan and phenylalanine2. CLP-3094 was identified as a potent and selective GPR142 antagonist with an IC50=2.3 µM against 1 mM L-tryptophan. It inhibited insulin secretion from islets induced by L-tryptophan and other agonists and displayed anti-inflammatory activity in a mouse arthritis model.

Supplier: G-Biosciences

A fungal metabolite with immunosuppressive properties: blocks phagocytosis, cytokine production and proliferation of T and B cells1. Inhibits chymotrypsin-like activity of 20S proteasome preventing IκBα degradation and preventing NF-κB degradation2. Displays antiinflammatory activity3 and blocks leukotriene B4 production via inhibition of LTA4 hydrolase4. Inhibits nuclear NOTCH2 and recovers a tumor-suppressor NOTCH3 activity in chronic lymphocytic leukemia cells5.

Supplier: G-Biosciences

A potent and irreversible proteasome inhibitor.1 Synthetic analog of the microbial product epoxomcin.2 Compared to bortezomib it displays equal potency but greater selectivity for the chymotrypsin-like activity of the proteasome. In cell culture it is more cytotoxic than bortezomib and hematologic tumor cells exhibit greater sensitivity than solid tumor cells. Treatment of cells with carfilzomib results in the accumulation of proteasome substrates and induction of cell cycle arrest and/or apoptosis.3 Effective against multiple myeloma.4 Active in vivo.

Supplier: G-Biosciences

A potent immunosuppressive and anti-inflammatory agent. Irreversibly inhibits eukaryotic transcription via covalent binding to XPB, a subunit of the transcription factor TFIIH1. Blocks transactivation of NFκB2. Exhibits potent antiproliferative activity in 60 cancer cell lines (average IC50 = 12 nM) and synergizes with other anticancer agents3. Inhibits the inflammatory response and remarkably decreases production of TNF-α, IL-1β and IL-6 in a rat model of rheumatoid arthritis4. A fast acting RNA polymerase II inhibitor5.

Supplier: G-Biosciences

Highly selective and potent (avg. pIC50 = 6.8 versus recombinant TBK1) inhibitor of Tank-binding Kinase-1 (TBK1) with higher affinity for unactivated TBK1. It inhibited phosphorylation of IRF3 (pIC50 = 6.0), inhibited the release of IFNa from human PBMC’s (pIC50 = 6.1), and inhibited IFNb secretion from THP-1 cells (pIC50 = 5.8 dsDNA virus, 6.3 cGAMP stilmulated cells).

Supplier: G-Biosciences

Selective inhibitor of IκB kinase 2 (IKK2) (IC50 = 17.9 nM).1 Inhibits production of pro-inflammatory cytokines in arthritis and other animal models of inflammation.1,2 Also attenuates NLRP3 inflammasome activation in THP-1 myeloid cells, and suppresses IL1β-induced proliferation, migration, and invasion of HeLa cells.3,4 Continuous exposure to TPCA-1 promotes expansion of hematopoietic stem/progenitor cells (HSPCs) via improved glycolysis and limited ROS production.