57476 Results for: "High-Throughput-Screening"

Supplier: Aladdin Scientific

Cyclobutane-1,2,3,4-tetracarboxylic dianhydride was used to synthesize polyimide films and poly(amic acid) having liquid crystal alignment layers. Reactant for: ?

Supplier: MEDCHEMEXPRESS LLC MS

Designed to impress, these utensils elevate dining experiences with superior strength and style, while reducing costs and time-consuming cleanup.

Supplier: Aladdin Scientific

Butyric acid is a fatty acid isolated from many dairy products that exhibits anticancer activity. Butyric acid inhibits histone deacetylases (HDACs) and induces apoptosis and G1 phase cell cycle arrest in glioma cells.

Supplier: Aladdin Scientific

Hexagonal boron nitride (hBN) has a layered structure similar to graphite and can be exfoliated as singlelayered BN sheets. hBN has applications in catalysts, optoelectronics and semiconductor devices.

Supplier: Aladdin Scientific

Hexagonal boron nitride (hBN) has a layered structure similar to graphite and can be exfoliated as singlelayered BN sheets. hBN has applications in catalysts, optoelectronics and semiconductor devices.

Supplier: United Scientific Supplies

A multifunctional digital scale with removable bowl.

Supplier: Aladdin Scientific

Cerium(III) chloride heptahydrate is a hygroscopic crystalline solid. It is soluble in water and forms acidic solutions. It is used as a cerium source in various applications such as nanometal oxide synthesis and catalysis.

Supplier: Aladdin Scientific

Beryllium fluoride (BeF2) has a variety of applications across different fields. In the study of thermodynamic analysis of batteries, it is used to determine the energy density. In protein crystallography, it is used as a substitute for phosphate and in conjunction with ADP to inhibit protein action and crystallize proteins in the bound state.

Supplier: Aladdin Scientific

Cerium(III) chloride heptahydrate is a hygroscopic crystalline solid. It is soluble in water and forms acidic solutions. It is used as a cerium source in various applications such as nanometal oxide synthesis and catalysis.

Supplier: Berkshire

MicroPolx® 1900 is a knitted polyester/nylon microfiber sealed edge cleanroom wiper.

Supplier: FUJIFILM IRVINE SCIENTIFIC WAKO CHE

Y-27632 is reagent for cell culture applications, including human ES/iPS cell culture. It enhances cell viability and reduces cell death during passaging and cryopreservation.

Supplier: FUJIFILM IRVINE SCIENTIFIC WAKO CHE

Y-27632 is reagent for cell culture applications, including human ES/iPS cell culture. It enhances cell viability and reduces cell death during passaging and cryopreservation.

Supplier: Aladdin Scientific

Ammonium tungstate, also called ammonium paratungstate or APT is a white crystalline salt with a chemical formula either written (NH₄)10H₂(W₂O₇)6 or (NH₄)10(H₂W₁₂O₄₂). APT is extracted from tungsten ores and is the critical raw material for the production of tungsten metal. Additionally, it is employed in the manufacturing of catalysts, pigments, and specialty chemicals. Its applications extend to the electronics industry, where it is utilized in the production of electronic components and semiconductor materials due to its excellent thermal and electrical properties.

Supplier: Aladdin Scientific

CHIR-99021 (CT99021) HCl is hydrochloride of CHIR-99021, which is aGSK-3α/βinhibitor withIC50of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of theWnt/beta-cateninsignaling pathway. CHIR-99021 significantly rescues light-inducedautophagyand augments GR, RORα and autophagy-related proteins.TargetsGSK-3β (Cell-free assay); GSK-3α (Cell-free assay) 6.7 nM; 10 nM In vitro CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. Furthermore, CHIR-99021 shows only weak binding to a panel of 22 pharmacologically relevant receptors and little inhibitory activity against a panel of 23 nonkinase enzymes. CHIR-99021 induces the activation of glycogen synthase (GS) in insulin receptor-expressing CHO-IR cells with EC50 of 0.763 μM. In addition to simulating the actions of insulin, inhibition of GSK-3 by CHIR-99021 (3 μM) increases free cytosolic β-catenin by 1.9-fold, mimicking the canonical Wnt signaling pathway in 3T3-L1 preadipocytes. During any of the first 3 days of differentiation, CHIR-99021 treatment inhibits the preadipocyte differentiation with IC50 of 0.3 μM by blocking induction of CCAAT/enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ).

