42 Results for: "Epigenetics Reagents"

Supplier: ARBOR ASSAYS MS

The Histone Demethylase Fluorescent Activity Kit from Arbor Assays enables rapid detection of formaldehyde, a byproduct of histone demethylation by LSD1- and Jumonji-type HDMs. The assay measures fluorescence generated upon formaldehyde reaction with a specialized detection reagent, allowing real-time quantification of HDM activity. With a detection range of 3.125 to 200 µM, this versatile kit accommodates in vitro assays and cell lysates and is adaptable for studying HDM inhibitors, cofactor dependencies, and epigenetic modulation. Its simple 30-minute workflow after demethylation makes it ideal for high-throughput screening or detailed kinetic characterization of histone demethylase activity.

Supplier: Rockland Immunochemical

Until recently, 5-methylcytosine (5-mC) was the only known modification of DNA for epigenetic regulation. In 2009, however, a second methylated cytosine, 5-hydroxymethylcytosine (5-hmC) was discovered. This new modified base (also called the Sixth base) is generated by enzymatic conversion of 5-mC into 5-hmC by the TET family of oxygenases. Recent results indicate that 5-hmC plays important roles distinct from 5-mC. Although its precise role has still to be shown, early evidence suggests that 5-hmC may well represent a new pathway to demethylate DNA involving a repair mechanism converting 5-hmC to cytosine. This pathway could involve further oxidation of the hydroxymethyl group to a formyl or carboxyl group followed by either deformylation or decarboxylation. The carboxyl and formyl groups of 5-Formylcytosine (5-fC) and 5-Carboxylcytosine (5-caC) could be enzymatically removed without excision of the base. Due to their structural similarity, the different modified cytosine analogues are difficult to discriminate. The development of highly specific affinity-based reagents, such as antibodies, appears to be the most powerful way to differentially and specifically enrich 5-mC and 5-hmC sequences. Anti-5caC Antibody is ideal for research in Genetics and Epigenetics.

Supplier: Abcam

DNA methylation is a covalent modification of the cytosine ring at the 5' position of a CpG dinucleotide which leads to epigenetic inactivation of genes when found in 5'-CpG-3'dinucleotides within promoters or in the first exon of genes.

Supplier: Abcam

DNA methylation is a covalent modification of the cytosine ring at the 5' position of a CpG dinucleotide which leads to epigenetic inactivation of genes when found in 5'-CpG-3'dinucleotides within promoters or in the first exon of genes.

Supplier: TCI America

White crystals

Supplier: TCI America

CAS Number: 51-05-8 MDL Number: MFCD00013000 Molecular Formula: C13H20N2O2 Molecular Weight: 272.77 Purity/Analysis Method: 98.0% (HPLC,T) Form: Crystal Melting point (°C): 156

Supplier: TCI America

CAS Number: 156-54-7 MDL Number: MFCD00002816 Molecular Formula: C4H8O2 Molecular Weight: 110.09 Purity/Analysis Method: 98.0% (T) Form: Crystal Color: White Melting point (°C): 253

Supplier: TCI America

CAS Number: 304-20-1 MDL Number: MFCD00135998 Molecular Formula: C8H8N4 Molecular Weight: 196.64 Purity/Analysis Method: 99.0% (HPLC,T) Form: Crystal Melting point (°C): 273

Supplier: TCI America

CAS Number: 58880-19-6 MDL Number: MFCD03848392 Molecular Formula: C17H22N2O3 Molecular Weight: 302.37 Purity/Analysis Method: 98.0% (HPLC) Form: Crystal Color: White Melting point (°C): 144 Specific rotation [a]20/D: 136 deg (C=0.3, MeOH) Storage Temperature: 0°C

Supplier: TCI America

CAS Number: 1596-84-5 MDL Number: MFCD00002787 Molecular Formula: C6H12N2O3 Molecular Weight: 160.17 Purity/Analysis Method: 98.0% (GC,T) Form: Crystal Melting point (°C): 155

Supplier: TCI America

CAS Number: 99-66-1 MDL Number: MFCD00002672 Molecular Formula: C8H16O2 Molecular Weight: 144.21 Purity/Analysis Method: 99.0% (GC,T) Form: Clear Liquid Boiling point (°C): 220 Flash Point (°C): 126 Specific Gravity (20/20): 0.91

Supplier: TCI America

CAS Number: 331-39-5 MDL Number: MFCD00004392 Molecular Formula: C9H8O4 Molecular Weight: 180.16 Purity/Analysis Method: 98.0% (T) Form: Crystal

Supplier: STILLA TECHNOLOGIES, INC.

Assay-specific crystal flex probes and primers for the detection of GSTP1 methylation and its positive control. The GSTP1 methylation Crystal Digital PCR® assay is a 10X assay designed to detect and quantify methylation of the GSTP1 promoter using the ruby chip. The GSTP1 promoter is implicated on the GSTP1 epigenetic silencing and dysregulation of detoxification pathways contributing to tumor initiation, progression, and drug resistance.

