2209 Results for: "Immunology"

Supplier: AFG Bioscience

Human X-linked Interleukin-1 Receptor Accessory Protein-like 2 (IL-1RAPL2) ELISA Kit, AFG Bioscience

Supplier: AFG Bioscience

Mouse Myeloperoxidase-AntiNeutrophil Cytoplasmic Antibody IgG (MPO-ANCA IgG) ELISA Kit, AFG Bioscience

Supplier: AFG Bioscience

Rat High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha (FCER1A) ELISA, AFG Bioscience

Supplier: AFG Bioscience

Human Interleukin-10 Receptor Subunit ß (IL-10Rß) ELISA Kit, AFG Bioscience

Supplier: Avantor

Safe and Colorful Activity

Supplier: G-Biosciences

H-151 is an inhibitor of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduced systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.

Supplier: G-Biosciences

Tryptophan catabolite1. Endogenous tumor-promoting ligand of the human aryl hydrocarbon receptor (AhR). Constitutively generated by human tumor cells via the action of the tryptophan degrading enzyme, tryptophan-2,3-dioxygenase (TDO). Kynurenine suppresses antitumor immune responses and promotes tumor cell survival and motility2.

Supplier: G-Biosciences

Ribavirin is a clinically useful antiviral medication for Hepatitis C, viral hemorrhagic fevers and other RNA and DNA viruses. The exact mechanism of its antiviral activity is uncertain. Various proposals include inhibition of viral polymerase1, RNA mutagenesis2, and inosine monophosphate dehydrogenase (IMPDH) inhibition.

Supplier: G-Biosciences

Inhibits Src, Bcr/Abl and Lyn tyrosine kinases (IC50= 0.55, 3.0 and 8.5 nM respectively)1,2. Suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells3.

Supplier: G-Biosciences

Galunisertib is a TGF-β kinase (TGFBR1, ALK5) inhibitor (IC50 = 56 nM)1. Blocks TGF-β-mediated SMAD2 activation and hematopoietic suppression in primary hematopoietic stem cells2. Clinically useful anticancer agent3, and is a promising co-treatment with immune checkpoint inhibitors4,5.

Supplier: Thermo Scientific Chemicals

Blocking reagent for immunohistochemistry experiments.

Supplier: Enzo Life Sciences

TPA/PMA inhibitor

Supplier: G-Biosciences

THI was identified as a biologically active impurity in caramel food coloring.1 It is a potent inhibitor of sphingosine-1-phosphate (S1P) lyase.2 It disrupts lymphocyte egress from lymphoid tissue by interfering with S1P gradients.3,4 The novel immunomodulatory activity of THI and its biochemical mechanism may represent a new target for the development of new generation of immunosuppressants.

Supplier: G-Biosciences

Toll-like receptor 7 (TLR7) agonist.1 A potent immunostimulant with a relatively broad spectrum of immunobiological activities including upregulation of the activity of B cells, T cells, NK cells, macrophages and LAK cells.2 Induces secretion of IFN- by NK cells.3 Inhibits influenza A infection in chickens.4 Induces tumor regression by reversing Treg-induced immunosuppression.

Supplier: G-Biosciences

A natural steroid from Commiphora mukul extract (guggulipid) which lowers cholesterol and acts as an FXR antagonist.1 Attenuates astrocyte-mediated neuroinflam-mation.2 Induces differentiation of pluripotent stem cells to dopaminergic neurons.3 Produces antidepressant-like effects via activation of the BDNF signaling pathway in mouse models.

Supplier: G-Biosciences

2',3'-cGAMP (CAS 1441190-66-4) is an endogenous STING (stimulator of interferon genes) agonist.1 Produced from ATP and GTP via the action of cGMP-AMP synthase (cGAS) which acts as a cytosolic DNA sensor.2,3 Induces autophagy which is a mechanism for clearance of DNA and viruses in the cytosol.4 DNA damage stimulates 2’,3’-cGAMP which stimulates an inflammatory response.

