19221 Results for: "AP+physics"

Supplier: 3M Healthcare

3M™ Water Filtration Products High Flow Series (-S) model filter system provide Recipe Quality Water™ for commercial ice machines and commercial steam tables by reducing the effects of sediment*, chlorine taste and odor and scale* while helping you protect your equipment.

Supplier: DuPont

Tychem® 10000 exhibits excellent chemical barrier properties and offers an extremely durable fabric that is puncture- and tear-resistant.

Supplier: Thermo Scientific Chemicals

Powder

Supplier: Thermo Scientific Chemicals

MDL: MFCD00150035 Beilstein Registry No.: 6121732 Notes: Suitable for Karl Fischer reagent standardization. Soluble in water

Supplier: Thermo Scientific Chemicals

Baking powder, medicine (cathartic), component of Fehling's solution, silvering mirrors

Supplier: Thermo Scientific Chemicals

MDL: MFCD00148863

Supplier: Thermo Scientific Chemicals

MDL: MFCD00150989 Beilstein Registry No.: 6113568 Notes: Loses water of crystallization at 140°C unstable above 225°C

Supplier: Thermo Scientific Chemicals

Powder

Supplier: Genetex

The RNAs that direct protein synthesis in animals and plant cells are synthesized in the nucleus as large precursors (pre-mRNAs). The protein coding sequences in pre-mRNA molecules are arranged in discontinuous segments - exons interspersed with noncoding sequences - introns. In a process termed splicing, these introns are efficiently removed before the pre-mRNA is transported from the nucleus to the cytoplasm, where it is translated into protein. Studies have shown that nuclear pre-mRNA splicing takes place in a multi-component structure termed a spliceosome. The polypyrimidine tract-binding (PTB) protein-associated splicing factor (PSF), which plays an essential role in mammalian spliceosomes, is a ubiquitous nuclear matrix protein. A complex between PTB and PSF is necessary for pre-mRNA splicing. PSF contains two consensus RNA-binding domains and an unusual amino terminus rich in proline and glutamine residues. The RNA-binding properties of PSF are apparently identical to those of PTB. Both proteins, together and independently, bind the polypyrimidine tract of mammalian introns. However, the nuclear localization of PSF and PTB and their distribution in subnuclear fractions differ markedly: isolated nuclear matrices contain a bulk of PSF, but only minor amounts of PTB. In confocal microscopy both proteins appear in speckles, the majority of which do not co-localize. These PTB/PSF complexes, as well as the observed PSF-PTB interaction, may reflect the presence of PTB and PSF in spliceosomal complexes during RNA processing, although other data point to different cellular distribution and nuclear matrix association of the majority of PSF and PTB. The cleavage of PSF during lysis of immature myeloid cells is accompanied by digestion of the PTB splicing regulator but not other proteins tested. In contrast, during apoptosis PTB is degraded while PSF remains intact. Proteolytic degradation of PSF specifically occurs in intact myeloid cells and this process is enhanced upon immature myeloid cell lysis; PSF is completely cleaved to a 47 kDa proteolytic cleavage product (p47), due to potent proteolytic activity found in these cells but rare in other cells and tissues. Furthermore, p47 is abundant in intact normal and tumor myeloid cells while in other cell types it is undetectable. The bone marrow 47 kDa protein is a fragment constituting the N-terminal, protease-resistant half of the splicing factor PSF. PSF is highly basic and migrates anomalously on SDS gels. The 47 kDa protein of mouse cells of immature myeloid origin (bone marrow and acute myeloid leukemia) exhibits a gel migration pattern corresponding to a 49 kDa molecule. In other cell types such as lymphoid cells and in peripheral blood cells, PSF appears as approx. 100 kDa or 75 kDa molecules. The sequence of a fragment of mouse PSF was found to be remarkably similar to that of human PSF ( > 98% homology). Also, the sequences of PSF and the human (h) 100 kDa DNA-pairing protein (hPOMp100) reveals identity. Homologous pairing is a fundamental biological reaction implicated in various cellular processes such as DNA recombination and repair, chromosome pairing, sister chromatid cohesion and chromosome condensation, gene inactivation and initiation of replication. The base pairing is also involved in spliceosome assembly resulting in formation of a dynamic Holliday-like structure within which splicing occurs. Indeed, PSF/hPOMp100 bind both singlestranded (ss) and double-stranded (ds) DNA and facilitates the renaturation of complementary ssDNA molecules. Importantly, PSF/hPOMp100 promotes the formation of D-loops in superhelical duplex DNA. PSF/hPOMp100 also serves as an efficient substrate for protein kinase C (PKC) in vitro. PKC phosphorylation of PSF/hPOMp100 stimulates its DNA binding and D-loop formation activity suggesting a possible regulatory mechanism. PSF has been demonstrated to interact with a variety of cellular targets including the human pro-oncoproteins EWS, hPOMp75/TLS and calmodulin, the RNA/DNAbinding nuclear protein p54nrb/NonO (the homolog of PSF) and DNA topoisomerase. A direct interaction has been observed, between PSF and topoisomerase I which has been implied in DNA recombination, DNA repair, and chromosome formation and may act as a transcription factor and a protein kinase. PSF is also expressed by differentiating neurons in developing mouse brain. Both the expression of PSF mRNA in cortex and cerebellum and PSF immunoreactivity in all brain areas has been found to be high during embryonic and early postnatal life. In adult tissue, only various neuronal populations in the hippocampus and olfactory bulb express PSF. PSF is expressed by differentiating neurons but not by astrocytic cells including radial glia; however oligodendrocytes differentiating in vitro were found to express it. The restricted expression of PSF suggests that it is involved in the control of neuronal-specific splicing events occurring at particular stages of neuronal differentiation and maturation. Monoclonal antibodies reacting specifically with PSF are useful tools for the molecular identification and characterization of the functional activity of PSF.