Supplier: TCI America

CAS Number: 1316652-41-1 Molecular Formula: C16H14N4O2S Molecular Weight: 326.37 Purity/Analysis Method: 96.0% (HPLC) Form: Crystal Melting point (°C): 153 Storage Temperature: 0-10°C

Supplier: TCI America

CAS Number: 320-67-2 MDL Number: MFCD00006539 Molecular Formula: C8H12N4O5 Molecular Weight: 244.21 Purity/Analysis Method: 98.0% (T) Form: Crystal Melting point (°C): 216 Storage Temperature: 0°C

Supplier: TCI America

CAS Number: 112522-64-2 MDL Number: MFCD00866266 Molecular Formula: C15H15N3O2 Molecular Weight: 269.30 Purity/Analysis Method: 98.0% (HPLC) Form: Crystal Melting point (°C): 242 Storage Temperature: 0-10°C

Supplier: TCI America

CAS Number: 446-72-0 MDL Number: MFCD00016952 Molecular Formula: C15H10O5 Molecular Weight: 270.24 Purity/Analysis Method: 98.0% (HPLC) Form: Crystal Lambda max.: 262 nm (MeOH)Storage Temperature: 0-10°C

Supplier: TCI America

CAS Number: 149647-78-9 MDL Number: MFCD00945317 Molecular Formula: C14H20N2O3 Molecular Weight: 264.33 Purity/Analysis Method: 98.0% (HPLC,N) Form: Crystal Melting point (°C): 155 Storage Temperature: -20°C

Supplier: TCI America

CAS Number: 1239468-48-4 Molecular Formula: C15H30N2O4 Molecular Weight: 302.42 Purity/Analysis Method: 97.0% (GC) Form: Crystal Storage Temperature: 0-10°C

Supplier: TCI America

CAS Number: 251456-60-7 MDL Number: MFCD03453554 Molecular Formula: C16H25N3O3 Molecular Weight: 307.39 Purity/Analysis Method: 97.0% (HPLC) Form: Crystal Melting point (°C): 152 Storage Temperature: 0-10°C

Supplier: TCI America

CAS Number: 3690-10-6 MDL Number: MFCD04973699 Molecular Formula: C9H12N2O5 Molecular Weight: 228.20 Purity/Analysis Method: 98.0% (HPLC,T) Form: Crystal Color: White Melting point (°C): 158 Specific rotation [a]20/D: 158 deg (C=1, MeOH) Storage Temperature: 0-10°C

Supplier: TCI America

CAS Number: 1069-66-5 MDL Number: MFCD00078604 Molecular Formula: C8H16O2 Molecular Weight: 166.20 Purity/Analysis Method: 98.0% (T) Form: Crystal Color: White

Supplier: TCI America

CAS Number: 48208-26-0 MDL Number: MFCD08705332 Molecular Formula: C19H14N2O4 Molecular Weight: 334.33 Purity/Analysis Method: 98.0% (HPLC,T) Form: Crystal Color: Pale Yellow Melting point (°C): 181 Specific rotation [a]20/D: -271 deg (C=1, EtOH) Storage Temperature: 0°C

Supplier: Invitrogen

Endoproteinase Lys-C protease is a highly purified native endoproteinase validated for maximum activity and stability in proteomic applications.

Supplier: TCI America

CAS Number: 327-97-9
MDL Number: MFCD00003862
Molecular Formula: C16H18O9
Molecular Weight: 354.31
Purity/Analysis Method: >98.0% (HPLC,T)
Form: Crystal
Melting point (°C): 208
Specific rotation [a]20/D: -37 deg (C=1, H2O)

Supplier: TCI America

CAS Number: 849061-97-8 MDL Number: MFCD00006828 Molecular Formula: C15H10O7 Molecular Weight: 302.24 Purity/Analysis Method: 95.0% (HPLC,E) Form: Crystal

Supplier: TCI America

CAS Number: 2140-61-6 MDL Number: MFCD00006548 Molecular Formula: C10H15N3O5 Molecular Weight: 257.25 Purity/Analysis Method: 98.0% (HPLC,T) Form: Crystal Melting point (°C): 211 Specific rotation [a]20/D: 15 deg (C=2, H2O)

Supplier: TCI America

CAS Number: 989-51-5
MDL Number: MFCD00075940
Molecular Formula: C22H18O11
Molecular Weight: 458.38
Purity/Analysis Method: >98.0% (HPLC)
Form: Crystal
Melting point (°C): 212
Specific rotation [a]20/D: -176 deg (C=1, EtOH)

Supplier: TCI America

CAS Number: 487-52-5 MDL Number: MFCD00017300 Molecular Formula: C15H12O5 Molecular Weight: 272.26 Purity/Analysis Method: 98.0% (HPLC) Form: Crystal Melting point (°C): 215 Storage Temperature: 0°C

Supplier: IBI Scientific

Cost-effective and non-invasive method to capture saliva samples for DNA extraction.