Supplier: Aladdin Scientific

CHIR-99021 (CT99021) HCl is hydrochloride of CHIR-99021, which is aGSK-3α/βinhibitor withIC50of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of theWnt/beta-cateninsignaling pathway. CHIR-99021 significantly rescues light-inducedautophagyand augments GR, RORα and autophagy-related proteins.TargetsGSK-3β (Cell-free assay); GSK-3α (Cell-free assay) 6.7 nM; 10 nM In vitro CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. Furthermore, CHIR-99021 shows only weak binding to a panel of 22 pharmacologically relevant receptors and little inhibitory activity against a panel of 23 nonkinase enzymes. CHIR-99021 induces the activation of glycogen synthase (GS) in insulin receptor-expressing CHO-IR cells with EC50 of 0.763 μM. In addition to simulating the actions of insulin, inhibition of GSK-3 by CHIR-99021 (3 μM) increases free cytosolic β-catenin by 1.9-fold, mimicking the canonical Wnt signaling pathway in 3T3-L1 preadipocytes. During any of the first 3 days of differentiation, CHIR-99021 treatment inhibits the preadipocyte differentiation with IC50 of 0.3 μM by blocking induction of CCAAT/enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ).

Supplier: Aladdin Scientific

BAPTA/AM [1,2-Bis(2-aminophenoxy)ethane-N, N, N′, N′-tetraacetic acid tetrakis(acetoxymethyl ester)] is a non-fluorescent, membrane-permeable form of BAPTA. Whereas the BAPTA, Free acid is not cell permeable and is only useful for manipulating extracellular Ca2+ levels, BAPTA/AM can be used with a wide variety of cells, where it is hydrolyzed by cytosolic esterases and trapped intracellularly. Experiments have shown that BAPTA/AM abolishes vitamin D3-induced increase in intracellular Ca2+, and may induce inactivation of protein kinase C.

Supplier: Aladdin Scientific

BAPTA/AM [1,2-Bis(2-aminophenoxy)ethane-N, N, N′, N′-tetraacetic acid tetrakis(acetoxymethyl ester)] is a non-fluorescent, membrane-permeable form of BAPTA. Whereas the BAPTA, Free acid is not cell permeable and is only useful for manipulating extracellular Ca2+ levels, BAPTA/AM can be used with a wide variety of cells, where it is hydrolyzed by cytosolic esterases and trapped intracellularly. Experiments have shown that BAPTA/AM abolishes vitamin D3-induced increase in intracellular Ca2+, and may induce inactivation of protein kinase C.

Supplier: Aladdin Scientific

Bisphenol A (BPA) is a diphenylmethane derivative, commonly used in the production of polycarbonate plastics, epoxy resins, and various other plastic-based consumer products. It is also known to exhibit strong endocrine-disrupting ability.

Supplier: WORLD PRECISION INSTRUMENTS LLC

The properties of this bio-compatible surgical adhesive make it exceptionally useful for neuroscience applications, peripheral nerve studies and similar biomedical applications. These  silicone elastomers also eliminate the mess and time involved in pre-mixing other commonly used formulations (such as Wacker SilGel^®and Sylgard^®). Each silicone elastomer is packaged in a double barrel syringe and is automatically mixed when pressed out of the mixer tip provided.

Supplier: Aladdin Scientific

Almorexant HCl (ACT-078573) is an orally active, dualorexin receptorantagonist withIC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3. TargetsOX2 receptor ; OX1 receptor 3.4 nM; 6.6 nMIn vitroAlmorexant inhibits the increase in intracellular Ca2+ induced by 10 nM human orexin-A in Chinese hamster ovary cells with IC50 of 16 nM (rat) and 13 nM (human) for the OX1 receptor and 15 nM (rat) and 8 nM (human) for the OX2 receptor.

