2209 Results for: "Immunology"

Supplier: AFG Bioscience

Rat Monocyte Chemotactic Protein 2 (MCP-2) ELISA Kit=CCL8, AFG Bioscience

Supplier: AFG Bioscience

Mouse Anti-Smooth Muscle Antibody (ASMA) ELISA Kit, AFG Bioscience

Supplier: G-Biosciences

Purine antimetabolite drug used to treat acute lymphocytic leukemia, Crohn’s disease, ulcerative colitis, and inflammatory bowel disease.1 It inhibits DNA synthesis by inhibiting the production of purine containing nucleotides. The immunomodulatory activity of 6-Mercaptopurine is mainly the result of the 6-MP metabolite 6-thioguanine triphosphate (6-TGTP) binding to small GTPase Rac.

Supplier: G-Biosciences

Immunomodulator1. Blocks the biosynthesis of guanine nucleotides via inhibition of inosine 5’-monophosphate dehydrogenase which suppresses the production of proinflammatory cytokines, nitric oxide and LDH in macrophages2,3. Inhibits IL-2 -dependent T cell proliferation.

Supplier: G-Biosciences

Inhibits (IC50=18 nM) formation of the PD-1/PD-L1 complex via binding to PD-L1 and inducing dimerization.

Supplier: AFG Bioscience

Bovine Interferon-induced GTP-Binding Protein Mx2 (MX2) ELISA Kit, AFG Bioscience

Supplier: AFG Bioscience

Human Interleukin-13 Receptor Subunit α-1 (IL-13Rα1) ELISA Kit, AFG Bioscience

Supplier: AFG Bioscience

Human Soluble Cluster of Differentiation 40 ligand (sCD40L) ELISA Kit, AFG Bioscience

Supplier: AFG Bioscience

Human Interleukin-1 Receptor Accessory Protein (IL-1RAP) ELISA Kit, AFG Bioscience

Supplier: AFG Bioscience

Human Interleukin-18 Binding Prorein (IL-18BP) ELISA Kit, AFG Bioscience

Supplier: AFG Bioscience

Human Interleukin-12 Subunit α (IL-12α) ELISA Kit, AFG Bioscience

Supplier: AFG Bioscience

Human Interleukin-36 Receptor Antagonist Protein (IL1F5) ELISA Kit, AFG Bioscience

Supplier: AFG Bioscience

Human Interleukin-18 Receptor Accessory Protein (IL-18RAP) ELISA Kit, AFG Bioscience

Supplier: G-Biosciences

Pioglitazone is a clinically useful antidiabetic drug. It is a selective agonist of the human peroxisome proliferator-activated receptor γ1(PPARγ1; EC50 = 490 nM2, 550 nM3) with weak agonist activity at PPARα and no activity at PPARδ.

Supplier: G-Biosciences

Toll-like receptor 7 (TLR7) agonist (EC50=290 nM in a HEK293 cell line reporter assay; IFNα MEC 3 nM, 100 fold selectivity over TNFα activation).1 Displays significant antiviral activity via immune activation against HIV2,3, Hepatitis B4,5, Norovirus6, and enterovirus.

Supplier: AFG Bioscience

Human Interleukin-22 Receptor Subunit α-2 (IL-22Rα2) ELISA Kit, AFG Bioscience

Supplier: AFG Bioscience

Rat Leukocyte Immunoglobulin -like Receptor Subfamily A Member 5 (LILRA5) ELISA, AFG Bioscience

Supplier: AFG Bioscience

Rat High Affinity Immunoglobulin Epsilon Receptor Subunit Gamma (FCER1G) ELISA, AFG Bioscience

Supplier: AFG Bioscience

Human Interleukin-17A (IL-17A, IL-17) ELISA Kit, AFG Bioscience

Supplier: Thermo Scientific Chemicals

Isomaltotriose, 97%. Powder.

Supplier: G-Biosciences

Potent and selective inhibitor of TAK1 (a mitogen activated protein kinase kinase kinase) IC50=8 nM1. Selective over MEKK1 and MEKK4. Blocks IL-1-induced activation of TAK1 in cell culture1. Blocks the production of pro-inflammatory cytokines and displays anti-inflammatory activity in various models.

Supplier: G-Biosciences

Potent Apoptosis signal-regulating kinase 1 (ASK1) inhibitor (pIC50 = 8.3)1 found to improve metabolic parameters in nonalcoholic steatohepatitis, reduce hepatic steatosis, inflammation, and fibrosis2-4. Selonsertib suppressed the efflux function of multidrug resistance (MDR) transporters ABCB1 and ABCG2.

Supplier: G-Biosciences

Semisynthetic analog of rapamycin with potent immunosuppressive activity1. Inhibits mTOR2. Clinically useful immunosuppressant3.

Supplier: G-Biosciences

Displays anti-inflammatory activity. Regulates immune cell function and autoimmune response by inhibition of IL-12 signalling and cytokine production1. Protects pancreatic beta cells and prevents type I diabetes in non-obese diabetic mice2. Reduces LPS-induced TNF alpha levels in CD-1 mice3. Cell permeable.

Supplier: G-Biosciences

Prostaglandin E2 (PGE2) is an endogenous prostaglandin derived from the action of cyclooxygenase on arachidonic acid. PGE2 has diverse biological actions in the areas of inflammation, cancer, immune modulation, fertility, smooth muscle relaxation and hematopoietic stem cell homeostasis. PGE2 acts through four distinct receptors: EP1, EP2, EP3, EP4.

Supplier: AFG Bioscience

Human Interleukin-22 Receptor Subunit α-1 (IL-22Rα1) ELISA Kit, AFG Bioscience

Supplier: AFG Bioscience

Human Interleukin-28 Receptor Subunit α (IL-28Rα) ELISA Kit, AFG Bioscience

Supplier: AFG Bioscience

Human Interleukin-31 Receptor Subunit α (IL-31Rα) ELISA Kit, AFG Bioscience

Supplier: AFG Bioscience

Human Interleukin-12 Receptor Subunit ß-2 (IL-12Rß2) ELISA Kit, AFG Bioscience

Supplier: AFG Bioscience

Human Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) ELISA Kit, AFG Bioscience