Supplier: G-Biosciences

Potent (EC50 = 1.3 nM) and selective Leukotriene D4 antagonist(LTD4)1 displaying inverse agonist activity2, Blocks binding of LTD4 to human (Ki = 0.22 nM) and guinea pig (Ki = 2.1 nM) lung membranes. Selective for the CysLT1 receptor. Multidrug resistance protein 1 (MRP1) inhibitor.

Supplier: G-Biosciences

A fungal metabolite with novel structure. Displays potent neuritogenic activity in PC12 cells. Induces multipolar and branching neurites comparable to that produced by β-NGF.1 Displays immunosuppressive activity via inhibition of immunoglobulin E production in vitro.2 Displays antiproliferative effects on four glioma cell lines by regulating tumor metabolic enzymes.3 Inhibits osteoclastogenesis and prevents ovariectomized-induced bone loss by suppression of ROS.

Supplier: G-Biosciences

A pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug)1. Displays immunomodulatory activity inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH)2. Although the molecule directly responsible for DHODH is actually A77 1726, a metabolite of Leflunomide. Rescues mice from acetaminophen-induced liver injury.

Supplier: Rockland Immunochemical

MIP-3ß Human Recombinant control protein

Supplier: G-Biosciences

An L-type calcium channel blocker.1 Prevents age-induced learning deficits in a rat model.2 Facilitates recovery of function after brain damage3 and displays neuroprotective effects4. Promotes remyelination in a mouse model of multiple sclerosis.5 In clinical use for reduction of cerebral vasospasm following subarachnoid hemorrhage.

Supplier: G-Biosciences

MDL29,951 is a new, highly specific, small molecule activator of GPR171 that has been shown to be active in intact cells1. The ability to specifically activate GPR17 allows for the study of the exact role GPR17 plays in the maturation of oligodendrocytes and may lead to a therapeutic strategy to promote myelin repair. Antagonist for the strychnine-insensitive glycine binding site of the nMDA receptor (IC50=170 nM).

Supplier: G-Biosciences

Potent and selective inhibitor of Src family kinases Lck and Src, IC50=2 and 6 nM respectively1,2. Also inhibits SIK, IC50=10, 22 and 60 nM for SIK 1, 2 and 3 respectively3. May be used along with PD-325901 and CHIR-99021 to support self-renewal of naïve human embryonic stem cells4.

Supplier: QUALITY BIOLOGICAL, INC.

PBS (phosphate buffered saline) is a balanced salt solution used for a variety biological and cell culture applications, such as washing cells before dissociation, transporting cells or tissue, diluting cells for counting, and preparing reagents.

Supplier: G-Biosciences

Antioxidant and free radical scavenger. Increases cellular levels of glutathione (GSH) and prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells1. Carnosic acid-stimulation of GSH inhibits adipocyte differentiation2. Induces apoptosis3 and inhibits the proliferation and migration of various tumor cell lines4.

Supplier: G-Biosciences

R-59022 is a diacylglycerol kinase (DAGK) inhibitor, nonselective for DAGK isotypes (IC50=2.8 µM in intact platelets)1. Induces autophagy and apoptosis in NG108-15 neuronal cells via an mTOR-independent mechanism2. Prevents conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes3. Blocks filovirus internalization in host cells.

Supplier: G-Biosciences

Pan-specific inhibitor of phosphodiesterases (IC50=2 to 50 µM). Inhibition of PDEs leads to increased concentration of intracellular cAMP which activates PKA2. Does not inhibit PDE8 or PDE93. Weak adenosine receptor antagonist.

Supplier: Thermo Scientific Chemicals

A histochemical substrate for alkaline phosphatase

Supplier: G-Biosciences

Centrally acting M1 muscarinic acetylcholine receptor antagonist (Ki=0.59 nM, rat).1 Also inhibits the dopamine transporter (Ki=160 nM).2 Enhances remyelination and significantly decreases clinical severity in the experimental autoimmune encephalomyelitis model of relapsing-remitting multiple sclerosis alone or in combination with immunosuppressive agents.3 Inhibits hepatitis C virus infection.

Supplier: AFG Bioscience

Bovine monocyte Chemotactic Protein 1/monocyte Chemotactic and Activating Factor, (MCP-1/CCL2/MCAF) ELISA Kit, AFG Bioscience