Supplier: Aladdin Scientific

Almorexant HCl (ACT-078573) is an orally active, dualorexin receptorantagonist withIC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3. TargetsOX2 receptor ; OX1 receptor 3.4 nM; 6.6 nMIn vitroAlmorexant inhibits the increase in intracellular Ca2+ induced by 10 nM human orexin-A in Chinese hamster ovary cells with IC50 of 16 nM (rat) and 13 nM (human) for the OX1 receptor and 15 nM (rat) and 8 nM (human) for the OX2 receptor.

Supplier: Aladdin Scientific

AZD9496 is an oralestrogen receptorinhibitor that blocks the growth of ER-positive and ESR1 mutant breast tumours in preclinical models.Targetsestrogen receptorin vitroAZD9496 showed pmol/L equipotent binding to both ERα and ERβ isoforms. AZD9496 directly targets ERα for downregulation in vitro. And it also antagonizes and downregulates mutant ER in vitro and in vivo.

Supplier: Aladdin Scientific

AM 095 AM095 is an antagonist of the LPA type 1 receptor with IC50 values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively. TargetsLPA1 receptorIn vitroAM095 is a potent LPA1 receptor antagonist because it inhibited GTPγS binding to Chinese hamster ovary (CHO) cell membranes overexpressing recombinant human or mouse LPA1 with IC50 values of 0.98 and 0.73 μM, respectively, and exhibited no LPA1 agonism. In functional assays, AM095 inhibited LPA-driven chemotaxis of CHO cells overexpressing mouse LPA1 (IC50=778 nM) and human A2058 melanoma cells (IC50=233 nM).

Supplier: Aladdin Scientific

AZD8835 ia a novel mixed inhibitor ofPI3 KαandPI3 Kδwith IC50 of 6.2 nM and 5.7 nM, respectively, also with selectivity againstPI3 Kβ(IC50=431 nM) andPI3 Kγ(IC50=90 nM). TargetsPI3 Kδ (Cell-based assay); PI3 Kα (Cell-free assay); PI3 Kγ (Cell-based assay); PI3 Kβ (Cell-based assay) 5.7 nM; 6.2 nM; 90 nM; 431 nMIn vitroAZD8835 is a potent inhibitor of PI3 Kα (wild type, E545 K and H1047 R mutations) and PI3 Kδ with excellent selectivity vs. PI3 Kβ, PI3 Kγ and an excellent general kinase selectivity.

Supplier: Aladdin Scientific

ABX-1431 ABX-1431 is a highly potent, selective, and CNS-penetrant Monoacylglycerol lipase (MGLL) inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively.TargetshMGLL ; mMGLL 14 nM; 27 nMIn vitroABX-1431 is a potent human MGLL inhibitor (average IC50 = 0.014 μM) with >100-fold selectivity against ABHD6 and >200-fold selectivity against PLA2G7. Treatment of intact human PC3 cells with ABX-1431 following a 30 min inhibitor incubation time causes concentration dependent inhibition of MGLL activity with an IC50 value of 0.0022 μM, which is ∼6-fold more potent than that observed In vitro.

Supplier: Aladdin Scientific

ABX-1431 ABX-1431 is a highly potent, selective, and CNS-penetrant Monoacylglycerol lipase (MGLL) inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively.TargetshMGLL ; mMGLL 14 nM; 27 nMIn vitroABX-1431 is a potent human MGLL inhibitor (average IC50 = 0.014 μM) with >100-fold selectivity against ABHD6 and >200-fold selectivity against PLA2G7. Treatment of intact human PC3 cells with ABX-1431 following a 30 min inhibitor incubation time causes concentration dependent inhibition of MGLL activity with an IC50 value of 0.0022 μM, which is ∼6-fold more potent than that observed In vitro.