Supplier: United Scientific Supplies

ELECTROSCOPE QUANTITATIVE

Supplier: United Scientific Supplies

ENERGY TRANSFORMATION BALLS PR2

Supplier: United Scientific Supplies

MAGNETIC FIELD DEMONSTRATOR 3D

Supplier: Thermo Fisher Scientific

VACUUM PUMP HAND OPPERATED W GAUGE

Supplier: Aladdin Scientific

General DescriptionCitric acid also called 2-hydroxy-propane-1,2,3-tricarboxylic acid, is a component of the tricarboxylic acid cycle in all organisms. Industrial production of citric acid use fungal, yeast and citrus fruit as the major source.

Supplier: Aladdin Scientific

General DescriptionCitric acid also called 2-hydroxy-propane-1,2,3-tricarboxylic acid, is a component of the tricarboxylic acid cycle in all organisms. Industrial production of citric acid use fungal, yeast and citrus fruit as the major source.

Supplier: Aladdin Scientific

Carboplatin is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of carboplatin was inspired from the efficacy of its progenitor, Cisplatin (sc-200896), the first of this class of antineoplastic agents.

Supplier: Aladdin Scientific

CA3 (CIL56) CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS). TargetsYAP/TEAD interactionin vitro CA3 strongly inhibits esophageal adenocarcinoma cell growthin vitro. CA3 can effectively suppress tumor cell proliferation, induce apoptosis, reduce tumor sphere formation, and the population of ALDH1+ cells.

Supplier: Aladdin Scientific

CA3 (CIL56) CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS). TargetsYAP/TEAD interactionin vitro CA3 strongly inhibits esophageal adenocarcinoma cell growthin vitro. CA3 can effectively suppress tumor cell proliferation, induce apoptosis, reduce tumor sphere formation, and the population of ALDH1+ cells.

Supplier: Aladdin Scientific

AZD8835 ia a novel mixed inhibitor ofPI3 KαandPI3 Kδwith IC50 of 6.2 nM and 5.7 nM, respectively, also with selectivity againstPI3 Kβ(IC50=431 nM) andPI3 Kγ(IC50=90 nM). TargetsPI3 Kδ (Cell-based assay); PI3 Kα (Cell-free assay); PI3 Kγ (Cell-based assay); PI3 Kβ (Cell-based assay) 5.7 nM; 6.2 nM; 90 nM; 431 nMIn vitroAZD8835 is a potent inhibitor of PI3 Kα (wild type, E545 K and H1047 R mutations) and PI3 Kδ with excellent selectivity vs. PI3 Kβ, PI3 Kγ and an excellent general kinase selectivity.

Supplier: Aladdin Scientific

AZD1390 is a first-in-class orally available and CNS penetrantATMinhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases.TargetsATM (Cell-based assay) 0.78 nM In vitro AZD1390 blocks ATM-dependent DDR (DNA damage response) pathway activity and combines with radiation to induce G2 cell cycle phase accumulation, micronuclei, and apoptosis. AZD1390 radiosensitizes glioma and lung cancer cell lines, with p53 mutant glioma cells generally being more radiosensitized than wild type. AZD1390 results in increased genome instability.In vivoAZD1390 displays excellent oral bioavailability in preclinical species (66% in rat and 74% in dog).

Supplier: Aladdin Scientific

AZD1390 is a first-in-class orally available and CNS penetrantATMinhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases.TargetsATM (Cell-based assay) 0.78 nM In vitro AZD1390 blocks ATM-dependent DDR (DNA damage response) pathway activity and combines with radiation to induce G2 cell cycle phase accumulation, micronuclei, and apoptosis. AZD1390 radiosensitizes glioma and lung cancer cell lines, with p53 mutant glioma cells generally being more radiosensitized than wild type. AZD1390 results in increased genome instability.In vivoAZD1390 displays excellent oral bioavailability in preclinical species (66% in rat and 74% in dog).